Abdominal perineal resection or wilde local excision in primary anorectal malignant melanoma. Case report and review

Latteri, Saverio; Teodoro, Michele; Malaguarnera, Michele; Mannino, Maurizio; Currò, Giuseppe; G, La Greca

doi:10.1016/j.amsu.2017.03.039

Cited by 21 publications

(28 citation statements)

References 23 publications

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“…The name is derived from the protein solubility characteristic: 100% in saturated ammonium sulphate at neutral pH. S-100B is a dimer, consists of two isomers a and b; all possible combination can occur (S-1001a, S-100 ab, and S-100bb) [ 60 , 61 ].…”

Section: Introductionmentioning

confidence: 99%

Anorectal mucosal melanoma

et al. 2018

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Anorectal melanoma is an uncommon and aggressive mucosal melanocytic malignancy. Due to its rarity, the pre-operative diagnosis remains difficult. The first symptoms are non-specific such as anal bleeding, anal mass or pain. Although anorectal melanoma carries a poor prognosis; optimal therapeutics strategies are unclear.Surgical resection remains the mainstay of treatment. The optimal surgical procedure for primary tumours is controversial and can vary from wide local excision or endoscopic mucosal resection (EMR) to an abdomino-perineal resection.A high degree of uncertainly exists regarding the benefit of radiation therapy or chemotherapy. The treatment of advanced melanoma is evolving rapidly with better understanding of the disease biology and immunology. Considerable effort has been devoted to the identification of molecular determinants of response to target therapies and immunotherapy.

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Section: Introductionmentioning

confidence: 99%

Anorectal mucosal melanoma

et al. 2018

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“…The prognosis of anorectal malignant melanoma is very poor due to its aggressive characteristics. Adjuvant therapies such as radiotherapy, chemotherapy and targeted therapies are administered in a number of cases, but due to rarity of the disease, randomized controlled trials have not been conducted to evaluate the additional benefit of these treatment mobilities [ 9 ]. In our case, because of the elderly patient, adjuvant therapy was not introduced.…”

Section: Discussionmentioning

confidence: 99%

Combined laparoscopic abdomino-endoscopic perineal total mesorectal excision for anorectal malignant melanoma: A case report

Ohta

Inoue

Goto

et al. 2018

International Journal of Surgery Case Reports

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HighlightsThis is the first report of combined laparoscopic abdomino-endoscopic perineal total mesorectal excision for anorectal malignant melanoma.This procedure provides not only better exposure of the extralevator surgical field, but also safety resection margins compared with the conventional abdominoperineal resection.Our experience showed safety and feasible option for anorectal malignant diseases.

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“…Anorectal malignant melanoma (ARMM), a fatal malignancy with high malignant degree and poor patient prognosis, has shown increasing incidence rate in recent years (1,2). Since the clinical symptoms of ARMM patients are inapparent and non-specific, generally manifested as constipation, hematochezia, diarrhea, proctalgia and pruritus, most patients tend to be at the middle or advanced stage at diagnosis.…”

Section: Introductionmentioning

confidence: 99%

Efficacy and prognosis of surgical treatment in ARMM and its effects on immune and inflammatory profiles

2020

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The aim of the present study was to investigate the efficacy and prognosis of surgical treatment in anorectal malignant melanoma (ARMM) as well as its effects on immune and inflammatory profiles. A total of 64 patients with ARMM were enrolled and divided into control group (n=32) and observation group (n=32) based on different therapeutic methods. Patients in the observation group underwent wide local excision, while those in the control group were given non-surgical treatment. The immune function was compared between the two groups after treatment. The expression levels of serum IL-17, IL-23 and vascular endothelial growth factor (VEGF) were compared between the groups before and after treatment. Patients were followed up for 5 years to observe the recurrence and survival rates in the two groups. Compared with those in the control group, the levels of cluster of differentiation (CD)3 + , CD4 + and CD4 + /CD8 + were increased, while the level of CD8 + was reduced in the observation group (P<0.05). The levels of serum IL-17, IL-23 and VEGF were significantly lower in both groups at 4, 6 and 8 weeks after treatment than those before treatment, and the decrease was more obvious in the observation group (P<0.05). The observation group exhibited a notably elevated 5-year survival rate and a remarkably decreased recurrence rate in comparison with the control group (P<0.05). For ARMM, surgical treatment is more effective than non-surgical treatment, which has less effect on immune function, is able to reduce serum IL-17, IL-23 and VEGF levels, lower recurrence rate, improve patient survival rate, and plays a certain positive role in prolonging the survival time of ARMM patients.

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Abdominal perineal resection or wilde local excision in primary anorectal malignant melanoma. Case report and review

Cited by 21 publications

References 23 publications

Anorectal mucosal melanoma

Anorectal mucosal melanoma

Combined laparoscopic abdomino-endoscopic perineal total mesorectal excision for anorectal malignant melanoma: A case report

Efficacy and prognosis of surgical treatment in ARMM and its effects on immune and inflammatory profiles

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