Aberrant LncRNA Expression Profile in a Contusion Spinal Cord Injury Mouse Model

Ding, Yunchuan; Song, Zhiwen; Wang, Zhibin

doi:10.1155/2016/9249401

Cited by 38 publications

(30 citation statements)

References 41 publications

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“…Noncoding RNAs such as circulating microRNAs have been found out to be markedly increased in the serum relative to the severity of ASCI, which may be promising biomarkers for diagnose and predicting the severity of ASCI [22]. By using a microarray method in a contusion SCI mouse model, a dynamic lncRNA-mRNA network containing 264 lncRNAs and 949 mRNAs has been constructed to illuminate the interactions between the lncRNAs and mRNAs [23], verifying the differential expression of lncRNAs in contusion SCI. In this study, lncRNA DGCR5 was found to be down-regulated in ASCI.…”

Section: Discussionmentioning

confidence: 99%

LncRNA DGCR5 suppresses neuronal apoptosis to improve acute spinal cord injury through targeting PRDM5

Zhang

Wang

et al. 2018

Cell Cycle

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Spinal cord injury (SCI) usually results in neurological damage. DGCR5 is closely related to neurological disorders, and this study aims to explore its role in neuronal apoptosis in acute SCI. The ASCI model was established in rats, and the Basso, Beattie, and Bresnahan (BBB) scoring was used to assess the neurological function. The expression of RNA and protein was quantified by quantitative real-time PCR (qRT-PCR) and western blotting, respectively. The oxygenglucose deprivation (OGD) was performed upon neurons and apoptosis was evaluated by flow cytometry. The interaction and binding between DGCR5 and PRDM5 was detected with RNA pull-down and RIP assay, respectively. DGCR5 was down-regulated in ASCI model rat and in neurons treated with hypoxia. Over-expression of DGCR5 inhibited neuronal apoptosis. Interaction between DGCR5 negatively regulated PRDM5 protein expression by binding and interacting with it. DGCR5 inhibited neuronal apoptosis through PRDM5. Over-expressed DGCR5 ameliorated ASCI in rat. DGCR5 suppresses neuronal apoptosis through directly binding and negatively regulating PRDM5, and thereby ameliorating ASCI.

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Section: Discussionmentioning

confidence: 99%

LncRNA DGCR5 suppresses neuronal apoptosis to improve acute spinal cord injury through targeting PRDM5

Zhang

Wang

et al. 2018

Cell Cycle

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“…These results suggested that lncRNA expression was highly dynamic across different stages. Nonetheless, these studies have aimed to reveal the lncRNA profiles in different post‐injury time‐points, from immediate, acute, subchronic to chronic phases after SCI (Figure ). These studies provided preliminary views on stage‐specific lncRNA modulation.…”

Section: Lncrna Expression Profiling In Scimentioning

confidence: 99%

Long non‐coding RNAs in the spinal cord injury: Novel spotlight

et al. 2019

J Cellular Molecular Medi

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Spinal cord injury (SCI) may lead to persistent locomotor dysfunction and somatosensory disorders, which adversely affect the quality of life of patients and cause a significant economic burden to the society. The efficacies of current therapeutic interventions are still far from satisfaction as the secondary damages resulting from the complex and progressive molecular alterations after SCI are not properly addressed. Recent studies revealed that long non‐coding RNAs (lncRNAs) are abundant in the brain and might play critical roles in several nervous system disorders. At the cellular level, lncRNAs have been shown to regulate the expression of protein‐coding RNAs and hence participate in neuronal death, demyelination and glia activation. Notably, SCI is characterized by these biological processes, suggesting that lncRNAs could be novel modulators in the pathogenesis of SCI. This review describes recent progresses in the lncRNA transcriptome analyses and their molecular functions in regulating SCI progression.

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“…1). For example, Ding et al [21] found that few changes in lncRNA expression levels were noted 1 day after injury, and significant differential changes in lncRNA expression peaked 1 week after SCI and subsequently declined until 3 weeks after injury. In another study, Zhou et al [22] used microarray analysis and found that 772 lncRNAs were identified as changed in a rat model for 2 h after SCI.…”

Section: Scimentioning

confidence: 99%

Functional roles of lncRNAs and its potential mechanisms in neuropathic pain

Tang¹,

Zhou²,

Jing³

et al. 2019

Clin Epigenet

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Neuropathic pain (NP) is ranked as one of the major forms of chronic pain and emerges as a direct consequence of a lesion or disease affecting the somatosensory nervous system. Despite great advances into the mechanisms of NP, clinical practice is still not satisfactory. Fortunately, progress in elucidating unique features and multiple molecular mechanisms of long non-coding RNAs (lncRNAs) in NP has emerged in the past 10 years, suggesting that novel therapeutic strategies for pain treatment may be proposed. In this review, we will concentrate on recent studies associated with lncRNAs in NP. First, we will describe the alterations of lncRNA expression after spinal cord injury (SCI) and peripheral nerve injury (PNI), and then we illustrate the role of some specific lncRNAs in detail, which may offer new insights into our understanding of the etiology and pathophysiology of NP. Finally, we put special emphasis on the altered expression of lncRNAs in the diverse biological process of NP. Recent advances we summarized above in the development of NP may facilitate translation of these findings from bench to bedside in the future.

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Aberrant LncRNA Expression Profile in a Contusion Spinal Cord Injury Mouse Model

Cited by 38 publications

References 41 publications

LncRNA DGCR5 suppresses neuronal apoptosis to improve acute spinal cord injury through targeting PRDM5

LncRNA DGCR5 suppresses neuronal apoptosis to improve acute spinal cord injury through targeting PRDM5

Long non‐coding RNAs in the spinal cord injury: Novel spotlight

Functional roles of lncRNAs and its potential mechanisms in neuropathic pain

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