Aberrant Secretion of Salivary A, B, and H Group Substances in Human Beings

McNeil, Crichton; Trentelman, Elmer F.; Kreutzer, Virginia; Fullmer, Cyril D.

doi:10.1093/ajcp/28.2.145

Cited by 41 publications

(17 citation statements)

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“…A further complication to the problem is the occurrence of people with saliva containing low A substance levels although the red cells have a normal Aj status [1,2,15]. Bhatia and Randeria [1], in a recent study, found one example with a low A :H substance ratio in a study of 50 Aj secretor salivas.…”

Section: Discussionmentioning

confidence: 99%

“…Bhatia and Randeria [1], in a recent study, found one example with a low A :H substance ratio in a study of 50 Aj secretor salivas. They reviewed the genetic theories [2,15] postulated to explain the occurrence of aberrant secretors, but concluded that the genetics was still not understood. It would appear that the A expression of the secretor genes [21] can be reduced by suppressor genes that have little effect on H expression and no or little effect on normal A development on the red cells.…”

Section: Discussionmentioning

confidence: 99%

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Observations on a New Example of the A(m) Phenotype which Demonstrates Reduced A Secretion

Darnborough¹,

Voak²,

Pepper³

1973

Vox Sanguinis

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A new example of the A(m) phenotype is described. The red cells have a very weak A status, best demonstrated by ‘immune’ anti-A sera using enzyme techniques. The serum contains normal anti-B but no anti-A or A substance. The saliva contains A, H and Le^a substances, but the A:H substance ratio was lower than normal, indicating that the y y genes reduce the formation of secreted A as well as that of cellular A substance.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Observations on a New Example of the A(m) Phenotype which Demonstrates Reduced A Secretion

Darnborough¹,

Voak²,

Pepper³

1973

Vox Sanguinis

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“…Investigation of the patient's saliva reveals that she belongs to the socalled aberrant secretors [4]. She secretes no H substance.…”

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confidence: 99%

Anti-A(1) Le^b in Serum of a Person of a Blood Group A(1)h

Gundolf¹

1973

Vox Sanguinis

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An antibody, anti-A(1), Le^b, has been found in the serum of a person belonging to group A(1)h, with complete depression of H on the red cells as well as in the saliva. It differs from earlier examples of the antibody in that it can be neutralized by A(1), nL, secretor saliva as well as O Le^b secretor saliva in addition to A(1) Le^b secretor saliva. Although the proposita secretes A substance, she only secretes Lea substance and not Leb substance. No such abnormalities were found in the family investigated. An interpretation of the case is given according to the classical hypothesis of ABO and Lewis system development.

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“…Some exceptions to this generality were reported by McNeil et al [8] who, by using Lotus tetragonolobus as an anti-H source, encountered some secretors whose saliva inhibited either the anti-A or the anti-B but not the anti-H. These cases they labelled as "aberrant secretors ".…”

mentioning

confidence: 94%