Abnormal amygdala connectivity in patients with primary insomnia: Evidence from resting state fMRI

Huang, Zhaoyang; Liang, Peipeng; Jia, Xiuqin; Zhan, Shuqin; Li, Ning; Ding, Yan; Lu, Jie; Wang, Yuping; Li, Kuncheng

doi:10.1016/j.ejrad.2011.03.029

Cited by 167 publications

(174 citation statements)

References 19 publications

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“…This abnormal pattern of insula coactivation may indicate that interoceptive awareness of bodily states, one of the established roles of the insula [60,61], is impaired in patients with insomnia. However, the lack of simultaneous EEG recordings to ensure defined states of sleep or wakefulness [56][57][58]62], coupled with application of liberal statistical thresholds, may partially explain variability in findings across resting-state fMRI studies in insomnia.…”

Section: Functional Neuroimagingmentioning

confidence: 96%

Neuroimaging Insights into Insomnia

Spiegelhalder

Regen

Baglioni

et al. 2015

Curr Neurol Neurosci Rep

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Insomnia is one of the most prevalent health complaints afflicting approximately 10% of the population in Western industrialized countries at a clinical level. Despite the proposition that both biological and psychological factors play a role in the experience of insomnia, the field continues to puzzle over so-called "discrepancies" between objective and subjective measurements of sleep and daytime functioning. The promise of neuroimaging is to uncover physiological processes that may readily explain patient reports. However, while there has been an explosion in the number of studies investigating the neural correlates of insomnia with neuroimaging technologies, there appears to be little consistency in findings across studies. We suggest a number of methodological reasons which may, at least partially, explain variability in findings across neuroimaging studies in insomnia.

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Section: Functional Neuroimagingmentioning

confidence: 96%

Neuroimaging Insights into Insomnia

Spiegelhalder

Regen

Baglioni

et al. 2015

Curr Neurol Neurosci Rep

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show abstract

“…[29][30][31][32] A literature review identified 3 restingstate fMRI studies in patients with insomnia that investigated functional connectivity in salience, emotional and memory networks. 16,33,34 However, none of these studies focused on betweengroup dif ferences in the DMN or investigated the association between DMN connectivity and objective sleep parameters.…”

Section: J Psychiatry Neurosci 2016;41(5)mentioning

confidence: 99%

Objective sleep disturbances are associated with greater waking resting-state connectivity between the retrosplenial cortex/hippocampus and various nodes of the default mode network

Regen

Kyle

Nissen

et al. 2016

jpn

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“…4 Killgore et al found increased functional connectivity between the primary visual cortex and other sensory regions such as the primary auditory cortex, olfactory cortex, and supplementary motor cortex in PCPIs compared with GSs. 11 Our previous study found significant decreased functional connectivity within the default mode network subregions using seed-based region-to-region functional connectivity method.…”

Section: Introductionmentioning

confidence: 99%

“…[1][2][3] Occasional episodes of insomnia symptoms are reported in half of all adults, while chronic insomnia is prevalent in 10-15% of the adult population. 4 In spite of a recent increase in neuroimaging research into PCPIs, it has not gleaned a consistent conclusion about its neuropathology after reviewing the neuroimaging studies of primary insomnia, especially with regard to the structural studies of brain alterations. 5 The results of structural studies are either contradictory or required replication.…”

Section: Introductionmentioning

confidence: 99%

Gender Differences in Regional Brain Activity in Patients with Chronic Primary Insomnia: Evidence from a Resting-State fMRI Study

Dai

Nie

Liu

et al. 2016

Journal of Clinical Sleep Medicine

115

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Study Objectives: To explore the regional brain activities in patients with chronic primary insomnia (PCPIs) and their sex differences. Methods: Forty-two PCPIs (27 females, 15 males) and 42 good sleepers (GSs; 24 females, 18 males) were recruited. Six PCPIs (3 males, 3 females) were scanned twice by MRI to examine the test-retest reliability. Amplitude of low frequency fluctuation (ALFF) method was used to assess the local brain features. The mean signal values of the different ALFF areas were analyzed with a receiver operating characteristic (ROC) curve. Simple linear regression analysis was performed to investigate the relationships between clinical features and different brain areas. Results: Both female and male PCPIs showed higher ALFF in the temporal lobe and occipital lobe, especially in female PCPIs. Female PCPIs had lower ALFF in the bilateral cerebellum posterior lobe, left dorsolateral prefrontal cortex, and bilateral limbic lobe; however, male PCPIs showed lower ALFF in the left occipital gyrus. The mean signal value of the cerebellum in female PCPIs showed negative correlations with negative emotions. Compared with male PCPIs, female PCPIs showed higher ALFF in the bilateral middle temporal gyrus and lower ALFF in the left limbic lobe. The different areas showed high testretest stability (Clusters of contiguous volumes ≥ 1080 mm 3 with an intraclass correlation coefficient ≥ 0.80) and high degree of sensitivity and specificity. Conclusions: Female PCPIs showed more regional brain differences with higher and lower ALFF responses than male PCPIs. However, they shared analogous excessive hyperarousal mechanism and wide variations in aberrant brain areas. I NTRO DUCTI O NPatients with chronic primary insomnia (PCPIs), who underwent the subjective experience of chronically disturbed sleep, sleep loss, non-refreshing sleep, and heightened arousal in bed with impaired quality of life, showed a decreased ability to disengage from external information processing at sleep onset.1-3 Occasional episodes of insomnia symptoms are reported in half of all adults, while chronic insomnia is prevalent in 10-15% of the adult population. 4 In spite of a recent increase in neuroimaging research into PCPIs, it has not gleaned a consistent conclusion about its neuropathology after reviewing the neuroimaging studies of primary insomnia, especially with regard to the structural studies of brain alterations. 5 The results of structural studies are either contradictory or required replication. Altena et al. found that PCPIs had a smaller volume of reduced gray matter in the precuneus and left orbitofrontal cortex which strongly correlated with the subjective severity of insomnia, but increased gray matter volume was not found. 6 Joo et al. demonstrated significantly reduced gray matter concentrations in the dorsolateral prefrontal and pericentral cortices, superior temporal gyrus, and cerebellum, and decreased gray matter volumes in the medial frontal lobe and middle temporal lobe in PCPIs compared with good sleepers (GSs), ...

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Abnormal amygdala connectivity in patients with primary insomnia: Evidence from resting state fMRI

Cited by 167 publications

References 19 publications

Neuroimaging Insights into Insomnia

Neuroimaging Insights into Insomnia

Objective sleep disturbances are associated with greater waking resting-state connectivity between the retrosplenial cortex/hippocampus and various nodes of the default mode network

Gender Differences in Regional Brain Activity in Patients with Chronic Primary Insomnia: Evidence from a Resting-State fMRI Study

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