Abnormal brain scans in multiple sclerosis.

Cohan, Stanley; Fermaglich, Joseph; Auth, Thomas L.

doi:10.1136/jnnp.38.2.120

Cited by 14 publications

(4 citation statements)

References 11 publications

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“…Although the retina developmentally is an extension of the cerebrum, MS plaque formation is not possible in the retina due to the lack of myelin. Technetium brain scans are usually normal in MS patients, but a transitory breakdown of the BBB has been found in MS patients during acute attack or exacerbation (11,12,13,14). This observation was utilized in the present study in which marginal accumulation of the nuclide was looked for in order to demonstrate minor disease fluctuations.…”

mentioning

confidence: 99%

Multiple sclerosis: periphlebitis retinalis et cerebro-spinalis A correlation between periphlebitis retinalis and abnormal technetium brain scintigraphy

Engell

Hvidberg

Uhrenholdt

1984

Acta Neurologica Scandinavica

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Periphlebitis retinae (PR) in multiple sclerosis (MS) is seen as transitory infiltrations around veins in the otherwise normal retina. Cellular infiltrations have been found around veins in the central nervous system (CNS), where it has been suggested that they are the first event in plaque formation. Technetium brain scans are usually normal in MS patients, but transitory abnormal scans of the cerebrum have been found in MS patients during acute attack or exacerbation. In order to test the hypothesis that active PR is a sign of simultaneous disease activity in the CNS, 29 technetium brain scans were carried out on 14 MS patients with active PR and on 15 MS patients without any signs of PR. Significantly more of the patients with active PR, compared with MS patients with previous PR, displayed abnormal brain scans. This indicates that a disruption of the blood brain barrier (BBB) and active PR occur simultaneously in MS.

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mentioning

confidence: 99%

Multiple sclerosis: periphlebitis retinalis et cerebro-spinalis A correlation between periphlebitis retinalis and abnormal technetium brain scintigraphy

Engell

Hvidberg

Uhrenholdt

1984

Acta Neurologica Scandinavica

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“…Cohan et a1 [ 5 ] showed a sizable right parietal lesion on a radionuclide scan that could not be explained on the basis of symptoms or clinical signs.…”

Section: Discussionmentioning

confidence: 97%

Computerized tomography in the diagnostic evaluation of multiple sclerosis

Hershey¹,

Gado²,

Trotter³

1979

Annals of Neurology

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Sixty-six patients with a tentative or certain diagnosis of multiple sclerosis (MS) were examined with cranial computerized tomography (CT). Abnormalities found in 19 (29%) included discrete areas of decreased white matter density, enlarged ventricles, cortical atrophy, and focal areas of contrast enhancement. The presence of white matter lucencies and ventricular dilatation correlated with an increased incidence of diffuse hyperreflexia and mental impairment. Since half the patients with contrast-enhancing lesions were clinically stable, their lesions may represent acute asymptomatic plaques. Abnormalities on CT scan were observed more often in older patients whose disease had lasted longer and was clinically more definite. Since findings were sparse in early, less definite disease, the use of CT as a purely diagnostic tool is limited.

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“…In 1960, Prockop and Heinz [6] documented biopsy-proved MS which showed angiegraphic signs of mass lesion. Isotope brain scans sometimes reveal positive findings in MS, perhaps during a transient breakdown in the blood-brain barrier [7].…”

Section: Discussionmentioning

confidence: 99%