Abnormal content of n−6 and n−3 long-chain unsaturated fatty acids in the phosphoglycerides and cholesterol esters of parahippocampal cortex from Alzheimer's disease patients and its relationship to acetyl CoA content

Corrigan, Frank M.; Horrobin, D.F.; Skinner, E. R.; Besson, J. A. O.; Cooper, Marie

doi:10.1016/s1357-2725(97)00125-8

Cited by 112 publications

(45 citation statements)

References 35 publications

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“…It has long been suggested that AD is associated with brain lipid defects [165][166][167][168][169][170]. More recently, epidemiological studies [171][172][173][174][175][176][177] have suggested that high fish and/or omega-3 fatty acid consumption is inversely associated with cognitive impairment, cognitive decline, and/or development of dementia or AD.…”

Section: Alzheimer's Disease and Dementiamentioning

confidence: 99%

Omega-3 fatty acids and neuropsychiatric disorders

2005

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-Epidemiological evidence suggests that dietary consumption of the long chain omega-3 fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), commonly found in fish or fish oil, may modify the risk for certain neuropsychiatric disorders. As evidence, decreased blood levels of omega-3 fatty acids have been associated with several neuropsychiatric conditions, including Attention Deficit (Hyperactivity) Disorder, Alzheimer's Disease, Schizophrenia and Depression. Supplementation studies, using individual or combination omega-3 fatty acids, suggest the possibility for decreased symptoms associated with some of these conditions. Thus far, however, the benefits of supplementation, in terms of decreasing disease risk and/or aiding in symptom management, are not clear and more research is needed. The reasons for blood fatty acid alterations in these disorders are not known, nor are the potential mechanisms by which omega-3 fatty acids may function in normal neuronal activity and neuropsychiatric disease prevention and/or treatment. It is clear, however, that DHA is the predominant n-3 fatty acid found in the brain and that EPA plays an important role as an anti-inflammatory precursor. Both DHA and EPA can be linked with many aspects of neural function, including neurotransmission, membrane fluidity, ion channel and enzyme regulation and gene expression. This review summarizes the knowledge in terms of dietary omega-3 fatty acid intake and metabolism, as well as evidence pointing to potential mechanisms of omega-3 fatty acids in normal brain functioning, development of neuropsychiatric disorders and efficacy of omega-3 fatty acid supplementation in terms of symptom management.

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Section: Alzheimer's Disease and Dementiamentioning

confidence: 99%

Omega-3 fatty acids and neuropsychiatric disorders

2005

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“…When low DHA was observed, it was not specific for DHA: either AA and/or adrenic acid were also decreased [16,18,21], or the lower DHA was a function of a decrease in one of the lipid classes, most commonly plasmalogen PE [20]. Increases of up to 50% for DHA [17,19,20] and 4 fold for adrenic acid [17] have also been reported for some regions of AD brain.…”

Section: Brain Levels Of Dha In Alzheimer's Diseasementioning

confidence: 99%

“…Amongst the polyunsaturates, there were no differences due to AD except for 3-4 fold higher levels of adrenic acid in grey matter, as well as higher DHA in parietal white matter. In 1998, Corrigan et al [18] reported the fatty acid composition of parahippocampal cortex in 8 AD patients and 6 age-matched controls. AD was confirmed histologically in each case.…”

Section: Brain Levels Of Dha In Alzheimer's Diseasementioning

confidence: 99%

Linking low docosahexaenoic acid intake to Alzheimer’s disease: caution recommended

Cunnane

Plourde

Vandal

et al. 2007

OCL

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“…PGE 3 ) and 5-series LT (e.g. LTB 5 ). It is hypothesized that elevation of DGLA and/or EPA in body phospholipid (PL) will be at the expense of the sometimes disease-promoting 2-series PG (e.g.…”

Section: Introductionmentioning

confidence: 99%

Potential of Evening Primrose, Borage, Black Currant, and Fungal Oils in Human Health

Barre¹

2001

Ann Nutr Metab

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Abnormal content of n−6 and n−3 long-chain unsaturated fatty acids in the phosphoglycerides and cholesterol esters of parahippocampal cortex from Alzheimer's disease patients and its relationship to acetyl CoA content

Cited by 112 publications

References 35 publications

Omega-3 fatty acids and neuropsychiatric disorders

Omega-3 fatty acids and neuropsychiatric disorders

Linking low docosahexaenoic acid intake to Alzheimer’s disease: caution recommended

Potential of Evening Primrose, Borage, Black Currant, and Fungal Oils in Human Health

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