Abnormal Methylation of Imprinted Genes and Cigarette Smoking: Assessment of Their Association With the Risk of Male Infertility

Dong, Huijuan; Wang, Youxin; Zou, Zhikang; Chen, Limin; Shen, Chuan-Yun; Xu, Shaoqiang; Zhang, Jie; Zhao, Fei; Ge, Siqi; Gao, Qing; Hu, Haixiang; Song, Manshu; Wang, Wei

doi:10.1177/1933719116650755

Cited by 50 publications

(32 citation statements)

References 55 publications

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“…The authors of this study also identified that smoking is associated with changes in sperm DNA methylation patterns, specifically at CpGs located in regions related to MAPK8IP and TKR genes. A link between smoking, male fertility and methylation at imprinted loci has been highlighted in a study by Dong et al (2016). In this study, they revealed that hypomethylation of the H19 imprint control region (ICR) and hypermethylation of the SNRPN-ICR were associated with infertility and that the risk was potentiated by smoking.…”

Section: Dna Methylationmentioning

confidence: 83%

“…Given that sperm are one of the most diverse cell types (Ramon et al 2014) and that sperm have been reported to be epigenetically heterogeneous (Laurentino et al 2016), future investigations using highthroughput single cell epigenomics will be important to help determine whether aberrant infertility-related epigenetic marks are present in all spermatozoa of the ejaculate. Finally, advising couples suffering from UMI, and males in general, on known risk factors such as smoking (Dong et al 2016, Laqqan et al 2017b, obesity (Katib 2015, Craig et al 2017 and alcohol consumption (Ouko et al 2009, Lim & Song 2012 may help to reduce infertility-related epigenetic aberrancies in sperm and go some way on the long road to understanding and potentially treating male factor infertility.…”

Section: Discussionmentioning

confidence: 99%

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Epigenetic reprogramming during spermatogenesis and male factor infertility

McSwiggin¹,

O’Doherty²

2018

Reproduction

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Infertility is an often devastating diagnosis encountered by around one in six couples who are trying to conceive. Moving away from the long-held belief that infertility is primarily a female issue, it is now recognised that half, if not more, of these cases may be due to male factors. Recent evidence has suggested that epigenetic abnormalities in chromatin dynamics, DNA methylation or sperm-borne RNAs may contribute to male infertility. In light of advances in deep sequencing technologies, researchers have been able to increase the coverage and depth of sequencing results, which in turn has allowed more comprehensive analyses of spermatozoa chromatin dynamics and methylomes and enabled the discovery of new subsets of sperm RNAs. This review examines the most current literature related to epigenetic processes in the male germline and the associations of aberrant modifications with fertility and development.

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Section: Dna Methylationmentioning

confidence: 83%

Section: Discussionmentioning

confidence: 99%

Epigenetic reprogramming during spermatogenesis and male factor infertility

McSwiggin¹,

O’Doherty²

2018

Reproduction

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“…These changes in sperm histone acetylation entail similar changes in early embryos; thus, epigenetic alterations might be paternally transmitted, via SPZ, probably through changes in expression of histone acetyltransferases [ 205 ]. Chronic smoking exposure induces in sperm an elevated histone-to-protamine ratio [ 206 ], increased global acetylation of H4K8 and H4K12 [ 207 ] and abnormal methylation of imprinted genes [ 208 ]. As described in testis, Sirt1 seems to mediate most of BPA effects on male reproductive tracts [ 209 ].…”

Section: Epigenetic Mechanisms Are Sensitive To Environment and LImentioning

confidence: 99%

Environmental Impact on Male (In)Fertility via Epigenetic Route

Cescon

Chianese

Tavares

2020

JCM

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In the last 40 years, male reproductive health—which is very sensitive to both environmental exposure and metabolic status—has deteriorated and the poor sperm quality observed has been suggested to affect offspring development and its health in adult life. In this scenario, evidence now suggests that epigenetics shapes endocrine functions, linking genetics and environment. During fertilization, spermatozoa share with the oocyte their epigenome, along with their haploid genome, in order to orchestrate embryo development. The epigenetic signature of spermatozoa is the result of a dynamic modulation of the epigenetic marks occurring, firstly, in the testis—during germ cell progression—then, along the epididymis, where spermatozoa still receive molecules, conveyed by epididymosomes. Paternal lifestyle, including nutrition and exposure to hazardous substances, alters the phenotype of the next generations, through the remodeling of a sperm epigenetic blueprint that dynamically reacts to a wide range of environmental and lifestyle stressors. With that in mind, this review will summarize and discuss insights into germline epigenetic plasticity caused by environmental stimuli and diet and how spermatozoa may be carriers of induced epimutations across generations through a mechanism known as paternal transgenerational epigenetic inheritance.

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“…Epigenetic aberrations in imprinted genes have been associated with adverse effects on cancer [194], embryogenesis, nervous system development, and DNA repair [172,195]. Subfertile males harbored dysregulated sperm methylation profiles associated with abnormal sperm parameters [196]; specifically, hypomethylation of H19 and hypermethylation of SNRPN imprint control regions [196,197,198,199], which is exacerbated further by cigarette smoking [200]. Therefore, exposure to reproductive environmental toxins during critical windows of mammalian development can trigger irreversible and heritable epigenetic tags.…”

Section: Epigenetic Implicationsmentioning

confidence: 99%

Updates on the Effect of Mycotoxins on Male Reproductive Efficiency in Mammals

Khoury

Fayjaloun

Nassar

et al. 2019

Toxins

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Mycotoxins are ubiquitous and unavoidable harmful fungal products with the ability to cause disease in both animals and humans, and are found in almost all types of foods, with a greater prevalence in hot humid environments. These mycotoxins vary greatly in structure and biochemical effects; therefore, by better understanding the toxicological and pathological aspects of mycotoxins, we can be better equipped to fight the diseases, as well as the biological and economic devastations, they induce. Multiple studies point to the association between a recent increase in male infertility and the increased occurrence of these mycotoxins in the environment. Furthermore, understanding how mycotoxins may induce an accumulation of epimutations during parental lifetimes can shed light on their implications with respect to fertility and reproductive efficiency. By acknowledging the diversity of mycotoxin molecular function and mode of action, this review aims to address the current limited knowledge on the effects of these chemicals on spermatogenesis and the various endocrine and epigenetics patterns associated with their disruptions.

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Abnormal Methylation of Imprinted Genes and Cigarette Smoking: Assessment of Their Association With the Risk of Male Infertility

Cited by 50 publications

References 55 publications

Epigenetic reprogramming during spermatogenesis and male factor infertility

Epigenetic reprogramming during spermatogenesis and male factor infertility

Environmental Impact on Male (In)Fertility via Epigenetic Route

Updates on the Effect of Mycotoxins on Male Reproductive Efficiency in Mammals

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