AbobotulinumtoxinA Efficacy and Safety in Children With Equinus Foot Previously Treated With Botulinum Toxin

Dabrowski, Edward; Bonikowski, Marcin; Gormley, Mark E.; Volteau, Magali; Picaut, Philippe; Delgado, Mauricio R.

doi:10.1016/j.pediatrneurol.2017.12.013

Cited by 6 publications

(3 citation statements)

References 11 publications

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“…M. R. Delgado advanced our understanding of CP and associated treatment approaches through a series of impactful studies [ 71 , 72 ]. Initially focusing on lower limb spasticity, his research team first established the efficacy of AbobotulinumtoxinA in treating localized spasticity in 2010, with subsequent studies in 2016 and 2018 confirming its effectiveness and safety for conditions such as dynamic equinus foot deformity [ 65 , 73 , 74 ]. These studies highlighted improvements in muscle tone, gait, and functional goals, and demonstrated the sustained benefits of BoNT-A across multiple treatment cycles.…”

Section: Discussionmentioning

confidence: 99%

The Role of Botulinum Toxin Type-A in Spasticity: Research Trends from a Bibliometric Analysis

Facciorusso,

Spina,

Picelli

et al. 2024

Toxins

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Botulinum toxin type-A (BoNT-A) has emerged as a key therapeutic agent for the management of spasticity. This paper presents a comprehensive bibliometric and visual analysis of research concerning BoNT-A treatment of spasticity to elucidate current trends and future directions in this research area. A search was conducted in the Web of Science database for articles focused on the use of BoNT-A in spasticity published between 2000 and 2022. We extracted various metrics, including counts of publications and contributions from different countries, institutions, authors, and journals. Analytical methods in CiteSpace were employed for the examination of co-citations, collaborations, and the co-occurrence of keywords. Our search yielded 1489 publications. Analysis revealed a consistent annual increase in research output. The United States, United Kingdom, and Italy were the leading contributors. The top institution in this research was Assistance Publique Hopitaux, Paris. The journal containing the highest number of relevant publications was Toxins. Key frequently occurring keywords were ‘stroke’, ‘cerebral palsy’, ‘adult spasticity’, and ‘upper extremity’. This study identified 12 clusters of keywords and 15 clusters of co-cited references, indicating the main focus areas and emerging themes in this field. This study comprehensively analyzed and summarized trends in BoNT-A research in the field of spasticity over the past 22 years.

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Section: Discussionmentioning

confidence: 99%

The Role of Botulinum Toxin Type-A in Spasticity: Research Trends from a Bibliometric Analysis

Facciorusso,

Spina,

Picelli

et al. 2024

Toxins

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“…This phenomenon translates into BoNTs being an effective treatment for a variety of movement disorders and other neurological and non-neurological conditions. Several studies have indicated its effectiveness in the treatment of disorders such as dystonia, post stroke spasticity, and cerebral palsy to name a few [ 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 ]. The side effect profile of long-term botulinum toxin injections has been well documented, especially in individuals with dystonia and spasticity [ 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 ].…”

Section: Introductionmentioning

confidence: 99%

“…Several studies have indicated its effectiveness in the treatment of disorders such as dystonia, post stroke spasticity, and cerebral palsy to name a few [ 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 ]. The side effect profile of long-term botulinum toxin injections has been well documented, especially in individuals with dystonia and spasticity [ 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 ]. A retrospective longitudinal descriptive analysis by Ramirez-Castenada et al of 89 subjects with dystonia showed that the most common side effects were dysphagia, ptosis, and neck weakness which has been duplicated in several other studies [ 3 , 10 , 11 , 12 ].…”

Section: Introductionmentioning

confidence: 99%

Botulinum Toxin Induced Atrophy: An Uncharted Territory

Salari

Sharma

Jog

2018

Toxins

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Botulinum neurotoxins (BoNTs) produce local chemo-denervation by cleaving soluble N-ethylmaleimide-sensitive factor activating protein receptor (SNARE) proteins. Botulinum neurotoxins are therapeutically indicated in several neurological disorders and have been in use for three decades. The long-term efficacy, safety, and side effects of BoNTs have been well documented in the literature. However, the development of muscle atrophy following chronic exposure to BoNTs has not received sufficient attention. Muscle atrophy is not only cosmetically distressing, but also has an impact on future injections. An extensive literature search was conducted on atrophy and mechanisms of atrophy. Five hundred and four relevant articles in the English language were reviewed. This review revealed the surprising lack of documentation of atrophy within the literature. In addition, as demonstrated in this review, the mechanisms and the clinical factors that may lead to atrophy have also been poorly studied. However, even with this limited information it is possible to indicate factors that could modify the clinical approach to botulinum toxin injections. This review highlights the need for further study of atrophy following BoNT injections.

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Botulinum toxin type A in the treatment of lower limb spasticity in children with cerebral palsy

Blumetti

Belloti

Tamaoki

et al. 2019

Cochrane Database of Systematic Reviews

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AbobotulinumtoxinA Efficacy and Safety in Children With Equinus Foot Previously Treated With Botulinum Toxin

Cited by 6 publications

References 11 publications

The Role of Botulinum Toxin Type-A in Spasticity: Research Trends from a Bibliometric Analysis

The Role of Botulinum Toxin Type-A in Spasticity: Research Trends from a Bibliometric Analysis

Botulinum Toxin Induced Atrophy: An Uncharted Territory

Botulinum toxin type A in the treatment of lower limb spasticity in children with cerebral palsy

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