Absence of bovine leukemia virus proviral DNA in Japanese human blood cell lines and human cancer cell lines

Saito, Susumu; Kitamura-Muramatsu, Yuri; Komine, Fumiko; Polat, Meripet; Takeshima, Shin‐nosuke; Takei, Masami; Aida, Yoko

doi:10.1007/s00705-019-04474-9

Cited by 6 publications

(9 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Most recently, the absence of BLV DNA in Japanese human cell lines was reported [ 27 ]. Authors examined DNA extracted from 145 cell lines yet did not detect any BLV DNA.…”

Section: Resultsmentioning

confidence: 99%

Bovine leukemia virus relation to human breast cancer: Meta-analysis

Gao¹,

Kouznetsova

Tsigelny

2020

Microbial Pathogenesis

View full text Add to dashboard Cite

Bovine leukemia virus (BLV) is a virus that infects cattle around the world and is very similar to the human T-cell leukemia virus (HTLV), which causes adult T-cell leukemia/lymphoma (ATL). Recently, presence of BLV DNA and protein was demonstrated in commercial bovine products and in humans. BLV DNA is generally found at higher rates in humans who have or will develop breast cancer, according to research done with subjects from several countries. These findings have led to a hypothesis that BLV transmission plays a role in breast cancer oncogenesis in humans. Here we summarize the current knowledge in the field.

show abstract

“…Most recently, the absence of BLV DNA in Japanese human cell lines was reported [ 27 ]. Authors examined DNA extracted from 145 cell lines yet did not detect any BLV DNA.…”

Section: Resultsmentioning

confidence: 99%

Bovine leukemia virus relation to human breast cancer: Meta-analysis

Gao¹,

Kouznetsova

Tsigelny

2020

Microbial Pathogenesis

View full text Add to dashboard Cite

show abstract

“…While controversial, several lines of evidence have emerged in recent years suggesting a connection between BLV and human breast cancer ( 101 , 102 ). It is important to note that while multiple groups have reported significant associations between the presence of BLV DNA in human breast cancers ( 103 – 105 ), multiple other groups have found no association ( 106 – 108 ). The potential link between BLV and human breast cancer requires further cautious analysis, and confirmation of the integration of BLV into the genome of human cancer cells, which is necessary for productive infection, and the expression of viral proteins associated with oncogenesis, remains to be demonstrated.…”

Section: A Threat Waiting In the Wings? Is There Potential For Human Infection?mentioning

confidence: 99%

Retroviruses of Bats: a Threat Waiting in the Wings?

Hayward

Tachedjian

2021

mBio

View full text Add to dashboard Cite

show abstract

“…Moreover, in Australia and Colombia, BLV presence has been found ( Giovanna et al, 2013 ; Buehring et al, 2017 ). In China and Japan, BLV has not been found in breast cancer samples ( Zhang et al, 2016 ; Saito et al, 2020 ). The one reason which can justify the absence of virus in Chinese people is their lactose intolerance, due to which milk consumers are significantly low in China ( Gao et al, 2020 ).…”

Section: Bovine Leukaemia Virus and Breast Cancermentioning

confidence: 99%

Interrelated Oncogenic Viruses and Breast Cancer

Afzal

Fiaz

Noor

et al. 2022

Front. Mol. Biosci.

View full text Add to dashboard Cite

Breast Cancer is a multifactorial disease and recent evidence that viruses have a greater role in its aetiology and pathophysiology than previously hypothesized, has garnered a lot of attention in the past couple of years. After the role of Mouse Mammary Tumour Virus (MMTV) in the oncogenesis of breast cancer has been proved in mice, search for similar viruses found quite a plausible relation of Human Papilloma Virus (HPV), Epstein–Barr virus (EBV), and Bovine Leukaemia Virus (BLV) with breast cancer. However, despite practical efforts to provide some clarity in this issue, the evidence that viruses cause breast cancer still remains inconclusive. Therefore, this article aims to clarify some ambiguity and elucidate the correlation of breast cancer and those particular viruses which are found to bring about the development of tumorigenesis by a previous infection or by their own oncogenic ability to manipulate the molecular mechanisms and bypass the immune system of the human body. Although many studies have reported, both, the individual and co-existing presence of HPV, EBV, MMTV, and BLV in patient sample tissues, particularly in Western women, and proposed oncogenic mechanisms, majority of the collective survey of literature fails to provide a delineated and strong conclusive evidence that viruses do, in fact, cause breast cancer. Measures to prevent these viral infections may curb breast cancer cases, especially in the West. More studies are needed to provide a definite conclusion.

show abstract

Absence of bovine leukemia virus proviral DNA in Japanese human blood cell lines and human cancer cell lines

Cited by 6 publications

References 36 publications

Bovine leukemia virus relation to human breast cancer: Meta-analysis

Bovine leukemia virus relation to human breast cancer: Meta-analysis

Retroviruses of Bats: a Threat Waiting in the Wings?

Interrelated Oncogenic Viruses and Breast Cancer

Contact Info

Product

Resources

About