Absence of clinical relationship between oxidized low density lipoproteins and diabetic peripheral neuropathy: a case control study

Rosales-Hernandez, Alma; Cheung, Audrey; Podgorny, Peter; Chan, Cynthia; Toth, Cory

doi:10.1186/1476-511x-13-32

Cited by 11 publications

(13 citation statements)

References 61 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition, OxLDL correlate with symptom severity in patients with fibromyalgia (20,21). However, oxidized LDL levels remain comparable in patients with and without polyneuropathy due to type 2 diabetes (22). Notably, OxPL levels also rise in many other diseases (13).…”

Section: Oxidized Phospholipids Are Linked To Inflammatory Conditions and Painmentioning

confidence: 99%

Pain Control by Targeting Oxidized Phospholipids: Functions, Mechanisms, Perspectives

et al. 2021

View full text Add to dashboard Cite

Within the lipidome oxidized phospholipids (OxPL) form a class of chemically highly reactive metabolites. OxPL are acutely produced in inflamed tissue and act as endogenous, proalgesic (pain-inducing) metabolites. They excite sensory, nociceptive neurons by activating transient receptor potential ion channels, specifically TRPA1 and TRPV1. Under inflammatory conditions, OxPL-mediated receptor potentials even potentiate the action potential firing rate of nociceptors. Targeting OxPL with D-4F, an apolipoprotein A-I mimetic peptide or antibodies like E06, specifically binding oxidized headgroups of phospholipids, can be used to control acute, inflammatory pain syndromes, at least in rodents. With a focus on proalgesic specificities of OxPL, this article discusses, how targeting defined substances of the epilipidome can contribute to mechanism-based therapies against primary and secondary chronic inflammatory or possibly also neuropathic pain.

show abstract

Section: Oxidized Phospholipids Are Linked To Inflammatory Conditions and Painmentioning

confidence: 99%

Pain Control by Targeting Oxidized Phospholipids: Functions, Mechanisms, Perspectives

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Finally, 38 studies were selected to find a relationship between LDL and SBP levels and risk of diabetic peripheral neuropathy [4–17, 22, 33–55]. Of the 38 finalized studies, 2 studies [22, 55] and 7 studies [6, 10, 14–16, 35, 47, 50, 52] were excluded involving insufficient data to find a relationship between LDL and SBP levels and risk of DPN, respectively. Hence, in this current meta-analysis, only 29 articles were attempts to find a relationship between SBP levels and DPN in type 2 diabetes mellitus patients.…”

Section: Resultsmentioning

confidence: 99%

“…)LDL (mmol/L)SBP (mmHg) P -value*N (M/F)Age (yrs. )LDL (mmol/L)SBP (mmHg) P -value**Zhao W. et al [4]365 (230/135)59.482.75 ± 0.86130.29 ± 15.930.01104 (53/51)66.942.62 ± 0.82135.81 ± 17.650.133Wu F. et al [5]560 (338/222)53.202.84 ± 0.96129.10 ± 17.30<0.01574 (307/267)61.002.66 ± 0.95134.4 ± 18.400.002ALMA R. et al [6]12 (6/6)53.602.20 ± 0.70NANA70 (46/24)60.232.30 ± 1.25NANAYang J. et al [7]1287 (626/661)58.612.78 ± 1.01132.06 ± 20.540.03224 (117/107)66.582.75 ± 0.99134.72 ± 22.250.438Bilir B. et al [8]53 (24/29)58.853.59 ± 1.40128.97 ± 11.73NA46 (23/23)56.913.15 ± 0.99131.62 ± 14.25NASharon L. et al [9]1767 (866/901)57.202.76 ± 0.83137.60 ± 18.70< 0.01214 (135/79)60.102.71 ± 0.81146.00 ± 20.600.45Yong J. et al [10]90 (50/40)54.902.90 ± 0.88NANA90 (46/44)54.102.73 ± 0.82NA0.18Su J. et al [11]461 (248/213)56.002.67 ± 0.82134.00 ± 17.000.10102 (51/51)58.402.60 ± 0.86137.00 ± 19.000.44Zhang Y. et al [12]642 (342/300)60.032.92 ± 0.96134.29 ± 19.140.00417 (247/170)61.662.95 ± 1.15142.50 ± 22.390.60Won J. et al [13]2661 (1346/1315)59.402...…”

Section: Resultsmentioning

confidence: 99%

Associations of serum low-density lipoprotein and systolic blood pressure levels with type 2 diabetic patients with and without peripheral neuropathy: systemic review, meta-analysis and meta-regression analysis of observational studies

et al. 2019

View full text Add to dashboard Cite

BackgroundCompositional abnormalities in lipoproteins and cardiovascular risk factors play an important role in the progression of diabetic peripheral neuropathy (DPN). This systematic review aimed to estimate the predicting value of low-density lipoprotein (LDL) and systolic blood pressure (SBP) level in type-2 diabetes mellitus (T2DM) patients with and without peripheral neuropathy. We also tried to determine whether LDL and SBP are associated with an increased collision risk of DPN.MethodsA systematic search was conducted for eligible publications which explored the LDL and SBP level in T2DM patients with and without peripheral neuropathy. The quality of the included studies was assessed by the QUADAS-2 tool. The standardized mean difference (SMD) with 95% CI of LDL and SBP level were pooled to assess the correlation between LDL and SBP level with DPN. We performed random effects meta-regression analyses to investigate factors associated with an increased collision risk of DPN.ResultsThere was a significant association between LDL and SBP with poor prognosis of DPN in those included studies (I2 = 88.1% and I2 = 84.9%, respectively, Both P < 0.001). European T2DM patients have higher serum level of LDL in compare with the European DPN patients (SMD = 0.16, 95% CI: − 0.06 - 0.38; P < 0.001). SBP level was associated with a 2.6-fold decrease in non-DPN patients of T2DM (SMD = − 2.63, 95% CI: − 4.00 - -1.27, P < 0.001). Old age European T2DM patients have significantly high risk for diabetes drivers. Furthermore, the results of the case-control study design model are more precise to show the accuracy of SBP in Asian T2DM patients.ConclusionOur finding supports the LDL and SBP status could be associated with increased risk of peripheral neuropathy in T2DM patients.

show abstract

“…They concluded that low levels of HDL increased the risk of diabetic peripheral neuropathy [ 13 ]. Rosales-Hernandez et al after examining oxidized LDL (OxLDL) in diabetic peripheral neuropathy concluded that there was no association between its level and occurring peripheral neuropathy [ 14 ].…”

Section: Discussionmentioning

confidence: 99%

Designing a Logistic Regression Model for a Dataset to Predict Diabetic Foot Ulcer in Diabetic Patients: High-Density Lipoprotein (HDL) Cholesterol Was the Negative Predictor

Ahmadi

Shirzadegan

Mousavi

et al. 2021

Journal of Diabetes Research

View full text Add to dashboard Cite

Objectives. Although the risk factors for diabetic neuropathy and diabetic foot ulcer have been detected, there was no practical modeling for their prediction. We aimed to design a logistic regression model on an Iranian dataset to predict the probability of experiencing diabetic foot ulcers up to a considered age in diabetic patients. Methods. The present study was a statistical modeling on a previously published dataset. The covariates were sex, age, body mass index (BMI), fasting blood sugar (FBS), hemoglobin A1C (HbA1C), low-density lipoprotein (LDL), high-density lipoprotein (HDL), triglyceride (TG), insulin dependency, and statin use. The final model of logistic regression was designed through a manual stepwise method. To study the performance of the model, an area under receiver operating characteristic (AUC) curve was reported. A scoring system was defined according to the beta coefficients to be used in logistic function for calculation of the probability. Results. The pretest probability for the outcome was 30.83%. The final model consisted of age ( β 1 = 0.133 ), BMI ( β 2 = 0.194 ), FBS ( β 3 = 0.011 ), HDL ( β 4 = − 0.118 ), and insulin dependency ( β 5 = 0.986 ) ( P < 0.1 ). The performance of the model was definitely acceptable ( AUC = 0.914 ). Conclusion. This model can be used clinically for consulting the patients. The only negative predictor of the risk is HDL cholesterol. Keeping the HDL level more than 50 (mg/dl) is strongly suggested. Logistic regression modeling is a simple and practical method to be used in the clinic.

show abstract

Absence of clinical relationship between oxidized low density lipoproteins and diabetic peripheral neuropathy: a case control study

Cited by 11 publications

References 61 publications

Pain Control by Targeting Oxidized Phospholipids: Functions, Mechanisms, Perspectives

Pain Control by Targeting Oxidized Phospholipids: Functions, Mechanisms, Perspectives

Associations of serum low-density lipoprotein and systolic blood pressure levels with type 2 diabetic patients with and without peripheral neuropathy: systemic review, meta-analysis and meta-regression analysis of observational studies

Designing a Logistic Regression Model for a Dataset to Predict Diabetic Foot Ulcer in Diabetic Patients: High-Density Lipoprotein (HDL) Cholesterol Was the Negative Predictor

Contact Info

Product

Resources

About