Absence of close linkage between maternal genes for susceptibility to pre-eclampsia/eclampsia and HLA DRβ

Wilton, Alan N.; Cooper, Desmond W.; Marshall, Philip Guy; Brennecke, Shaun P.; Bishop, S

doi:10.1016/0140-6736(90)92149-c

Cited by 50 publications

(20 citation statements)

References 22 publications

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“…In order to ensure homogeneity of ethnic background and to reduce genetic variability, all subjects studied were white and of Anglo-Saxon extraction, with the exception of 1 Maltese and 2 Italian. The majority of these subjects have been part of our ongoing investigation into the genetic basis of PE/E [2,4,13,18,19]. Diagnosis was based on clinical assessment using the criteria of the Australasian Society for the Study of Hypertension in Pregnancy [20].…”

Section: Methodsmentioning

confidence: 99%

Methylenetetrahydrofolate Reductase Polymorphisms Are Not a Risk Factor for Pre-Eclampsia/Eclampsia in Australian Women

Kaiser

Brennecke

Moses³

2000

Gynecol Obstet Invest

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In European and Japanese but not in Australian, American, and South African women, the C677T methylenetetrahydrofolate reductase (MTHFR) polymorphism has been reported to be a genetic risk factor pre-eclampsia/eclampsia (PE/E). The recently described A1298C MTHFR gene polymorphism also results in reduced MTHFR enzyme activity, although to a lesser extent than the previously described C677T polymorphism. Heterozygotes for both polymorphisms are reported to have an even lower MTHFR enzymatic activity than seen in homozygotes for the C677T genotype. In this current study we determined the allele frequency of the A1298C MTHFR gene polymorphism in an Australian population and examined this polymorphism alone and in combination with the C677T MTHFR polymorphism for an association with PE/E. Neither the A1298C polymorphism alone nor a combination of both polymorphisms showed an association with PE/E in our population of Australian women.

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Section: Methodsmentioning

confidence: 99%

Methylenetetrahydrofolate Reductase Polymorphisms Are Not a Risk Factor for Pre-Eclampsia/Eclampsia in Australian Women

Kaiser

Brennecke

Moses³

2000

Gynecol Obstet Invest

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“…1,2 A variety of preeclampsia candidate genes such as HLA-DRbeta, HLA-G and the tumor necrosis factor alpha gene (chromosome 6), the angiotensin-converting enzyme gene (chromosome 17) and the CuZn superoxide dismutase gene (chromosome 21) have been examined on the basis of their pathophysiological effects, but so far evidence of association or linkage has been ambiguous, presumably because of differences in populations, small effects of disease alleles on risk, and confounding effects caused by gene-environment interactions. [3][4][5][6][7] The genes for factor 5 and methylenetetrahydrofolate reductase lie on chromosome 1. Both have polymorphisms present at a significantly higher frequency in preeclamptic women, and it is likely that they are predisposing factors as regards the development of preeclampsia, without the necessity for it.…”

Section: Introductionmentioning

confidence: 99%

Microsatellite marker association at chromosome region 2p13 in Finnish patients with preeclampsia and obstetric cholestasis suggests a common risk locus

et al. 2003

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The pathophysiology of preeclampsia is incompletely understood, but the familial nature of the disease has long been recognized. Recent genome-scan studies have indicated linkage at the p23 region of chromosome 2. We have previously reported microsatellite marker association at chromosome region 2p13 in patients with obstetric cholestasis. We conducted population-based association screening with microsatellite markers to find potential preeclampsia-associated loci on chromosome region 2p13-p12 and to test whether preeclampsia and obstetric cholestasis share a single risk locus. The study was carried out among 115 unrelated control women, 133 preeclamptic women and 57 cholestatic women. Screening with microsatellite markers at the 2p13-p12 region revealed that the marker D2S286 was significantly associated with obstetric cholestasis in the overall association analysis (P ¼ 0.03), while it revealed only borderline association with preeclampsia (P ¼ 0.08). However, single allele association analysis indicated that both preeclampsia and obstetric cholestasis showed a statistically significant association with a common allele (P o 0.05), which was overrepresented in both the obstetric cholestasis (0.42) and preeclamptic (0.37) groups when compared with the control group (0.28). In conclusion, These findings suggest a possible genetic link between chromosome region 2p13-p12, preeclampsia and obstetric cholestasis. More specifically, these data suggest that there may be a common risk locus associated with both obstetric complications located in the vicinity of the 2p13-p12 association region.

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“…In order to ensure homogeneity of ethnic background and to reduce genetic variability, all subjects studied were white and of Anglo-Saxon extraction, with the exception of 1 Maltese and 2 Italians. The majority of these subjects have been part of our ongoing investigation into the genetic basis of PE/E [11, 12, 13, 14]. …”

Section: Introductionmentioning

confidence: 99%

C677T Methylenetetrahydrofolate Reductase Polymorphism Is Not a Risk Factor for Pre-Eclampsia/Eclampsia among Australian Women

Kaiser¹,

Brennecke²,

Moses³

2000

Hum Hered

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The C677T methylenetetrahydrofolate reductase (MTHFR) gene polymorphism results in reduced MTHFR enzymatic activity. This in turn results in increased levels of homocysteine. It has been suggested that increased levels of homocysteine cause vascular disease, which is known to increase the risk of developing pre-eclampsia (PE) during pregnancy. However, recent studies on Japanese, Italian and American populations have failed to reach agreement on an association between the C677T polymorphism and PE. In this study, 156 cases of eclampsia (E)/PE and 79 normal pregnant control cases from an Australian population were genotyped for this mutation. No significant difference could be found in the incidence of the homozygote mutation or in the allele frequency. We conclude from this study that the C677T mutation in our population is not associated with the development of PE/E.

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Absence of close linkage between maternal genes for susceptibility to pre-eclampsia/eclampsia and HLA DRβ

Cited by 50 publications

References 22 publications

Methylenetetrahydrofolate Reductase Polymorphisms Are Not a Risk Factor for Pre-Eclampsia/Eclampsia in Australian Women

Methylenetetrahydrofolate Reductase Polymorphisms Are Not a Risk Factor for Pre-Eclampsia/Eclampsia in Australian Women

Microsatellite marker association at chromosome region 2p13 in Finnish patients with preeclampsia and obstetric cholestasis suggests a common risk locus

C677T Methylenetetrahydrofolate Reductase Polymorphism Is Not a Risk Factor for Pre-Eclampsia/Eclampsia among Australian Women

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