Absence of genotoxic effects of the chalcone (E)-1-(2-hydroxyphenyl)-3-(4-methylphenyl)-prop-2-en-1-one) and its potential chemoprevention against DNA damage using in vitro and in vivo assays

Lima, Débora Cristina da Silva; Vale, Camila Regina do; Véras, Jefferson Hollanda; Bernardes, Aline; Pérez, Caridad N.; Chen-Chen, Lee

doi:10.1371/journal.pone.0171224

Cited by 22 publications

(11 citation statements)

References 60 publications

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“…Several natural products have shown an ability to decrease MN frequency provoked by CP, although practically all compounds must be administered before CP to show their chemoprotective effect [ 63 , 64 , 65 , 66 , 67 , 68 ]. Others, such as water-soluble tannins and triterpenoid saponins, have shown effectiveness when administered at the same time as CP (co-treatment), but only a few examples show a CP protective effect post-treatment [ 69 , 70 , 71 ].…”

Section: Discussionmentioning

confidence: 99%

AgNPs Argovit™ Modulates Cyclophosphamide-Induced Genotoxicity on Peripheral Blood Erythrocytes In Vivo

et al. 2021

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Silver nanoparticles (AgNPs) have been studied worldwide for their potential biomedical applications. Specifically, they are proposed as a novel alternative for cancer treatment. However, the determination of their cytotoxic and genotoxic effects continues to limit their application. The commercially available silver nanoparticle Argovit™ has shown antineoplastic, antiviral, antibacterial, and tissue regenerative properties, activities triggered by its capacity to promote the overproduction of reactive oxygen species (ROS). Therefore, in this work, we evaluated the genotoxic and cytotoxic potential of the Argovit™ formulation (average size: 35 nm) on BALB/c mice using the micronucleus in a peripheral blood erythrocytes model. Besides, we evaluated the capability of AgNPs to modulate the genotoxic effect induced by cyclophosphamide (CP) after the administration of the oncologic agent. To achieve this, 5–6-week-old male mice with a mean weight of 20.11 ± 2.38 g were treated with water as negative control (Group 1), an single intraperitoneal dose of CP (50 mg/kg of body weight, Group 2), a daily oral dose of AgNPs (6 mg/kg of weight, Group 3) for three consecutive days, or a combination of these treatment schemes: one day of CP doses (50 mg/kg of body weight) followed by three doses of AgNPs (one dose per day, Group 4) and three alternate doses of CP and AgNPs (six days of exposure, Group 5). Blood samples were taken just before the first administration (0 h) and every 24 h for seven days. Our results show that Argovit™ AgNPs induced no significant cytotoxic or acute genotoxic damage. The observed cumulative genotoxic damage in this model could be caused by the accumulation of AgNPs due to administered consecutive doses. Furthermore, the administration of AgNPs after 24 h of CP seems to have a protective effect on bone marrow and reduces by up to 50% the acute genotoxic damage induced by CP. However, this protection is not enough to counteract several doses of CP. To our knowledge, this is the first time that the exceptional chemoprotective capacity produced by a non-cytotoxic silver nanoparticle formulation against CP genotoxic damage has been reported. These findings raise the possibility of using AgNPs as an adjuvant agent with current treatments, reducing adverse effects.

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Section: Discussionmentioning

confidence: 99%

AgNPs Argovit™ Modulates Cyclophosphamide-Induced Genotoxicity on Peripheral Blood Erythrocytes In Vivo

et al. 2021

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“…The antigenotoxic activity of D. cachrydifolia was determined with the A. cepa chromosomal aberration assay according to Lima et al (2017), compounds that prevent mutagenic or genotoxic events from affecting DNA can act by various mechanisms which are usually detected in pre-treatment or co-treatment. Other substances are effective by promoting DNA repair after damage has occurred and can be detected in post-treatment.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of biological activity of Diplotaenia cachrydifolia Boiss. that medicinal plant

Uğraş¹,

Ulger²,

Rasgele³

2019

Istanbul J Pharm

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In a modern context, at least 25% of the active ingredients of pharmacologically produced medicines are derived from plants. In addition, the active ingredients of many synthetically produced medicines are similar to chemicals that were first isolated from medicinal plants (Berber et al. 2013). The active ingredients in medicinal plants have been shown to exhibit high biological capability (Bhouri et al. 2010; Kilani-Jaziri et al. 2011) and these plants seem to be the best resources for the discovery of novel bioactive chemicals in the design of new drugs. Recently, there has been considerable interest in the antimicrobial (Rates 2001), antioxidative (Kilani-Jaziri et al. 2011) and antigenotoxic activities (Amkiss et al. 2013) of medicinal plants. At present, alternative antimicrobial medicines are needed, in particular, for the treatment of infectious diseases. Mounting resistance of microorganisms to many antibiotics has led to increasing difficulties in the treatment of infectious diseases. In this context, local medicinal plants are known to be rich in antimicrobial properties and thus, a source of novel antimicrobials (Rates 2001; Kilani-Jaziri et al. 2011). Furthermore, some medicinal plants are reported to exhibit high antioxidant activity (Kilani-Jaziri et al. 2011), and plant phenolics are generally the source of these natural antioxidant properties (Atoui et al. 2005; Cavlak and Yagmur 2016). Antioxidants prevent the formation of free radicals produced routinely in all cells as part of their normal function; however, free radical accumulation in cells may play a role in many diseases (Young and Woodside 2001). Recently, there has been a growing interest in natural antioxidants of plant origin. Natural antioxidants obtained from medicinal plants can prevent the formation of free radicals, thus indicating their potential as novel therapeutic agents (Nogochi and Nikki 2000; Chaabane et al. 2012). Of late, considerable research has been focused on the antigenotoxic activity of medicinal

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“…Todos os compostos foram testados quanto à sua atividade anticonvulsivante utilizando testes de convulsão induzida por PTZ e MES em camundongos a uma dose de 50 mg kg -1 via intraperitoneal. Os resultados da atividade anticonvulsivante demonstraram que entre os compostos testados, os derivados de 2pirazolina-1-carboxamida que transportam 5-Bromotiofen-2-il (22) e o 5-Clorotiofen-2-il (23) (Figura 14) exibiram promissora atividade no teste PTZ, uma vez que reduziram a frequência de convulsão em todos os graus (1)(2)(3)(4)(5). Assim, pode-se concluir que os referidos compostos aumentaram o limite convulsivo e prolongaram o tempo de início de 1,20 a 2,10 e 1,20 a 3,58 segundos, assim como aumentaram a taxa de sobrevivência quase duas vezes de 50 % a 95 % e 50 % a 100 %, respectivamente.…”

Section: Atividade Anticonvulsivanteunclassified

“…Constituem uma classe de flavonoides de cadeia aberta, abundantemente encontradas em plantas das famílias Leguminosae, Compositae e Moraceae, presente em frutas, vegetais, grãos, raízes, flores, chás, vinhos, produtos estes regularmente utilizados para consumo humano. 2 Nas flores, uma característica marcante é a sua capacidade de conferir pigmento amarelo às pétalas de algumas plantas de uso medicinal, auxiliando também na polinização como atraentes de insetos e/ou pássaros. 1,2…”

Section: Introductionunclassified

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Chalcones Pharmacological Potential: A Brief Review

et al. 2018

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Chalcones are naturally occurring aromatic ketones, consisting of an α, β-unsaturated carbonyl system linking two aromatic rings. It is a class of open chain flavonoids, abundantly found in plants of the families Leguminosae, Compositae and Moraceae, and present in fruits, vegetables, grains, roots, flowers, teas, wines, products regularly used for human consumption. Research that investigates the properties of chalcones has shown a broad spectrum of biological activity, which has been reinforcing since the isolation, synthesis, identification and investigation of biological effects. This study was carried out based on the scientific articles published on chalcones, emphasizing the following pharmacological activities: antioxidant, antinociceptive, anti-inflammatory, anxiolytic and anticonvulsant compared to the period of the last 10 years. It was verified that the reported activities prove that chalcones and their derivatives are substances of great chemical-pharmacological interest.

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Absence of genotoxic effects of the chalcone (E)-1-(2-hydroxyphenyl)-3-(4-methylphenyl)-prop-2-en-1-one) and its potential chemoprevention against DNA damage using in vitro and in vivo assays

Cited by 22 publications

References 60 publications

AgNPs Argovit™ Modulates Cyclophosphamide-Induced Genotoxicity on Peripheral Blood Erythrocytes In Vivo

AgNPs Argovit™ Modulates Cyclophosphamide-Induced Genotoxicity on Peripheral Blood Erythrocytes In Vivo

Evaluation of biological activity of Diplotaenia cachrydifolia Boiss. that medicinal plant

Chalcones Pharmacological Potential: A Brief Review

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