Absence of long-term effects of reproduction on longevity in the mouse model

Tarı́n, Juan J.; Gómez-Piquer, Vanessa; García-Palomares, Silvia; Garcı́a-Pérez, Miguel A.; Cano, Antonio

doi:10.1186/1477-7827-12-84

Cited by 13 publications

(13 citation statements)

References 21 publications

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“…In Alpine Ibex, there was no survival CoR either before or after an epizootic event (pneumonia), but the cost was high during it (Garnier, Gaillard, Gauthier, & Besnard, 2016). By contrast, studies on captive populations, where resources (at least food and water) can be considered as non-limiting, failed to detect any CoR in 18 mammal and 12 bird species kept in zoos (Ricklefs & Cadena, 2007), in Rottweiler pet dogs (Kengeri, Maras, Suckow, Chiang, & Waters, 2013), in laboratory mice (Tarin, Gomez-Piquer, Garcia-Palomares, Garcia-Perez, & Cano, 2014) and captive Microcebus murinus (Landes, Henry, Hardy, Perret, & Pavard, 2019). However, dependence of survival CoR on resource abundance is not universal: reproduction was not more costly under unfavourable or favourable environmental conditions in American red squirrels (Descamps, Boutin, McAdam, Berteaux, & Gaillard, 2009).…”

Section: Poor Environmental Conditions Can Reveal Otherwise Hidden mentioning

confidence: 99%

Are trade‐offs really the key drivers of ageing and life span?

Cohen

Coste

et al. 2019

Functional Ecology

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1. Current thinking in life-history theory and the biology of ageing suggests that ageing rates, and consequently life spans, evolve largely as a function of trade-offs with reproduction. While various evolutionary constraints are generally acknowledged to exist, their potential role in determining ageing rates is rarely considered.2. This review integrates three types of information to assess the relative importance of constraints and trade-offs in shaping ageing rates: (a) empirical work on the presence of intraspecific trade-offs; (b) theoretical work on factors limiting the force of trade-offs; and (c) consideration of the biological mechanisms of ageing, as currently understood. 3. At the empirical level, evidence for intraspecific trade-offs is mixed, including some surprising failures to observe a trade-off in model organisms. At the theoretical level, the presence of multiple currencies and nonlinearity can weaken the strength and/or generality of trade-offs. Additionally, trade-offs among lowerlevel functions, such as between sources of mortality, can create constraints at higher organizational levels, for example such that reductions in reproduction are unable to produce decreases in ageing rate. In terms of ageing mechanisms, some mechanisms, such as the regulation of IGF-1 and related pathways, seem to agree quite well with trade-offs as a driving force; however, other mechanisms, such as dysregulation of the vertebrate stress response and stem cell exhaustion, seem more likely to impose constraints than to mediate trade-offs. 4. Taken together, these findings suggest that trade-offs alone are insufficient to understand how ageing rates evolve; instead, both trade-offs and constraints likely play important roles in shaping evolutionary patterns, with their relative importance varying across taxa. Accordingly, it is time to revisit the broad assumption that survival-reproduction trade-offs are the key force structuring much of lifehistory variation and the evolution of ageing rates. K E Y W O R D S ageing, constraint, cost of reproduction, disposable soma, life history, physiology, senescence, trade-off 154 | Functional Ecology COHEN Et al. | 155Functional Ecology COHEN Et al. | 157Functional Ecology COHEN Et al.

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Section: Poor Environmental Conditions Can Reveal Otherwise Hidden mentioning

confidence: 99%

Are trade‐offs really the key drivers of ageing and life span?

Cohen

Coste

et al. 2019

Functional Ecology

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“…Following a surge of empirical work driven by theoretical advances and syntheses, this trade‐off once appeared nearly universal (Reznick, ; Stearns, ; Reznick, Nunney & Tessier, ). However, some more recent counterexamples have challenged this consensus, highlighting the need for more attention to this fundamental assumption of life‐history theory (Reznick et al ., ; Flatt, ; Wit et al ., ; Tarín et al ., ). Sampling across taxonomic and functional groups is needed to test for (near) universality of a trade‐off, to identify patterns in when, where, and to what extent the trade‐off occurs, and to reveal potential underlying mechanisms (Reznick, ).…”

Section: Introductionmentioning

confidence: 97%

Both sexes pay a cost of reproduction in a frog with biparental care

Dugas

Wamelink

Richards‐Zawacki

2015

Biol J Linn Soc Lond

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The assumption that reproduction is costly is central to life-history theory. Good evidence supporting this premise comes from studies, mostly in short-lived invertebrates, demonstrating a negative relationship between reproduction and longevity. Whether this trade-off operates broadly, for example in males and females and in short-and long-lived organisms, remains unresolved. We found a negative relationship between reproduction and days survived in captive, wild-caught, individuals of a long-lived poison frog with biparental care (Oophaga pumilio). The proportion of time that individuals spent paired and tadpole production rate were negatively associated with days survived in both sexes, and clutch production was negatively associated with days survived in females. These results broaden the taxonomic base upon which this tenet of life-history theory is built, empirically confirm that females of this species should be choosy when selecting mates and caring for offspring, and suggest that the costs of 'limited' male care in this species deserve re-evaluation. Figure 2. The relationships between tadpole production per day and female (A) and male (B) O. pumilio days survived in captivity. Female days survived is presented as residuals from a model that also contained the fixed effects of collection date, clutch production per day and proportion-of-time-paired, while the relationship for males is a linear regression (the best model). The regression line indicates a significant (P < 0.05) relationship. 216 M. B. DUGAS ET AL. REFERENCES Brust DG. 1993. Maternal care by Dendrobates pumilio: a frog that feeds its young. Journal of Herpetology 27: 96-98. Cordts R, Partridge L. 1996. Courtship reduces longevity of male Drosophila melanogaster. Animal Behaviour 52: 270-278. Cornwallis CK, Dean R, Pizzari T. 2014. Sex-specific patterns of aging in sexual ornaments and gametes. American Naturalist 184: E66-E88. Duellman WE, Trueb L. 1986. Biology of Amphibians. Baltimore: Johns Hopkins University Press. Dugas MB, Yeager J, Richards-Zawacki CL. 2013. Carotenoid supplementation enhances reproductive success in the captive strawberry poison frogs (Oophaga pumilio). Zoo Biology 32: 655-658. Flatt T. 2010. Survival costs of reproduction in Drosophila. Experimental Gerontology 46: 369-375. Forslund P, Pärt T. 1995. Age and reproduction in birdshypotheses and tests. Trends in Ecology and Evolution 10: 374-378. Gehara M, Summers K, Brown JL. 2013. Population expansion, isolation and selection: novel insights on the evolution of color diversity in the strawberry poison frog. Evolutionary Ecology 27: 797-824. Gillooly JF, Bayliss JR. 1999. Reproductive success and the energetic cost of parental care in male smallmouth bass. Journal of Fish Biology 54: 573-584. Harshman LG, Zera AJ. 2007. The cost of reproduction: the devil in the details. Trends in Ecology and Evolution 22: 80-86. Hunt J, Brooks R, Jennions MD, Smith MJ, Bentsen CL, Bussière LF. 2001. High-quality male field crickets invest heavily in sexual display but die young. Nat...

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“…Last but not least, in captive populations, resources (food, water, mate, and shelter) are generally provided in sufficient quantity so that they do not limit animal welfare, maintenance, and reproduction. Studies on zoo populations for 18 mammal and 12 bird species (Ricklefs & Cadena, ), on Rottweiler pet dogs (Kengeri, Maras, Suckow, Chiang, & Waters, ) and laboratory mice (Tarin, Gomez‐Piquer, Garcia‐Palomares, Garcia‐Perez, & Cano, ), have actually failed to detect any CoR. Positive relationship between reproductive effort and survival was even found in ruffed lemurs kept in zoos (Tidière, Lemaître, Douay, Whipple, & Gaillard, ).…”

Section: Introductionmentioning

confidence: 99%

Female reproduction bears no survival cost in captivity for gray mouse lemurs

Landes

Henry

Hardy

et al. 2019

Ecology and Evolution

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The survival cost of reproduction has been revealed in many free‐ranging vertebrates. However, recent studies on captive populations failed to detect this cost. Theoretically, this lack of survival/reproduction trade‐off is expected when resources are not limiting, but these studies may have failed to detect the cost, as they may not have fully accounted for potential confounding effects, in particular interindividual heterogeneity. Here, we investigated the effects of current and past reproductive effort on later survival in captive females of a small primate, the gray mouse lemur. Survival analyses showed no cost of reproduction in females; and the pattern was even in the opposite direction: the higher the reproductive effort, the higher the chances of survival until the next reproductive event. These conclusions hold even while accounting for interindividual heterogeneity. In agreement with aforementioned studies on captive vertebrates, these results remind us that reproduction is expected to be traded against body maintenance and the survival prospect only when resources are so limiting that they induce an allocation trade‐off. Thus, the cost of reproduction has a major extrinsic component driven by environmental conditions.

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Absence of long-term effects of reproduction on longevity in the mouse model

Cited by 13 publications

References 21 publications

Are trade‐offs really the key drivers of ageing and life span?

Are trade‐offs really the key drivers of ageing and life span?

Both sexes pay a cost of reproduction in a frog with biparental care

Female reproduction bears no survival cost in captivity for gray mouse lemurs

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