Absolute oral bioavailability and possible metabolic pathway of panduratin A from
            <i>Boesenbergia rotunda</i>
            extract in beagle dogs

Boonyarattanasoonthorn, Tussapon; Kongratanapasert, Teetat; Jiso, Apisada; Techapichetvanich, Pinnakarn; Nuengchamnong, Nitra; Supannapan, Kittitach; Kijtawornrat, Anusak; Khemawoot, Phisit

doi:10.1080/13880209.2023.2190777

Cited by 4 publications

(5 citation statements)

References 27 publications

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“…Such an approach minimizes the risk of adverse events, especially in patients with long COVID. Prior to the present study, a fingerroot extract formulation was developed and evaluated for its efficacy in SARS-CoV-2 infected hamsters, along with pharmacokinetics in healthy dogs [30] . Panduratin A has antiviral and anti-inflammatory activities and pinostrobin exerts good anti-inflammatory activity, but they have limited water solubility [8] , [12] .…”

Section: Discussionmentioning

confidence: 99%

“…The procedure used to develop the fingerroot extract formulation was described by Boonyarattanasoonthorn et al . [30] .…”

Section: Methodsmentioning

confidence: 99%

“…Therefore, we developed a formulation by mixing fingerroot extract with β-cyclodextrin at 1:2 ratio to improve water solubility. This formulation has been tested for oral pharmacokinetics in Beagles, improving tolerability in dogs after consecutive dosing for 7 days [30] . Panduratin A was detected in dog plasma up to 72 h after oral dosing.…”

Section: Introductionmentioning

confidence: 99%

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Oral sub-chronic toxicity of fingerroot (Boesenbergia rotunda) rhizome extract formulation in Wistar rats

Techapichetvanich,

Tangpanithandee,

Supannapan

et al. 2024

Toxicology Reports

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Section: Discussionmentioning

confidence: 99%

“…The procedure used to develop the fingerroot extract formulation was described by Boonyarattanasoonthorn et al . [30] .…”

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Oral sub-chronic toxicity of fingerroot (Boesenbergia rotunda) rhizome extract formulation in Wistar rats

Techapichetvanich,

Tangpanithandee,

Supannapan

et al. 2024

Toxicology Reports

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“…However, the glucuronidation form of panduratin A was not detected in rats but could be found in dogs. 23 The differences in glucuronidation activity between species could be observed even between rodent species. 50 It is noteworthy that the potential biotransformation of Panduratin A has been observed to consist of Phase I metabolism, specifically oxidation.…”

Section: Discussionmentioning

confidence: 99%

“…In our previous study, healthy dogs were injected with 1 mg/kg/day of pure panduratin A and fed with 5 and 10 mg/kg/day of panduratin A-consisted fingerroot extract formulation that showed acceptable pharmacokinetic parameters and possible metabolic pathways. 23 Other research groups have reported pharmacokinetic studies of panduratin A in fingerroot extract using ethanolic extraction with 5–10% w/w in animal models. 24 However, there is a lack of information comparing oral administration of pure panduratin A and panduratin A-consisted fingerroot extract.…”

Section: Introductionmentioning

confidence: 99%

Oral Bioavailability, Tissue Distribution, Metabolism, and Excretion of Panduratin A from Boesenbergia rotunda Extract in Healthy Rats

Kongratanapasert,

Boonyarattanasoonthorn,

Supannapan

et al. 2024

DDDT

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Boesenbergia rotunda (L.) Mansf.: A Review of Phytochemistry, Pharmacology, and Pharmacokinetics

Hop,

The Son

2023

COC

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Boesenbergia rotunda (the family Zingiberaceae) is a well-known medicinal plant from Southeast Asia and China. Its parts, especially the roots, were used as an alternative in cuisine, and flavoring. Many attempts tend to explore its phytochemistry and pharmacological values. The ultimate goal of this review is to critically offer the pharmacological values and mechanisms of action of B. rotunda crude extracts and their isolated compounds. Phytochemical investigation and pharmacokinetics were also discussed.On the basis of the most effective keyword “Boesenbergia rotunda”, the relevant data have been gathered from international electronic sources, including Sci-Finder, Google Scholar, PubMed, and reputation publishers. B. rotunda species was reported to contain two main chemical classes of phenolics and terpenoids. Its constituents have great biological values and spread out to drug development, including anticancer, anti-inflammatory, antimicrobacterial, antioxidative, ani-viral, anti-insect, antidiabetic, anti-allergic, anti-obesity, hepatoprotective, neuroprotective, rhenoprotective, gastroprotective, skin protective, vasorelaxant, and aphrodisiac activities. Various pharmacological actions were successfully proven by the underlying mechanisms. (–)-Panduratin A seems to be the most active compound with an oral bioavailability of 7-9%. B. rotunda plant extracts are safe in use with LD50 > 4.0 g/kg. Pharmacokinetic studies indicated that the metabolism of B. rotunda constituents may be related to the oxidation and glucuronidation of its phenolic compounds. Further phytochemical and pharmacological studies are expected, as well as clinical applications are urgently needed.

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Absolute oral bioavailability and possible metabolic pathway of panduratin A from Boesenbergia rotunda extract in beagle dogs

Cited by 4 publications

References 27 publications

Oral sub-chronic toxicity of fingerroot (Boesenbergia rotunda) rhizome extract formulation in Wistar rats

Oral sub-chronic toxicity of fingerroot (Boesenbergia rotunda) rhizome extract formulation in Wistar rats

Oral Bioavailability, Tissue Distribution, Metabolism, and Excretion of Panduratin A from Boesenbergia rotunda Extract in Healthy Rats

Boesenbergia rotunda (L.) Mansf.: A Review of Phytochemistry, Pharmacology, and Pharmacokinetics

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