Absorption and Metabolism of DDT by Resistant and Susceptible House Flies

Sternburg, J. G.; Kearns, C. W.; Bruce, W. N.

doi:10.1093/jee/43.2.214

Cited by 68 publications

(14 citation statements)

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“…DDT absorption continued rapidly for about one hour after application and thereafter at a slow rate up to about 46% of total applied, after 4 hr. These results are in general agreement with those of Sternburg et al (1950) who found that their susceptible flies absorbed 10% of the applied DDT at "zero" time after application and 60% after 4 hr. The solvent used in their experiments was ethanol.…”

Section: Discussionsupporting

confidence: 92%

“…Although the proportion absorbed after 4 hr was generally similar for each of the strains, very different quantities of DDT were initially applied (0.1, 1 and 10 ~tg/fly), thus the absolute rates of penetration differed strongly. Sternburg et al (1950) also found that the rate of DDT penetration into the fly was related to the amount of DDT on the outside of the body. The rate of absorption was greater at high concentrations.…”

Section: Discussionmentioning

confidence: 88%

“…In the housefly breakdown of DDT to metabolites is accomplished, or at least accelerated by specific dehydrochlorinase enzymes (Perry & Hoskins, 1951, Grigolo et al, 1965, Brooks, 1968; and in some strains by oxidases (Perry & Sacktor, 1955). Sternburg et al (1950) determined DDT absorption and breakdown rates for a resistant strain of housefly (Multi Strain I) and for a laboratory susceptible strain. They found that the rate of absorption of DDT was highest in the first hour after application in both strains and that there was no significant difference between initial absorption rates in the two strains.…”

mentioning

confidence: 99%

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DIEL CHANGES IN DDT ABSORPTION AND BREAKDOWN RATES AND RESPIRATORY RHYTHM IN THE HOUSEFLY, MUSCA DOMESTICA

Shipp

Otton

1976

Entomologia Exp Applicata

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Absorption rates in three strains of housefly show little variation when DDT is applied at different times during the 24‐hr cycle. Rates of breakdown of DDT to DDE, however, vary significantly at different times of the day with most rapid breakdown at 05.00–05.30 and 15.00 hr, corresponding to diel peaks in oxygen consumption. The pre‐dawn peak breakdown rates occur at the times at which the flies were found, previously, to be most susceptible to DDT, thus this change in susceptibility must have other causes. ZUSAMMENFASSUNG TAGESZEITLICHE SCHWANKUNGEN IN DDT‐ABSORPTIONS‐ UND ABBAURATEN UND IM ATMUNGSRHYTHMUS BEI DER STUBENFLIEGE, MUSCA DOMESTICA Die Geschwindigkeit, mit der DDT von drei Stubenfliegenrassen absorbiert wurde, zeigte nur wenig Verschiedenheit, wenn es zu verschiedenen Zeiten im Verlauf des 24‐h‐Tages appliziert wurde. Die Rate des Abbaus von DDT zu DDE variierte dagegen im Lauf des Tages, sie war am grössten um 5.00 bis 5.30 Uhr und um 15.00 Uhr, entsprechend den Tagesspitzen des Sauerstoff‐Verbrauchs. Das erste Abbaumaximum (vor Tagesanbruch) fiel zusammen mit der Zeit, in der die Fliegen höchste Empfindlichkeit gegenüber DDT zeigten (vgl. vorige Veröffentlichung). Diese tageszeitspezifische Empfindlichkeit Hess sich demnach keineswegs mit einer (geringeren) Abbaugeschwindigkeit in Zusammenhang bringen.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 88%

mentioning

confidence: 99%

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DIEL CHANGES IN DDT ABSORPTION AND BREAKDOWN RATES AND RESPIRATORY RHYTHM IN THE HOUSEFLY, MUSCA DOMESTICA

Shipp

Otton

1976

Entomologia Exp Applicata

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“…DDT resistance was first characterized by Sternburg, Kearns, and Bruce (1950) and Perry and Hoskins (1951) as resulting from the accelerated rates of conversion by highly resistant houseflies of DDT to its nontoxic derivative DDE. While the various susceptible strains produced little or apparently no DDE from topically applied DDT, highly resistant strains converted over 50% of absorbed DDT to DDE.…”

Section: Biochemistry Of Ddt Resistancementioning

confidence: 99%

DDT substitutes

Metcalf

Fukuto

1973

C R C Critical Reviews in Environmental Control

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“…Dehydrochlorination is involved in the transformation of DDT to DDE (134,135) and of lindane to pentachlorocyclohexene (136). Reductive de chlorination is involved in the formation of DDD from DDT by yeast (137) and rats (134).…”

Section: Biotransformationmentioning

confidence: 99%

Review of the Metabolism of Chlorinated Hydrocarbon Insecticides Especially in Mammals

Wj¹

1965

Annu. Rev. Pharmacol.

119

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This review discusses the absorption, storage, biotransformation, and excretion of chlorinated hydrocarbon insecticides; thus, it emphasizes those aspects of physiology that can be studied by the methods of analytical or ganic chemistry. The broader aspects of toxicity, as they relate to the me tabolism of these materials, were discussed by Winteringham & Barnes (1).This review emphasizes mammalian metabolism of the compounds, but con tains some information on their metaboli sm by other organisms, a subject that has already been reviewed by Perry (2). In relation to mammals, great est interest centers in numerous repeated doses that produce no obvious in jury and that are so small that they might be encountered under practical conditions in the use of insecticides. For this reason, DDT and related re sidual insecticides are emphasized, but some information is given on the chlorinated hydrocarbon fumigants.

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Absorption and Metabolism of DDT by Resistant and Susceptible House Flies

Cited by 68 publications

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DIEL CHANGES IN DDT ABSORPTION AND BREAKDOWN RATES AND RESPIRATORY RHYTHM IN THE HOUSEFLY, MUSCA DOMESTICA

DIEL CHANGES IN DDT ABSORPTION AND BREAKDOWN RATES AND RESPIRATORY RHYTHM IN THE HOUSEFLY, MUSCA DOMESTICA

DDT substitutes

Review of the Metabolism of Chlorinated Hydrocarbon Insecticides Especially in Mammals

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