Absorption and Synthesis of Immunoglobulins G in Newborn Calves

Abstract

Newborn calves (n=19) got 4.5 liters of pooled colostrum within three feedings in the first 14 hours post natum (p.n.). The immunoglobulin G1 (IgG1) and IgG2 concentrations in the colostrum pool were 54.9 mg/ml and 4.2 mg/ml. The precolostral serum IgG concentrations in calves were 0.15 mg/ml (IgG1; SD 0.24) and 0.06 mg/ml (IgG2; SD 0.14). The highest serum IgG levels p.n. were measured 12 hours after the first colostrum feeding (9.3 mg IgGl/ml (SD 4.0), 0.8 mg IgGl/ml (SD 1.0). Thereafter, the mean IgGl level was reduced continuously to the significant lowest concentration of 4.9 mg/ml (SD 2.3) at day 28 p.n. and then increased continuously to the significant highest concentration of 9.0mg/ml (SD 4.8) on day 77 p.n.. The mean concentration of IgG2 was lowest on day 11 p.n. (0.5 mg/ml; SD 0.4) and highest on day 77 p.n.(1.2 mg/ml; SD 0.6). In blood from 198 calves, housed in Germany and sampled between day 4 and 6 p.n., the IgG concentration averaged 4.9 mg/ml serum (SD 3.3). From 93 dams of these calves a sample of the first colostrum could be obtained showing a mean concentration of 22.0 mg IgG/ml (SD 11.0). IgG levels in the colostrum and in the serum showed a correlation of r=0.37. In Kenia IgG levels of three week old calves from two farms were measured. The calves were always with mother for the first 24 hours. The mean serum IgG concentrations of the calves were 22.5 mg IgG/ml (n=7, SD 6.8) and 15.2 mg IgG/ml (n=15; SD 6.3). Comparing to the serum IgG levels found in calves of our studies in Germany there were significant differences.

Technical note: Serum total protein and immunoglobulin G concentrations in neonatal dairy calves over the first 10 days of age

“…Our study is the first to evaluate passive transfer status in the same individual over the first 10 d of life. The data from this study confirm and expand upon other reports on the decline in concentrations of maternal antibodies in newborn calves after birth, indicating a marked decline occurring around 10 d of age (Erhard et al, 1999;Hassig et al, 2007).…”

“…Accurate measures of passive transfer of immunity must occur before this onset of active immunity. Also, maternal colostrum IgG has a half-life of approximately 10 d (Erhard et al, 1999;Hassig et al, 2007). Thus, some researchers have suggested that IgG should be measured by 7 d of age (McGuirk and Collins, 2004;Godden, 2008), whereas others have sampled earlier (Villarroel et al, 2013) or as late as 21 d of age (Tyler et al, 1999).…”

Effect of Prepartum Supplementation of Yeast Culture (Saccharomyces Cerevisiae) on Biochemical Parameters of Dairy Cows and Their Newborn Calves

“…Bárta et al (2008) claim an average IgG value for a healthy calf to be 12.74 g/l. In a attempt to Erhard et al (1999) measured a higher average value og the calves 22.5 mg IgG/ml (n = 7, SD = 6.8). This values are little higher than our measurements.…”

PROFIL IMUNOGLOBULIN M (IgM) SAPI BALI DI NUSA PENIDA KABUPATEN KLUNGKUNG PROVINSI BALI

“…Hal itu sejalan dengan studi sebelumnya oleh jazek et al, (2012) bahwa sapi di usia muda memiliki kadar immunoglobulin lebih rendah dibandingkan dengan usia dewasa. Hal itu dipengaruhi oleh transfer pasif kolostrum pada saat usia muda, sedangkan saat usia dewasa sapi sudah terjadi auto-sintesis immunoglobulin (Erhard et al, 1999). Akan tetapi faktor lain seperti adanya infeksi oleh parasit juga dapat mempengaruhi kadar IgM dan IgG serum sapi (Arlian, 1996).…”