Abstract P1-17-02: Male breast carcinoma: A clinicopathological and immunohistochemical characterization study

Abstract

Male breast carcinoma is a relatively rare disease. This study retrospectively investigated the clinicopathological features of 73 cases of male breast carcinoma in Chinese population, and classified the molecular subtype based on surrogate immunohistochemical definitions. The expression of GCDFP15, MGB, AR and FOXP1 were evaluated. Invasive carcinoma of no special type was the most common histological type in the study group (71.2%, 52/73). The luminal A and B subtypes were the major types of male breast carcinoma (60.9%, 34.8% respectively). AR and FOXP1 are expressed in 84.2% (48/57) and 71.9% (41/57) of the studied cases. Carcinoma of the luminal A subtype expressed GCDFP15 (73.5%, 25/34) and MGB (58.8%, 20/34) more frequently than cases of the luminal B subtypes (34.8%, 8/23 and 43.5%, 10/23, respectively; P = 0.004, P = 0.255, respectively). In conclusion, invasive carcinoma of no special type was the most common histological type in male breast carcinoma among Chinese population. Our study revealed that the luminal A and B subtypes were the major types of male breast carcinoma. AR and FOXP1 are highly expressed in male breast cancer. The luminal A subtype tends to express GCDFP15 and MGB more frequently than the luminal B subtype.

Male Breast Cancer: a 24 Year Experience of a Tertiary Care Hospital in Pakistan

“…The occurrence of lobular carcinoma in MBC is still rare. (Giordano et al, 2004;Chikaraddi et al, 2012;Zhou et al, 2014) Most of our patients had IDC and we did not see any cases of lobular carcinoma. Men are more likely to have ER and PR positive breast cancer (65-92%).…”

Characterisation of male breast cancer: a descriptive biomarker study from a large patient series

“…Comparative analysis of clinicopathological data from our cohort with combined data extracted from 15 studies published over the last 21 years, reporting ≥30 cases101112141617181932333435363738 was investigated totalling 1984 cases. Key observations from our cohort were that the majority of patients present with ductal histology, grade 2, with high incidence of ER and PR expression, reflective of luminal A phenotype.…”

“…Information derived from these small numbers are at best anecdotal. In the last decade interest in MBC has grown, resulting in accumulation of more substantial numbers of cases allowing study of common biomarkers including estrogen receptor (ER) α, progesterone receptor (PR)910111213) and human epidermal growth factor receptor 2 (HER2)910111213 as well as less frequently evaluated biomarkers such as ERβ9 androgen receptor (AR)910121314), Bcl-21013, p53101213, Ki6710111315, FOXP114, GCDFP14, NAT116, HLA16, MGB14, COX-217, CD3418 and survivin17. BRCA mutations have also been studied19.…”

Clinicopathological characteristics of male breast lesion: An experience in a regional cancer center, Odisha

“…[9] It is usually presents in unilateral, and rarely involves both breasts. [21] In India, It is usually unilateral.…”