Academician G.A. Ilizarov�s scientific heritage: a look into the future from the past (part I) (devoted to 95th anniversary of Academician G.A. Ilizarov, 65th anniversary of the transosseous osteosynthesis method according to Ilizarov)

Professor Gavriil Abramovich Ilizarov was born on June 15, 1921 in the town of Bialowiez in the Bialystok Voivodeship of the Polish Republic. Gavriil was able to go to school only at the age of 11, but his level of education allowed him to pass the exams for the elementary grades, and he was enrolled immediately in the fourth grade. He graduated from the eight-year school with excellent marks and in 1938 continued his studies at the medical faculty in the city of Buinaksk, Dagestan ASSR. In 1939, Gavriil Abramovich entered the Crimean State Medical Institute, after graduating from which in 1944 he worked as a doctor in Polovinskaya and then Kosulinskaya district hospitals of the Kurgan region. At this time, Ilizarov came up with a brilliant idea for the treatment of complex fractures of long tubular bones with the fixation of their fragments with a special metal controlled device instead of blind and static plaster immobilization. In 1955, G. A. Ilizarov was appointed head of the Traumatological and Orthopedic department of the Kurgan Regional Hospital for the Disabled of the Great Patriotic War, where he began to apply his invention. The first official scientific recognition of G. A. Ilizarov received his dissertation «Transosseous compression osteosynthesis by the author’s apparatus (experimental and clinical study)» in September 1968 in Perm. In 1966, on the basis of the 2nd city hospital of Kurgan, the problem laboratory of the Sverdlovsk Research Institute of Traumatology and Orthopedics was organized, the head of which was Gavriil Abramovich, and in 1969 the laboratory was transformed into a branch of the Leningrad Research Institute of Traumatology and Orthopedics named after R. L. Vreden and its director was appointed G. A. Ilizarov. Since 1982, the triumphant introduction of the Ilizarov method into the practice of leading foreign countries began, and the press gave the author the enthusiastic title of «Michelangelo in orthopedics». Gavriil Abramovich successfully engaged in public activities, was elected deputy of the district and regional Councils of Workers‘ Deputies, deputy of the Supreme Soviet of the RSFSR, People’s Deputy of the USSR. For his great achievements in medical science and outstanding services to the national and world health care, G. A. Ilizarov was awarded the highest state awards, academic and honorary titles of the USSR and many foreign countries. Academician Gavriil Abramovich Ilizarov died suddenly of heart failure on July 24, 1992 in Kurgan and was buried in the central alley of the new Riabkovskое cemetery in Kurgan.

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Growth factors of the TGF-b family in blood of achondroplasia patients at stages of orthopedic treatment

Vykhovanets¹,

Сакулин²,

Лунева³

et al. 2018

ZHurnal «Patologicheskaia Fiziologiia I Eksperimental`naia Terapiia»

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Наиболее важной задачей при дистракционном остеосинтезе является создание простых и эффективных способов контроля темпов дистракции позволяющих производить удлинение конечности в оптимальном режиме у различных групп пациентов. Цель исследования - анализ содержания сывороточных концентраций TGFb-1 и TGFb-2, BMP-4 и BMP-6 у лиц при увеличении роста с косметической целью и у пациентов с ахондроплазией на этапах дистракционного остеогенеза при удлинении голени методом Илизарова. Методика. Определение ростовых факторов проводили на комплексе оборудования фирмы Thermofisher (США): детектор Multiscan FC, встряхиватель iEMS, автоматический промыватель планшет WellWash. Для измерения концентрации факторов в сыворотке крови использовали наборы для иммуноферментного анализа (ИФА) eBioscience и RayBiotech Inc. (США). Результаты . Показано, что в сыворотке крови людей с ахондроплазией, еще до какого-либо ортопедического лечения концентрации TGF-b2 и ВМР-4, ниже, а TGF-b1 и ВМР-6, выше, чем концентрации этих факторов у людей при увеличении роста с косметической целью. У последних удлинение конечностей сопровождается возрастанием содержания в сыворотке крови факторов TGF-b1 и TGF-b2 на этапах начала и середины процесса дистракции. У пациентов с ахондроплазией, наблюдается обратная динамика: концентрация данных факторов (ВМР-4 и ВМР-3) в крови ахондропатов к концу дистракции увеличивается в 3,5 и 2 раза соответственно, снижаясь в периоде фиксации. Заключение. Таким образом, у пациентов с ахондроплазией происходит нарушение этапности процессов костного ремоделирования. Elaboration of simple and effective ways for managing the distraction rate to provide an optimum regimen of limb lengthening for different groups of patients is an important task in implementation of transosseous osteosynthesis. The aim of this study was to analyze blood serum concentrations of TGFb-1, TGFb-2, BMP-4, and BMP-6 in individuals undergoing cosmetic height increase and patients with achondroplasia at different stages of distraction osteogenesis in tibial lengthening using the Ilizarov method. Methods. Concentrations of growth factors were measured using a set of Thermofisher (USA) equipment, including a Multiscan FC detector, iEMS Shaker, and automatic WellWash Washer and ELISA kits (eBioscience and RayBiotech Inc., USA). Results. Serum concentrations of TGFb-2 and BMP-4 were lower and TGFb-1 and BMP-6 were higher in achondroplasia patients than in individuals with cosmetic height increase even before any orthopedic treatment. Long bone lengthening for cosmetic height increase was associated with increases in serum levels of TGFb-1 and TGFb-2 at the start and in the middle of distraction. In achondroplasia patients, opposite changes were observed; serum concentrations of BMP-4 and BMP-3 increased 3.5 and 2 times, respectively, by the end of distraction and decreased during fixation. Conclusion. Therefore, we observed a disorder of the stage-by-stage bone remodeling process in achondroplasia patients.

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Academician G.A. Ilizarov�s scientific heritage: a look into the future from the past (part I) (devoted to 95th anniversary of Academician G.A. Ilizarov, 65th anniversary of the transosseous osteosynthesis method according to Ilizarov)

Cited by 3 publications

References 1 publication

Alveolar distraction osteogenesis: possible complications and methods of their treatment

Alveolar distraction osteogenesis: possible complications and methods of their treatment

Academician Gavriil Abramovich Ilizarov (1921–1992) (on the 100th anniversary of the birth)

Growth factors of the TGF-b family in blood of achondroplasia patients at stages of orthopedic treatment

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