Acanthosis nigricans, Papillomatosis mucosae und „tripe palms” bei einem Patienten mit metastasiertem Magenkarzinom

Kleikamp, Stefanie; Böhm, M.; Frosch, P J; Brinkmeier, Thomas

doi:10.1055/s-2006-941753

Cited by 14 publications

(7 citation statements)

References 3 publications

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“…According to other authors (11,18,32), the most common malignancies are adenocarcinomas of the digestive tract and uterus, while carcinomas of the lung, breast, prostate, and ovary are less frequent. Recently, more papers have been published on the association between MAN and gastric adenocarcinoma (18,29,30,33,34), Stomach X-ray, gastroscopy, histopathological examination of the stomach biopsy sample: gastric adenocarcinoma.…”

Section: Laboratory and Other Test Resultsmentioning

confidence: 99%

Malignant Acanthosis Nigricans, Florid Cutaneous Papillomatosis and Tripe Palms Syndrome Associated with Gastric Adenocarcinoma - a Case Report

Paravina

Ljubisavljević

2015

Serbian Journal of Dermatology and Venereology

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Malignant acanthosis nigricans is a rare obligate paraneoplastic dermatosis which accounts for 20% of all acanthosis nigricans cases. The clinical features of the disease are the same as in the benign forms: symmetrical, hyperpigmented, velvety papillomatous lesions mostly involving the axillae, neck, groins, periumbilical cubital and popliteal areas, mammary areolae and less often mucous membranes. However, unlike other forms, it is characterized by sudden onset and rapid spread, commonly (80%) after the age of 40, which may be a marker of malignancy and a key to early diagnosis, indicating the need for a detailed examination. It is a disorder that has no gender differences. Most cases are detected at the moment of cancer diagnosis (61.3%), in fewer cases (about 20%) prior to cancer diagnosis, and in 21% at a later stage of malignant disease. Acanthosis nigricans is usually associated with one of the three or all three forms of paraneoplastic lesions: florid cutaneous papillomatosis, acanthosis palmaris (tripe palms, pachydermatoglyphia) involving the palms and soles, as well as multiple seborrheic keratosis (sign of Leser-Trélat). We report on a female patient with clinically established three paraneoplastic syndromes: malignant acanthosis nigricans, florid cutaneous papillomatosis, and acanthosis palmaris, which appeared before the diagnosis of advanced gastric adenocarcinoma, leading to fatal outcome.

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Section: Laboratory and Other Test Resultsmentioning

confidence: 99%

Malignant Acanthosis Nigricans, Florid Cutaneous Papillomatosis and Tripe Palms Syndrome Associated with Gastric Adenocarcinoma - a Case Report

Paravina

Ljubisavljević

2015

Serbian Journal of Dermatology and Venereology

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“…In our study, compared with the OB group, AN patients showed higher degrees of hyperuricemia. Kleikamp [31] reported that an obese male patient had a history of hyperuricemia with thickening, coarseness and hyperpigmentation in the intertriginous areas of skin. This study showed that in most patients with diabetes, UA levels above normal were due to insulin resistance and hyperinsulinemia [32].…”

Section: Discussionmentioning

confidence: 99%

The Clinical Characteristics of Obese Patients with Acanthosis Nigricans and Its Independent Risk Factors

Huang

Chen

Wang

et al. 2017

Exp Clin Endocrinol Diabetes

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This study aimed to investigate the clinical characteristics and risk factors for acanthosis nigricans (AN) in obese patients. 80 obese patients without AN (OB group) and 128 obese patients with AN (AN group) were included in this study. Clinical data for each patients were collected. Serum levels of leptin were measured by ELISA. Body mass index (BMI), uric acid (UA) levels, fasting insulin, and HOMA-IR were higher in AN than OB (P<0.05). The levels of leptin were significantly higher in AN than OB (P<0.001) after adjustment for BMI and gender. In male patients, AN showed lower serum levels of testosterone than OB (P<0.001). Multiple Logistic-regression analysis demonstrated that UA (OR 4.627, 95%CI 2.443-8.762, P<0.001) and Leptin (OR 4.098, 95%CI 1.237-13.581, P=0.021) were independent risk factors for AN. In addition, low testosterone level was an independent risk factor for AN in male obese patients (OR 39.062, 95%CI 5.523-283.808, P<0.001). AN is associated with more severe hyperinsulinemia and hyperuricemia in obese patients, as well as lower serum testosterone levels in male patients. UA and Leptin were independent risk factors for AN in obese patients. Low testosterone may be a valuable predictor of AN in male obese patients.

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“…Hence, the microscopic examination of a skin biopsy specimen does not allow to differentiate between two variants of the disease [10]. Histopathological findings usually include hyperkeratosis, and papillomatosis with mild hyperpigmentation at the basal layer [11].…”

Section: Discussionmentioning

confidence: 99%

Malignant acanthosis nigricans, florid cutaneous papillo matosis and tripe palms syndrome associated with gastric adenocarcinoma

Stawczyk-Macieja¹,

Szczerkowska-Dobosz²,

Nowicki³

et al. 2014

pdia

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Malignant acanthosis nigricans is a rare paraneoplastic skin syndrome mostly associated with gastric adenocarcinoma. Florid cutaneous papillomatosis and tripe palms syndrome are considered to be abortive clinical variants of acanthosis nigricans. Clinical manifestations include pruritic, hyperkeratotic and hyperpigmented plaques with a subsequent formation of velvety papillomas in the involved areas. This case report describes an unusual case of the patient diagnosed with a combination of malignant acanthosis nigricans, florid cutaneous papillomatosis and tripe palms syndrome associated with gastric adenocarcinoma.

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Acanthosis nigricans, Papillomatosis mucosae und „tripe palms” bei einem Patienten mit metastasiertem Magenkarzinom

Cited by 14 publications

References 3 publications

Malignant Acanthosis Nigricans, Florid Cutaneous Papillomatosis and Tripe Palms Syndrome Associated with Gastric Adenocarcinoma - a Case Report

Malignant Acanthosis Nigricans, Florid Cutaneous Papillomatosis and Tripe Palms Syndrome Associated with Gastric Adenocarcinoma - a Case Report

The Clinical Characteristics of Obese Patients with Acanthosis Nigricans and Its Independent Risk Factors

Malignant acanthosis nigricans, florid cutaneous papillo matosis and tripe palms syndrome associated with gastric adenocarcinoma

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