Ácaros del género Demodex: ¿parásitos colonizadores de personas sanas o asociados a patología ocular?

Mongi, Florencia; Laconte, Laura; Casero, Rodolfo

doi:10.1016/j.ram.2017.09.002

Cited by 8 publications

(9 citation statements)

References 13 publications

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“…However, according to the 18S rRNA sequencing results of one study, the detection rate of Demodex in dander samples scraped from the cheeks of adults over 18 years old was 100% [3]. Many factors may affect ocular surface mite infestation, such as age, diabetes mellitus (DM), dry eye disease (DED), and meibomian gland dysfunction (MGD) [8][9][10][11].…”

Section: Introductionmentioning

confidence: 99%

Demodex Infection Changes Ocular Surface Microbial Communities, in Which Meibomian Gland Dysfunction May Play a Role

Liang

Xiong

et al. 2021

Ophthalmol Ther

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Introduction: Demodex and bacteria are both components of the ocular surface micro-ecology, constituting a complex interaction. This study aims to explore how ocular surface Demodex infestation (DI) affects ocular surface microbial communities and diversity. Methods: We recruited 255 subjects, and examined the correlation between ocular surface mite infestation and clinical indicators such as age, blood glucose level, dry eye symptoms, and blood pressure. 16S rRNA sequencing was performed on the conjunctival swab samples of 14 patients with ocular DI (P group) and 17 healthy people (N group). For further analysis, the subjects were divided into four subgroups, i.e. N-NMGD (n = 11), N-MGD (n = 6), P-NMGD (n = 6), and P-MGD (n = 8), according to meibomian gland dysfunction (MGD) or no MGD (NMGD). Results: There was no difference in the a-diversity of ocular surface microbial communities between the DI and healthy control groups. In linear discriminant analysis effect size (LEfSe), there were more Acinetobacter, Novosphingobium, and Anoxybacillus in the DI group and fewer Novosphingobium, Lactobacillus, and Candidatus Microthrix in the healthy control group. P-NMGD had more Thermaceae and fewer Pseudomonas than P-MGD. There were more Bacteroidetes in N-NMGD than in N-MGD. The Xiaotian Liang and Yingli Li contributed equally to the manuscript.

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Section: Introductionmentioning

confidence: 99%

Demodex Infection Changes Ocular Surface Microbial Communities, in Which Meibomian Gland Dysfunction May Play a Role

Liang

Xiong

et al. 2021

Ophthalmol Ther

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“…Thus, the prevention of OS Demodex infestation plays an important role in ocular surface hygiene. It has been found that multitudinous factors may affect OS Demodex infestation, such as age, diabetes mellitus (DM) [11], dry eye disease (DED) [12], and meibomian gland dysfunction (MGD) [13], etc.…”

Section: Introductionmentioning

confidence: 99%

A Survey on How Ocular Surface Demodex Infestation Interactively Associates with Diabetes Mellitus and Dry Eye Disease

et al. 2021

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Purpose Prevention of ocular surface (OS) Demodex infestation plays an important role in OS hygiene and variety of factors may be associated with it, in which diabetes mellitus (DM) or dry eye disease (DED) has caught the attention of most scholars. However, there has been no research on whether there was a potential interaction between DM and DED in the process of OS Demodex infestation. This cross-sectional study was implemented in Zhujiang Hospital of Southern Medical University. Methods Ophthalmologic interviews, questionnaires, and examinations were conducted. Factors including general information, DM status, dry eye condition, etc. were collected to study the correlation of DM and DED on OS Demodex infestation. Results After statistical analysis, we found that both DM (P < 0.001) and DED (P = 0.013 < 0.05) are closely associated with OS Demodex infestation. Compared with DED, DM has higher priority association with OS Demodex infestation, and patients with both diseases have a significant higher risk of OS Demodex infestation (R = 0.197, P < 0.001). Meanwhile, age (R = 0.299, P < 0.001) and hypertension (P < 0.05) were also correlated with OS Demodex infestation. Conclusion This study provides a new evidence-based basis for clinical prevention and management of OS Demodex infestation.

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“…Kasetsuwan et al reported the prevalence of ocular demodicosis as 70% over the age of 80 [30]. In other studies, it was reported that infestation was signi cantly higher in patients with blepharitis over the age of 50, those over 60 years of age, and those with ocular disease over the age of 70 [31,10,26]. However, in some studies, no signi cant difference was found between increasing age and the presence of mites [22,32].…”

Section: C)mentioning

confidence: 99%

Prevalence of Demodex Folliculorum and Demodex Brevis in Patients with Blepharitis and Chalazion

Akküçük

Kaya

Aslan³

et al. 2021

Preprint

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Purpose: Demodex folliculorum and Demodex brevis are common ectoparasites on skin that also can lead to blepharitis and chalazion. The aim of our study is to determine the prevalence of Demodex spp. in eyelashes of patients diagnosed with chronic blepharitis and chalazion. Methods: This study included 330 patients diagnosed with chronic blepharitis, 70 patients diagnosed with chalazion and 130 volunteers without any ocular problems. Patient eyelashes were examined under a light microscope at magnifications of × 40, × 100 and × 400. Demodex spp. were determined. Results: Parasite prevalence was significantly higher in blepharitis (75.5%) and chalazion groups (70%) compared to the control group (16.2%) (p <0.001). The prevalence of D. folliculorum in the blepharitis group and D. brevis in the chalazion group was found to be significantly higher compared to other groups (p <0.05). The average number of mites per eyelash was found to be significantly higher in patients with Demodex positive blepharitis (p = 0.001) and in chalazion patients (p = 0.047) than in the control group. It has been determined that mite positivity increases with age in blepharitis and control groups (p <0.05). In the group with blepharitis, it was found that mite positivity was significant in the presence of symptoms (p = 0.0001) and Demodex positivity decreased as the education level of individuals increased (p = 0.039). Conclusion: The results of the study show that Demodex acari infestations should be considered in chronic blepharitis and chalazion.

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Ácaros del género Demodex: ¿parásitos colonizadores de personas sanas o asociados a patología ocular?

Cited by 8 publications

References 13 publications

Demodex Infection Changes Ocular Surface Microbial Communities, in Which Meibomian Gland Dysfunction May Play a Role

Demodex Infection Changes Ocular Surface Microbial Communities, in Which Meibomian Gland Dysfunction May Play a Role

A Survey on How Ocular Surface Demodex Infestation Interactively Associates with Diabetes Mellitus and Dry Eye Disease

Prevalence of Demodex Folliculorum and Demodex Brevis in Patients with Blepharitis and Chalazion

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