Accelerated remission of symptoms of acute viral rhinosinusitis with a dry extract of five herbal drugs (BNO 1016)

Jund, R.; Mondigler, Martin; Steindl, Hans; Stammer, Holger; Stierna, Pontus; Bachert, Claus

doi:10.1055/s-0033-1351974

Planta Med

2013

DOI: 10.1055/s-0033-1351974

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Accelerated remission of symptoms of acute viral rhinosinusitis with a dry extract of five herbal drugs (BNO 1016)

R. Jund¹,

Martin Mondigler²,

Hans Steindl³

et al.

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“…[7][8][9][10] These characteristics, as well as the results of two double-blind, placebo-controlled studies recommended the use of Sinupret as a good treatment option in both ARS and chronic rhinosinusitis (CRS). [11,12] The aim of our study was to evaluate the efficacy and safety of combined mometasone furoate nasal spray (MFNS) and oral Sinupret therapy in comparison to MFNS monotherapy when treating mild to moderate ARS. To our knowledge, this is the first such study presented in the literature.…”

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confidence: 99%

Efficacy and safety of combined treatment of acute rhinosinusitis by herbal medicinal product Sinupret and mometasone furoate nasal spray

Perić¹,

Kovačević²,

Gaćeša³

et al. 2017

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Özet: Akut rinosinüzit tedavisinde bitkisel t›bbi ürün Sinupret ile mometazon furoat›n kombine kullan›m›n›n etkinli¤i ve güvenilirli¤iAmaç: Bitkisel t›bbi ürünlerin üst solunum yolu enflamasyonlar›ndaki etkinli¤i bilinmektedir. Güncel bilgilerimiz komplike olmayan akut rinosinüzitte, intranazal kortikosteroidlerin semptomlar› iyilefltirdi¤ini desteklemektedir. Bu çal›flmadaki amac›m›z, hafif ve orta fliddetteki akut rinosinüzitte mometazon furoat sprey ve oral bitkisel ilaç Sinupret'in birlikte kullan›m›n› mometazon furoat sprey monoterapisi ile karfl›lafl-t›rmakt›r.Yöntem: K›rk alt› akut rinosinüzitli hasta iki gruba ayr›ld›. Grup 1 (n=23) günde 3 kez Sinupret, 160 mg oral ve günde 2 kez mometazon furoat sprey 200 μg kulland›. Grup 2 (n=23) ise sadece 7 gün süreyle günde 2 kez mometazon furoat sprey 200 μg kulland›. Çal›flmada tedavi öncesi ve sonras› semptomlar ayr› ayr› (nazal obstrüksiyon, rinore, postnazal ak›nt›, fasiyal a¤r› koku bozuklu¤u), toplam semptom skoru ve endoskopik bulgular (mukoza ödemi ve mukoprülan sekresyon) de¤erlendirildi. Bulgular:Tedavi sonras› her iki tedavi grubundaki tüm klinik parametrelerde düzelme gözlendi (p<0.000). MFNS/Sinupret grubunda MFNS grubundan daha düflük toplam semptom skoru (p=0.002), burun t›kan›kl›¤› (p=0.001), burun ak›nt›s› (p=0.001), yüz a¤r›s› (p=0.001), koku bozuklu¤u (p=0.002), mukozal ödem (p=0.003) ve mukopürulan ak›nt› (p=0.001) oldu¤u gözlemlendi. MFNS/Sinupret grubunda hiç bir yan etki görülmezken, sadece MFNS grubunda 1 hastada hafif epistaksis ve 1 burun kurulu¤u gözlendi.Sonuç: Sonuçlar›m›z akut rinosinüzitte MFNS/Sinupret kombine tedavisinin semptomlar ve endoskopik bulgular üzerinde daha etkili oldu¤unu göstermifltir. MFNS monoterapisine k›yasla hiçbir advers olay bildirilmemifltir.Anahtar sözcükler: Glukokortikoidler, inflamasyon, t›bbi bitki, rinit, sinüzit. AbstractObjective: Herbal medicinal products have a well-established role in therapy of upper airway inflammations. Current evidence supports the use of intranasal corticosteroids for improvement in clinical symptoms of uncomplicated acute rhinosinusitis (ARS). We aimed to evaluate efficacy and safety of combined therapy by mometasone furoate nasal spray (MFNS) and oral herbal medicinal product Sinupret in comparison to MFNS monotherapy when treating mild to moderate ARS. Methods:Forty-six ARS patients were divided into two groups. Group 1 (n=23) received herbal drug Sinupret, 160 mg per os, three times daily and MFNS 200 μg twice daily for 7 days. Group 2 (n=23) received only MFNS 200 μg twice daily for 7 days. We assessed total symptom score (TSS), individual symptom scores for each symptom (nasal obstruction, rhinorrhea, postnasal drip, facial pain/pressure, impaired sense of smell) and endoscopic findings (mucosal edema, mucopurulent secretion), before and after treatment.Results: Significant improvement of all clinical parameters was found after both treatment modalities (p<0.000). We observed lower post-treatment TSS (p=0.002), nasal obstruction (p=0.001), rhinorrhea (p=0.001), facial pai...

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confidence: 99%

Efficacy and safety of combined treatment of acute rhinosinusitis by herbal medicinal product Sinupret and mometasone furoate nasal spray

Perić¹,

Kovačević²,

Gaćeša³

et al. 2017

ENT Updates

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Accelerated remission of symptoms of acute viral rhinosinusitis with a dry extract of five herbal drugs (BNO 1016)

Cited by 1 publication

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Efficacy and safety of combined treatment of acute rhinosinusitis by herbal medicinal product Sinupret and mometasone furoate nasal spray

Efficacy and safety of combined treatment of acute rhinosinusitis by herbal medicinal product Sinupret and mometasone furoate nasal spray

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