Accelerating Bone Healing by Decorating BMP-2 on Porous Composite Scaffolds

Li, Xiang; Yin, Hua-Mo; Luo, En; Wang, Peng; Zhang, Zhen; Liao, Guiqing; Xu, Jia‐Zhuang; Li, Zhong‐Ming; Li, Jihua

doi:10.1021/acsabm.9b00761

Cited by 14 publications

(8 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Both PDT and PDTC can promote cell proliferation (Figure 1g ). The effects of the films on the expression of functional factors regarding angiogenesis/osteogenesis associated (e.g., VEGF (an important angiogenic index [ 46 ] ) and BMP‐2 (an important osteogenic factor [ 47 ] ) expression, Col I (extracellular matrix of bone [ 48 ] ) secretion) were detected via immunofluorescence (IF) staining and ELISA. As shown in Figure 1h and Figure S8 , Supporting Information, cells cultured on the PDTC film showed the highest expression and secretion of VEGF, BMP‐2, and Col I.…”

Section: Resultsmentioning

confidence: 99%

Bioactive Film‐Guided Soft–Hard Interface Design Technology for Multi‐Tissue Integrative Regeneration

Chen

Jiang

et al. 2022

Advanced Science

View full text Add to dashboard Cite

Control over soft-to-hard tissue interfaces is attracting intensive worldwide research efforts. Herein, a bioactive film-guided soft-hard interface design (SHID) for multi-tissue integrative regeneration is shown. Briefly, a soft bioactive film with good elasticity matchable to native ligament tissue, is incorporated with bone-mimic components (calcium phosphate cement, CPC) to partially endow the soft-film with hard-tissue mimicking feature. The hybrid film is elegantly compounded with a clinical artificial ligament to act as a buffer zone to bridge the soft (ligament) and hard tissues (bone). Moreover, the bioactive film-decorated ligament can be rolled into a 3D bio-instructive implant with spatial-controllable distribution of CPC bioactive motifs. CPC then promotes the recruitment and differentiation of endogenous cells in to the implant inside part, which enables a vascularized bone growth into the implant, and forms a structure mimicking the biological ligament-bone interface, thereby significantly improving osteointegration and biomechanical property. Thus, this special design provides an effective SHID-guided implant-bioactivation strategy unreached by the traditional manufacturing methods, enlightening a promising technology to develop an ideal SHID for translational use in the future.

show abstract

Section: Resultsmentioning

confidence: 99%

Bioactive Film‐Guided Soft–Hard Interface Design Technology for Multi‐Tissue Integrative Regeneration

Chen

Jiang

et al. 2022

Advanced Science

View full text Add to dashboard Cite

show abstract

“…Inspired by mussels, the catechol group in polydopamine forms a covalent binding with BMP-2, which enhances the connectivity between them and can reduce the initial burst release of BMP-2. Li et al used polydopamine to immobilize BMP-2 on the polymer scaffold (PHB-PDA-BMP-2) [ 88 ]. BMP-2 in the PHB-PDA-BMP-2 scaffold sustained release for up to 30 days without an initial burst.…”

Section: Bioactive Factors-loaded N-hap Composite Scaffoldsmentioning

confidence: 99%

Nano-Hydroxyapatite Composite Scaffolds Loaded with Bioactive Factors and Drugs for Bone Tissue Engineering

Zhang

Liu

et al. 2023

IJMS

View full text Add to dashboard Cite

Nano-hydroxyapatite (n-HAp) is similar to human bone mineral in structure and biochemistry and is, therefore, widely used as bone biomaterial and a drug carrier. Further, n-HAp composite scaffolds have a great potential role in bone regeneration. Loading bioactive factors and drugs onto n-HAp composites has emerged as a promising strategy for bone defect repair in bone tissue engineering. With local delivery of bioactive agents and drugs, biological materials may be provided with the biological activity they lack to improve bone regeneration. This review summarizes classification of n-HAp composites, application of n-HAp composite scaffolds loaded with bioactive factors and drugs in bone tissue engineering and the drug loading methods of n-HAp composite scaffolds, and the research direction of n-HAp composite scaffolds in the future is prospected.

show abstract

“…rhBMP-2 is mainly used for osteoinduction in the oral and maxillofacial region [ 16 , 17 ]. It induces bone regeneration when applied to bone graft materials [ 18 , 19 , 20 ]. The carrier increases the osteogenesis-inducing and regenerative abilities of rhBMP-2, and its regeneration potential depends on the carrier system [ 21 , 22 , 23 ].…”

Section: Introductionmentioning

confidence: 99%

Improving Bone Formation by Guided Bone Regeneration Using a Collagen Membrane with rhBMP-2: A Novel Concept

Jung

Park

et al. 2023

JFB

View full text Add to dashboard Cite

We examined whether recombinant human bone morphogenetic protein-2 (rhBMP-2) when applied to collagen membranes, would reinforce them during guided bone regeneration. Four critical cranial bone defects were created and treated in 30 New Zealand white rabbits, including a control group, critical defect only; group 1, collagen membrane only; group 2, biphasic calcium phosphate (BCP) only; group 3, collagen membrane + BCP; group 4, collagen membrane with rhBMP-2 (1.0 mg/mL); group 5, collagen membrane with rhBMP-2 (0.5 mg/mL); group 6, collagen membrane with rhBMP-2 (1.0 mg/mL) + BCP; and group 7, collagen membrane with rhBMP-2 (0.5 mg/mL) + BCP. After a 2-, 4-, or 8-week healing period, the animals were sacrificed. The combination of collagen membranes with rhBMP-2 and BCP yielded significantly higher bone formation rates compared to the other groups (control group and groups 1–5 < groups 6 and 7; p < 0.05). A 2-week healing period yielded significantly lower bone formation than that at 4 and 8 weeks (2 < 4 = 8 weeks; p < 0.05). This study proposes a novel GBR concept in which rhBMP-2 is applied to collagen membranes outside instead of inside the grafted area, thereby inducing quantitatively and qualitatively enhanced bone regeneration in critical bone defects.

show abstract

Accelerating Bone Healing by Decorating BMP-2 on Porous Composite Scaffolds

Cited by 14 publications

References 44 publications

Bioactive Film‐Guided Soft–Hard Interface Design Technology for Multi‐Tissue Integrative Regeneration

Bioactive Film‐Guided Soft–Hard Interface Design Technology for Multi‐Tissue Integrative Regeneration

Nano-Hydroxyapatite Composite Scaffolds Loaded with Bioactive Factors and Drugs for Bone Tissue Engineering

Improving Bone Formation by Guided Bone Regeneration Using a Collagen Membrane with rhBMP-2: A Novel Concept

Contact Info

Product

Resources

About