Accidental Caustic Ingestion in Children: Is Endoscopy Always Mandatory?

Lamireau, T.; Rebouissoux, Laurent; Denis, Delphine; Lancelin, F.; Vergnes, P; Fayon, Michaël

doi:10.1097/00005176-200107000-00014

Cited by 99 publications

(65 citation statements)

References 25 publications

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“…It has been proposed to be unnecessary in asymptomatic patients as the injury then is most likely low-grade. [12][13][14] Although these cases require monitoring, intervention can usually be avoided. 15 However, it is well documented that patients without evidence of buccal or pharyngeal injury can have significant oesophagal mucosal injury.…”

Section: Discussionmentioning

confidence: 99%

Cost-Effectiveness of the Sucralfate Technetium 99m isotope Labelled Esophageal Scan to Assessesophageal Injury in Children after Caustic Ingestion

Janssen¹,

Dijk²,

et al. 2015

Emerg Med Open J

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Section: Discussionmentioning

confidence: 99%

Cost-Effectiveness of the Sucralfate Technetium 99m isotope Labelled Esophageal Scan to Assessesophageal Injury in Children after Caustic Ingestion

Janssen¹,

Dijk²,

et al. 2015

Emerg Med Open J

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“…The extent and depth of injury depends on the quantity, concentration, and pH of the causative substance, as well as tissue contact time. 1,7,16 Determining the presence and extent and depth of the injury is critical for predicting the risk of late complications of corrosive ingestion. While clinical findings may provide information concerning esophageal and gastric injury, several studies report that clinical signs and symptoms are not always helpful in predicting the degree of injury and subsequent stricture formation.…”

Section: Figure 2: a Bmentioning

confidence: 99%

“…While clinical findings may provide information concerning esophageal and gastric injury, several studies report that clinical signs and symptoms are not always helpful in predicting the degree of injury and subsequent stricture formation. 16,17 Endoscopy, which is usually performed under anesthesia, remains the best method for evaluating the depth and extent of injury. The present study induced different degrees of esophagitis in rats using different concentrations of NaOH, to investigate if injury and late complications could be predicted based on biochemical analysis, which is less invasive and easier to perform than endoscopy.…”

Section: Figure 2: a Bmentioning

confidence: 99%

Late Complications of Corrosive Esophagitis May Be Predicted Using Biochemical Methods: Preliminary Report

Temız¹,

Unal²,

Koçer³

et al. 2012

Turkiye Klinikleri J Med Sci

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A AB BS ST TR RA AC CT T O Ob bj je ec ct ti iv ve e: : High tissue levels of free oxygen radicals (FORs) have been reported in corrosive esophagitis (CE). The present study aimed to determine whether prediction of injury and late complications in CE is possible based on blood levels of FORs, Interleukin (IL)-6, Tumor necrosis factor (TNF)-α, and IL-10. M Ma at te er ri ia al l a an nd d M Me et th ho od ds s: : Forty-two male Wistar albino rats were randomly divided into 2 main groups (A and B), each consisting of 3 subgroups (A1, A2, A3, B1, B2, and B3) of equal number. To induce experimental CE 17.5% NaOH was used in subgroups A2 and B2, and 37.5% NaOH in subgroups A3 and B3. The sham groups (A1 and B1) received 0.9% NaCl. Blood levels of lipid hydroperoxide (LPO) and glutathione peroxidase (GPx) were measured in group A. Blood levels of IL-6, IL-10, and TNF-α were measured in group B. Esophageal samples for histopathological evaluation were obtained following scarification after 3 weeks. R Re es su ul lt ts s: : There were significant differences between the sham subgroups and CE subgroups, regarding histopathological scores (p< 0.05). There was no significant difference between the groups in blood levels of LPO, GPX, TNF-α or IL-10 (p> 0.05). There were significant differences between severe CE subgroups and the sham subgroups, based on IL-6 values (p= 0,007). C Co on nc cl lu us si io on n: : In contrast to previous reports, which demonstrated increased tissue levels of FORs, blood levels of FORs were not high in this study. Nonetheless, in the light of the observed differences in IL-6 levels between the subgroups, we suggest that injury and late complications of CE may be predicted following additional experimental and clinical research using biochemical methods.K Ke ey y W Wo or rd ds s: : Caustics; esophagitis; complications; cytokines Ö ÖZ ZE ET T A Am ma aç ç: : Koroziv özofajitte, yaralanmanın ve geç komplikasyonların öngörülmesinde çeşitli yöntem-ler bildirilmiştir. Yapılan çalışmalar, akut dönemde, dokudaki serbest oksijen radikalleri (SOR) düzeyleri-nin artmış olduğunu ortaya koymuştur. Çeşitli travmalarda interlökin (IL)-6, tümör nekroz faktörü (TNF)-α ve IL-10 gibi proenflamatuar sitokin (PES) ve anti-enflamatuar sitokin (AES) düzeylerinde değişiklikler olduğu bilinmektedir. Bu bilgiler ışığında koroziv özofajit modelinde SOR, PES ve AES'lerin kan düzeyleri-nin, doku hasarının ve striktür gelişiminin öngörülmesinde etkili olup olamayacağının araştırılması amaçlanmıştır. G Ge er re eç ç v ve e Y Yö ön nt te em ml le er r: : Çalışmada 42 erkek Wistar Albino sıçan kullanıldı. Sıçanlar, A ve B grupları şeklinde iki ana gruba ayrıldıktan sonra, bu iki ana grup da her birinde eşit sayıda sıçan olacak şekilde üçer alt gruba ayrıldı (A1, A2, A3, B1, B2 ve B3). A2 (n= 7) ve B2 (n= 7) gruplarında %17,5'luk sodyum hidroksit (NaOH), A3 (n= 7) ve B3 (n= 7) gruplarında ise %37,5'luk NaOH kullanılarak özofajit oluşturuldu. Kontrol gruplarını oluşturan A1 (n= 7) ve B1 (n= 7) gruplarında izotonik kullanıldı. A g...

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“…Cependant, plusieurs auteurs [9][10][11] ont proposé, chez l'enfant, de ne réaliser une endoscopie digestive que lorsqu'il existe des signes cliniques, soit mineurs (lésions orales ou oropharyngées, vomissements), soit majeurs (dyspnée, dysphagie, hypersialorrhée, hématémèse). En effet, en analyse multivariée, la présence de symptômes cliniques est le seul facteur prédictif de lésions sévères de l'oesophage [11].…”

Section: Classification Endoscopique Des Lésionsunclassified

Consensus en endoscopie digestive : prise en charge des œsophagites caustiques

et al. 2011

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Recommandations de la sFed / SFED RECOMMENDATIONSConsensus en endoscopie digestive : prise en charge des oesophagites caustiques Consensus in digestive endoscopy: treating caustic oesophagitis Chargé de projet : Alain Lachaux Groupe de travail : Emmanuel Mas, Anne Breton, Karl Barange Groupe de lecture : Denis Heresbach, Bruno Richard Molard et la commission recommandation de la SFED © Springer-Verlag France 2011 e. mas · a. Breton

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Accidental Caustic Ingestion in Children: Is Endoscopy Always Mandatory?

Abstract: In conclusion, endoscopy is not recommended for children living in developed countries who are asymptomatic after accidental caustic ingestion.

Cited by 99 publications

References 25 publications

Cost-Effectiveness of the Sucralfate Technetium 99m isotope Labelled Esophageal Scan to Assessesophageal Injury in Children after Caustic Ingestion

Cost-Effectiveness of the Sucralfate Technetium 99m isotope Labelled Esophageal Scan to Assessesophageal Injury in Children after Caustic Ingestion

Late Complications of Corrosive Esophagitis May Be Predicted Using Biochemical Methods: Preliminary Report

Consensus en endoscopie digestive : prise en charge des œsophagites caustiques

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