In the article researches mathematical models that ensure effectiveness of use combined methods for parts processing. The use of combined processing methods is always associated with the search for technological compromise and boils down to technical and economic indicators comparative assessment. In this case, it is necessary to rely on mathematical models that objectively reflect manufacturing parts technological processes. Mathematical methods and models for optimizing production processes for manufacturing parts that are applicable in combined methods for processing parts are a complex formalized scientific abstraction that describes production functioning process at all stages of its implementation. In the synthesis of various processing methods, it is necessary to ensure that a number of conditions are met that determine necessary and sufficient conditions for implementing feasibility a particular technology in the combined method of processing parts. Multiple regression analysis methods allow minimizing experiments number in mathematical model determining which adequate to processes under study and form the baseline data for the transition from multi-factor to multi-criteria models. Using this approach, it is necessary to determine objective function optimal values parameters and influence factors in each specific technological process, which will allow us to bring the uncertainty removal in the processing materials technology to a new qualitative level.