Accumulation, distribution and toxicology of dietary nickel in lake whitefish (Coregonus clupeaformis) and lake trout (Salvelinus namaycush)

Ptashynski, M.D; Pedlar, R.M; Evans, R. E.; Wautier, Kerry; Baron, Christopher L.; Klaverkamp, J. F.

doi:10.1016/s1532-0456(01)00228-9

Cited by 25 publications

(9 citation statements)

References 32 publications

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“…In studies on the histopathological effects of pollution on fish liver tissue, altered staining, focal necrosis, hepatocytes with pyknotic nucleus, and altered hepatic cord have been reported [3,61]. Furthermore, hepatocellular necrosis, increases in fat vacuolization, sinusoids, and venules filled with red blood cells were observed occasionally in coppertreated specimens of liver [25].…”

Section: Discussionmentioning

confidence: 99%

Genotoxic and Histopathological Effects of Water Pollution on Two Fish Species, Barbus capito pectoralis and Chondrostoma nasus in the Büyük Menderes River, Turkey

Koca

Yıldız

et al. 2008

Biol Trace Elem Res

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The genotoxic and histopathological effects of water pollution were investigated on two fish species caught from the Buyuk Menderes River and from its tributary, the Cine Stream. The Buyuk Menderes basin is an important agricultural area in Turkey. The levels of copper, zinc, cadmium, cobalt, and lead were measured at the surface of the water and in gills, liver, and muscle tissue of Chondrostoma nasus and Barbus capito pectoralis. In some tissues, the concentrations of some of these metals exceeded acceptable levels for human consumption. Zinc was found to be the most abundant metal in water and tissues. Maximal metal accumulation was observed in the liver. To detect the genotoxic potential of contaminants, the formation of micronucleus in erythrocytes was used as indicator of chromosomal damage. The frequency of micronucleus formation did not show significant differences between locations and controls in B. capito pectoralis caught from three locations and C. nasus from two locations. The histological changes included significant decreases of the mean lengths of primary and secondary lamellae. In gills epithelia, we observed cellular proliferation that developed Because of secondary lamellae fusion, ballooning degenerations, or club deformation of secondary lamellae and cystic structures in secondary lamellae. In the liver, the changes included swollen and ruptured parenchymal cells, loss of cord structure, vacuoles filled with cellular debris, focal necrosis, and a significant increase in Kupffer cells.

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Section: Discussionmentioning

confidence: 99%

Genotoxic and Histopathological Effects of Water Pollution on Two Fish Species, Barbus capito pectoralis and Chondrostoma nasus in the Büyük Menderes River, Turkey

Koca

Yıldız

et al. 2008

Biol Trace Elem Res

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“…However, Ni is toxic at elevated concentrations, with its compounds being nephrotoxic, hepatotoxic, immunotoxic, and teratogenic (Mas et al 1985;Misra et al 1991;Vyskocil et al 1994;Pari and Prasath 2008;Vijayavel et al 2009), with respect that Ni has known multisystem impacts on human health following its exposure, and major target organs include liver, kidney, brain, lung, and testes (Pari and Prasath 2008). Actually, Ni has been classified as a human carcinogen on the basis of epidemiological studies showing a higher incidence of nasal and lung cancers in occupationally exposed workers (Coogan et al 1989;Haber et al 2000 Ni can generate reactive oxygen species (ROS) (Prophete et al 2006;Gopal et al 2009;Vijayavel et al 2009), leading to an increase in lipid peroxidation (LPO) (Ptashynski et al 2001(Ptashynski et al , 2002, a loss of membrane integrity (Ptashynski et al 2002), and alterations of the cellular antioxidant system (Gopal et al 2009). Depletion in reduced glutathione (GSH) (Sidhu et al 2004) and changes of antioxidant enzymes [e.g., superoxide dismutase (SOD), glutathione peroxidase (GPx), and glutathione-S-transferase (GST)] activities are also observed after exposure to Ni (Misra et al 1990;Chakrabarti and Bai 1999;Hfaiedh et al 2008).…”

Section: Introductionmentioning

confidence: 99%

Oxidative damage effects in the copepod Tigriopus japonicus Mori experimentally exposed to nickel

Wang

2009

Ecotoxicology

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Tigriopus japonicus Mori has been recognized as a good model for toxicological testing of marine pollutants. Recently, a large number of genes have been identified from this copepod, and their mRNA expression has been studied independently against exposure to marine pollutants; however, biochemical-response information is relatively scarce. The response of T. japonicus to nickel (Ni) additions was examined under laboratory-controlled conditions in 12 days exposure. Superoxide dismutase (SOD), glutathione peroxidase (GPx), glutathione-S-transferase (GST), acetylcholinesterase (AchE), reduced glutathione (GSH), the ratio of reduced to oxidized glutathione (GSH/GSSG) and metallothionein (MT) were analyzed for Ni treatments (0, 0.125, 0.25, 0.75 and 3.0 mg/L) after 1, 4, 7 and 12 days. The thiobarbituric reactive species assay was used to evaluate lipid peroxidation (LPO) level in copepods after exposure. The results showed that Ni remarkably affected the biochemical parameters (SOD, GPx, GST, GSH, and GSH/GSSG) after certain exposure durations. However, the copepod's LPO level was significantly decreased under metal treatments after exposure, hinting that the factors involved in LPO might not significantly depend on the operations and functions in the antioxidant system. Ni exhibited the neurotoxicity to copepods, because its use obviously elevated AchE activity. During exposure, Ni initially displayed an inhibition effect but induced MT synthesis in T. japonicus by day 12, probably being responsible for metal detoxification. Thus, Ni had intervened in the detoxification process and antioxidant system of this copepod, and it could be used as a suitable bioindicator of Ni exposure via measuring SOD, GPx, GST, and MT as biomarkers.

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“…An 18-day experiment was conducted by Ptashynski et al (2001) to investigate the uptake of dietary Ni administered in the form of NiSO 4 in adult lake whitefish (LWF) and lake trout (LT) fed diets containing 0, 1000 and 10 000 mg Ni/kg, prepared with and without brine shrimp. Increased Ni concentrations in all LWF tissues, except the intestine, were associated with increased doses of Ni.…”

Section: Fishmentioning

confidence: 99%

Scientific Opinion on the risks to animal and public health and the environment related to the presence of nickel in feed

Publication¹

2015

EFS2

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Following a request from the European Commission, the risks to animal and human health and the environment related to the presence of nickel (Ni) in feed were assessed by the EFSA Panel on Contaminants in the Food Chain (CONTAM Panel). The presence of Ni in feed can arise from both natural and anthropogenic sources. Additionally, certain feed materials contain metallic Ni, since it is used as a catalyst in their production. Based on the differences observed between the Ni exposure levels estimated for different animal species and identified no observed adverse effect levels (NOAELs) and lowest observed adverse effect levels (LOAELs), the CONTAM Panel concluded that any adverse impact of Ni via feed to cattle, pigs, rabbits, ducks, fish, dogs, chickens, horses, sheep, goats and cats is unlikely. Concerning the assessment of human health risks from the presence of Ni in food of animal origin, the CONTAM Panel concluded that in the average population the current levels of chronic exposure to Ni, considering only foods of animal origin, might be of potential concern in the young population, in particular in 'Toddlers'. In the highly exposed population (95th percentile), the concern also extends to the age class 'Other children'. Regarding acute dietary exposure, the CONTAM Panel concluded that Ni-sensitized individuals are also at risk of developing eczematous flare-up skin reactions through the consumption of food of animal origin. The contribution of food of animal origin to human dietary exposure to Ni should therefore not be underestimated, particularly in age classes with high dietary exposure to Ni. Release to the environment from manure, resulting from its presence in animal feed, is not a major contributor of Ni deposited onto agricultural soils or to the environment. SUMMARYFollowing a request from the European Commission, the risks to animal and human health and the environment related to the presence of nickel (Ni) in feed were assessed by the EFSA Panel on Contaminants in the Food Chain (CONTAM Panel).Ni is a metal that occurs in a number of different soluble and particulate forms, which are ubiquitously found in the environment both from natural occurrence and from anthropogenic activity. Animal feed contains Ni, particularly in the divalent form, its most stable oxidation state. Additionally certain vegetable oils can contain traces of metallic Ni, since it is used as a catalyst in their hydrogenation.Following a call for data, two European countries, submitted 1 813 results on Ni concentrations in feed of which 1 794 were from one country. All results were reported as total Ni, with no differentiation between Ni species. Feed related exposure to Ni was estimated by applying two different scenarios, namely (i) exposures based on Ni concentrations in compound feed and forages and (ii) exposures derived from Ni in feed materials including hydrogenated vegetable oils. For compound feed, 317 results were provided, though the livestock species for which these feeds had been manufactured were not gi...

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Accumulation, distribution and toxicology of dietary nickel in lake whitefish (Coregonus clupeaformis) and lake trout (Salvelinus namaycush)

Cited by 25 publications

References 32 publications

Genotoxic and Histopathological Effects of Water Pollution on Two Fish Species, Barbus capito pectoralis and Chondrostoma nasus in the Büyük Menderes River, Turkey

Genotoxic and Histopathological Effects of Water Pollution on Two Fish Species, Barbus capito pectoralis and Chondrostoma nasus in the Büyük Menderes River, Turkey

Oxidative damage effects in the copepod Tigriopus japonicus Mori experimentally exposed to nickel

Scientific Opinion on the risks to animal and public health and the environment related to the presence of nickel in feed

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