Accuracy of Capillary Hemoglobin Measurements for the Detection of Anemia among U.S. Low-Income Toddlers and Pregnant Women

Boghani, Safia; Mei, Zuguo; Perry, Geraldine S.; Brittenham, Gary M.; Cogswell, Mary E.

doi:10.3390/nu9030253

Cited by 26 publications

(37 citation statements)

References 26 publications

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“…In a study among low-income young children and PW in the United States that had all comparisons falling within the ±7% mean concentration bias threshold, Boghani et al reported sensitivity and specificity for the different data collection sites and included various analyses examining either capillary or venous blood analyzed on HemoCue models compared with venous blood analyzed on a Coulter Counter as the reference. 8 The sensitivities reported for all comparisons for young children ranged from 32.8% to 60.4% and the specificities from 85.6% to 97.7%. For PW, sensitivities were 66.7% and 92.6%; and specificities were 98.1% and 96.7%, respectively.…”

Section: Discussionmentioning

confidence: 91%

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Methods and analyzers for hemoglobin measurement in clinical laboratories and field settings

Whitehead

Mei

Mapango

et al. 2019

Annals of the New York Academy of Sciences

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This paper describes and compares methods and analyzers used to measure hemoglobin (Hb) in clinical laboratories and field settings. We conducted a literature review for methods used to measure Hb in clinical laboratories and field settings. We described methods to measure Hb and factors influencing results. Automated hematology analyzer (AHA) was reference for all Hb comparisons using evaluation criteria of ±7% set by College of American Pathologists (CAP) and Clinical Laboratory Improvement Amendments (CLIA). Capillary fingerprick blood usually produces higher Hb concentrations compared with venous blood. Individual drops produced lower concentrations than pooled capillary blood. Compared with the AHA: (1) overall cyanmethemoglobin (1.0–8.0 g/L), WHO Colour Scale (0.5–10.0 g/L), paper-based devices (5.0–7.0 g/L), HemoCue® Hb-201 (1.0–16.0 g/L) and Hb-301 (0.5–6.0 g/L), and Masimo Pronto® (0.3–14.0 g/L) overestimated concentrations; (2) Masimo Radical® −7 both under- and overestimated concentrations (0.3–104.0 g/L); and (3) other methods underestimated concentrations (2.0–16.0 g/L). Most mean concentration comparisons varied less than ±7% of the reference. Hb measurements are influenced by several analytical factors. With few exceptions, mean concentration bias was within ±7%, suggesting acceptable performance. Appropriate, high-quality methods in all settings are necessary to ensure the accuracy of Hb measurements.This paper describes and compares methods and analyzers used to measure hemoglobin (Hb) in clinical laboratories and field settings. With few exceptions, mean concentration bias was within ±7%, suggesting acceptable performance. Appropriate, high-quality methods in all settings are necessary to ensure the accuracy of Hb measurements.

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Section: Discussionmentioning

confidence: 91%

“…8–11 Clinical laboratories are controlled environments. Field settings include areas in the natural environment outside of a controlled environment.…”

Section: Introductionmentioning

confidence: 99%

Methods and analyzers for hemoglobin measurement in clinical laboratories and field settings

Whitehead

Mei

Mapango

et al. 2019

Annals of the New York Academy of Sciences

Self Cite

123

100

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“…Point‐of‐care testing devices measuring only Hb are sometimes useful, especially for large‐scale screening, but CBC (including Ht, MCV, and RDW) should be performed because low MCV and elevated RDW further support the diagnosis of IDA. Several reports have shown there is a lower quality of measurement by capillary blood sampling . If blood is collected according to the procedure, however, the same quality compared with venous blood sampling is guaranteed.…”

Section: Discussionmentioning

confidence: 99%

“…Several reports have shown there is a lower quality of measurement by capillary blood sampling. 49,50 If blood is collected according to the procedure, however, the same quality compared with venous blood sampling is guaranteed. We previously reported the possibility of using non-invasive Hb measuring devices for screening for children's anemia.…”

Section: Methods Of Screening For Infant Anemiamentioning

confidence: 99%

Prevalence of infant and maternal anemia during the lactation period in Japan

Amano

Murakami

2019

Pediatrics International

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Background The perinatal period is associated with a high risk of infant anemia. The aim of the present study was to determine the prevalence of infant and maternal anemia during the late lactation period and the risk factors for anemia in Japan. Methods This retrospective cohort study was based on data from health checkups of healthy infants at 6–7 and 9–10 months of age and their mothers who visited Akitsu Children's Clinic between September 2013 and August 2015. Complete blood count data from infant blood samples obtained at 6–7 months and 9–10 months and from maternal blood samples obtained at 6–7 months, information on feeding methods, and other related parameters were analyzed. Results Data from 388 mother–infant pairs were analyzed. The prevalence of infant anemia was 21.1% at 6–7 months and 29.1% at 9–10 months. The prevalence of anemia in exclusively breast‐fed infants was 28.4% at 6–7 months and 40.0% at 9–10 months. The risk factors for infant anemia at 9–10 months were exclusive breast‐feeding, lower gestational age at birth, male sex, and high weight gain. The prevalence of maternal anemia was 10.5%. There was no correlation between infant and maternal hemoglobin in exclusively breast‐fed infants. Conclusions Japanese infants who were breast‐fed exclusively had a high prevalence of anemia. A nationwide strategy to prevent anemia is required to prevent infant anemia, even in a nutrition‐rich country such as Japan.

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“…Under medical supervision, 0.5ml of venous blood sample was drawn from these babies by a qualified personnel after obtaining informed consent from their parents. [12][13][14] Blood collected in sterile vacuum tubes with EDTA was analyzed for hemoglobin concentration using autoanalyzer.…”

Section: Methodsmentioning

confidence: 99%

Risk of infant anemia in 3-6 months old babies and its association with maternal anemia

J¹,

Monisha²

2018

Int J Contemp Pediatr

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Background: Anemia is a significant health problem in developing countries. Maternal anemia reduces fetal iron stores prior to birth and hence babies born to anemic mothers tend to develop iron deficiency anemia before 6 months which has adverse psychomotor consequences. Objective of this study was to estimate the prevalence of anemia and weight gain pattern in 3 - 6 months old term exclusively breast-fed infants and its association with maternal anemia.Methods: This is a cross - sectional analytical study including 120 babies who are born as term appropriate for gestational age. Preterm and babies with history of bleed or jaundice were excluded from the study. The haemoglobin estimation and weights of these babies was measured after informed consent from parents. Maternal haemoglobin concentration during last trimester was obtained from the maternal records.Results: Seventy-nine (65.8%) out of 120 babies had haemoglobin concentration <11gm/dl, which was significantly associated with maternal anemia (p <0.004, OR 5.9). Thirty-seven (30.8%) babies had low weight for age and were born to anemic mothers and 28% of this variation in weight was contributed by maternal anemia (p = 0.001).Conclusions: Low haemoglobin and poor weight gain in term 3-6 months old babies are significantly associated with maternal anemia in last trimester.

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Accuracy of Capillary Hemoglobin Measurements for the Detection of Anemia among U.S. Low-Income Toddlers and Pregnant Women

Cited by 26 publications

References 26 publications

Methods and analyzers for hemoglobin measurement in clinical laboratories and field settings

Methods and analyzers for hemoglobin measurement in clinical laboratories and field settings

Prevalence of infant and maternal anemia during the lactation period in Japan

Risk of infant anemia in 3-6 months old babies and its association with maternal anemia

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