Accuracy of oxygen saturation index in determining the severity of respiratory failure among preterm infants with respiratory distress syndrome

Khalesi, Nasrin; Choobdar, Farhad Abolhasan; Khorasani, Mousa; Sarvi, Fatemeh; Aski, Behzad Haghighi; Khodadost, Mahmoud

doi:10.1080/14767058.2019.1666363

Cited by 20 publications

(18 citation statements)

References 15 publications

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“…OSI has been consistently shown to be useful even in neonates where the oxygen dissociation curve is significantly influenced by higher quantity of fetal hemoglobin. 9 10 11 17 This support the use of OSI in children where such issue is less significant.…”

Section: Discussionmentioning

confidence: 59%

Can Noninvasive Oxygen Saturation Index Match Invasive Oxygenation Index to Monitor Respiratory Disease in Critically Ill Children?—A Prospective Study

Chowdary

Doreswamy

2022

J Pediatr Intensive Care

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Respiratory illnesses are common indications for mechanical ventilation in children. The adequacy of ventilatory support for oxygenation is measured using arterial blood gas analysis and calculation of oxygenation index (OI). Due to invasive nature of arterial blood sampling needed to calculate OI, several researchers have replaced blood gas-derived partial pressure of oxygen values with oxygen saturation (SpO2) obtained from pulse oximetry. This noninvasive index called oxygen saturation index (OSI) is found to be useful in neonates. Studies in pediatric population is lacking. In this prospective study on mechanically ventilated children, both OI and OSI were determined and compared against alveolar–arterial oxygen difference (AaDO2). A total of 29 children were studied. Both OSI and OI had good correlation of 0.787 and 0.792 with AaDO2, respectively. OSI of 7.3 and 9.4 had good sensitivity and specificity for AaDO2 cutoffs of 344 and 498, which represents moderate and severe respiratory illness, respectively. The correlation coefficients of both OSI and OI are similar against AaDO2. OSI can be used instead of OI for constant monitoring of children on mechanical ventilation. Arterial blood gas analysis and calculation of OI can be reserved for situations where SpO2 measurement is unreliable.

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Section: Discussionmentioning

confidence: 59%

Can Noninvasive Oxygen Saturation Index Match Invasive Oxygenation Index to Monitor Respiratory Disease in Critically Ill Children?—A Prospective Study

Chowdary

Doreswamy

2022

J Pediatr Intensive Care

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“…An arterial access may not be routinely performed in mildly to moderately ill newborns due to the risks associated with it. Studies have assessed the e cacy of using modi ed versions of OI, such as oxygenation saturation index (OSI, replacing PaO 2 with blood oxygen saturation using pulse oximetry, or SpO 2 , in index calculation) or respiratory severity scores (RSS, the product of MAP and FiO 2 ) as surrogate markers for pulmonary illness [28][29][30][31][32][33][34]. One recent study showed a strong correlation between OI and OSI in the neonatal population [32].…”

Section: Discussionmentioning

confidence: 99%

Oxygenation index in the first 21 days of life is a predictor for bronchopulmonary dysplasia grade in very preterm infants

Chou

Leigh

Rao

et al. 2022

Preprint

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Background BPD grades are associated with long-term respiratory and neurodevelopmental outcomes. Identification of additional early-life predictors is in need to improve the performance of their early prediction. The objective of the study was to assess the association of the oxygenation index (OI) trajectory in the first three weeks of life with BPD grades. Methods A single-center retrospective study was performed. Generalized additive mixed modeling was used to model OI trajectories for each BPD grade subgroup. A multinomial regression model was then developed to quantify the relationship between OI dynamics and the odds of BPD grades. Results 254 infants were identified for inclusion in the trajectory modeling, including 242 infants with sufficient OI data for multinomial regression analysis. A total of 6,243 OI data points were available for modeling. Average OI change was − 0.33 ± 0.52 (n = 85) in the No-BPD group, -0.04 ± 0.75 (n = 82) in the Low-Grade BPD group, and 0.22 ± 0.65 (n = 75) in the High-Grade BPD group. OI modeling showed distinct trajectory patterns for the No-BPD, Low-Grade, and High-Grade BPD subgroups. A multinomial regression analysis showed that the initial OI value and the average OI daily change in the first 3 weeks of life both independently correlated with BPD grade outcomes after adjusting for birth gestation, birth weight z-score, and sex. Conclusion Early-life OI trajectory is a useful marker for BPD grade prediction. Prospective studies are needed to further validate the findings. Alternatives to OI, such as respiratory severity score or oxygen saturation index, also merit further studies to improve clinical usability.

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“…The OSI uses oxygen saturation -SpO 2 instead of PaO 2 , which is noninvasive and can be measured continuously. The studies found a strong correlation between OSI and OI in neonates [3,4].…”

mentioning

confidence: 85%

Oxygen Saturation Index to Predict Surfactant Requirement in Preterm Infants

et al. 2022

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Accuracy of oxygen saturation index in determining the severity of respiratory failure among preterm infants with respiratory distress syndrome

Cited by 20 publications

References 15 publications

Can Noninvasive Oxygen Saturation Index Match Invasive Oxygenation Index to Monitor Respiratory Disease in Critically Ill Children?—A Prospective Study

Can Noninvasive Oxygen Saturation Index Match Invasive Oxygenation Index to Monitor Respiratory Disease in Critically Ill Children?—A Prospective Study

Oxygenation index in the first 21 days of life is a predictor for bronchopulmonary dysplasia grade in very preterm infants

Oxygen Saturation Index to Predict Surfactant Requirement in Preterm Infants

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