Accuracy rate of frozen section studies in ovarian cancers: A regional cancer institute experience

Subbian, Anbukkani; Devi, U. K.; Bafna, U. D.

doi:10.4103/0019-509x.123599

Cited by 35 publications

(26 citation statements)

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“…The pathologist of other sections may not be familiar with diagnostic clues and FS may become difficult. In spite of these disadvantages overall diagnostic accuracy of FS was reported to be reliable in large series ranging from 84.25% to 97.1%, which was 96.5% in our study (1,(3)(4)(5)(6)(7). We think that attendance of the gynecopathologist to gross examination is a very important factor to increase the diagnostic accuracy of FS.…”

Section: Discussionmentioning

confidence: 73%

Intraoperative frozen section in ovarian neoplasms; a tertiary center experience

Acikalin

Torun²,

Bağır³

et al. 2014

TJPATH

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Objective: Frozen section is an accurate diagnostic tool with some unavoidable pitfalls in gynecologic tumors. We aimed to evaluate the diagnostic value of frozen section, and to detect the factors causing erroneous diagnosis in ovarian tumors. Material and Method:Frozen section and paraffin section reports of 282 patients with ovarian neoplasms diagnosed between July 2006 and January 2013 in our institute were re-analyzed. Results were grouped into benign, borderline (for epithelial tumors) and malignant categories and compared between frozen section and paraffin section diagnosis, statistically. Results:Overall diagnostic accuracy of frozen section was 96.5%. Sensitivity of frozen section for benign, borderline and malignant tumors were 97.5%, 95.8%, and 95.6% and the related specificities were 97.5%, 97.6%, and 100%, respectively. We found the lowest positive predictive value in borderline group (79.3%), all of them with mucinous type epithelium. Second frequent discordant tumor type was immature teratoma. Conclusion:Apart from the limitations of frozen section, pathologists should be aware of the pitfalls of technique and tumor types and tend to sample from the solid areas particularly in mucinous tumors and teratomas to avoid inappropriate surgery. Bulgular:Frozen incelemenin genel tanısal doğruluk oranı %96,5 idi. Benign, borderline ve malign tümörler için frozen incelemenin duyarlığı sırasıyla %97,5, %95,8 ve %95,6 idi. Özgüllük ise aynı sırayla, %97,5, %97,6 ve %100 idi. En düşük pozitif prediktif değer borderline grubunda saptandı (%79,3) ve hataya neden olan tüm olgular müsinöz tip epitelyal tümörler idi. Tanı uyumsuzluğu bulunan ikinci tümör grubu ise immatür teratom idi. Sonuç:Frozen incelemenin kısıtlılıkları yanısıra, patoloğun frozen incelemenin teknik veya tümör tipi ile ilgili tuzaklarını bilmesi, özel-likle müsinöz tümörler ve teratom olgularında solid görünen alanlardan örneklenmesi yetersiz veya gereksiz operasyon yapılmasını önlemek adına yararlı olacaktır.

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Section: Discussionmentioning

confidence: 73%

Intraoperative frozen section in ovarian neoplasms; a tertiary center experience

Acikalin

Torun²,

Bağır³

et al. 2014

TJPATH

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“…Selain itu, akurasi histopatologi potong beku untuk menentukan keganasan pada kelompok tumor musinosum dan nonmusinosum dibandingan dengan hasil sensitivitas rendah pada tumor borderline dan kelompok musinosum. Melalui penelitian tersebut dapat disimpulkan histopatologi potong beku akurat untuk mendiagnosis tumor ganas dan tumor jinak, namun akurasinya rendah untuk mendiagnosis tumor borderline dan tumor musinosum 4 .…”

Section: Pendahuluanunclassified

“…Spesifisitas pada tumor jinak, borderline, dan ganas adalah 92%, 95,3%, dan 96,4%. Nilai prediksi positif paling rendah ditemukan pada tumor borderline yaitu 60% 4 . Oleh karena itu dapat disimpulkan pemeriksaan potong beku akurat dalam mendiagnosis tumor ovarium tipe nonmusinosum, namun sensitivitas dan nilai prediksi positifnya rendah pada tumor borderline.…”

Section: Hasil Uji Diagnostik Histopatologi Potong Beku Pada Tumor Ovunclassified

Akurasi Potong Beku Intraoperatif dalam Mendiagnosis Tumor Ovarium di Laboratorium Patologi Anatomi RSUP Dr. Mohammad Hoesin Palembang

Arnila

Dewi

Triwani³

2019

JKK

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Pemeriksaan histopatologi potong beku merupakan analisis histologi secara cepat pada massa ovarium saat pembedahan,namun tes ini relatif lebih rendah kualitasnya dibandingkan dengan pemeriksaan histopatologi rutin sebagai standar baku emas. Penelitian dilakukan untuk mengetahui akurasi pemeriksaan histopatologi potong beku dibandingkan dengan histopatologi rutin dalam mendiagnosis tumor ovarium di bagian Patologi Anatomi RSUP dr. Mohammad Hoesin Palembang periode Januari 2014-Agustus 2017.Penelitian ini menggunakan uji diagnostik untuk mengetahui akurasi dari pemeriksaan histopatologi potong beku tumor ovarium. Penelitian melibatkan 295 pasien yang dipilih menggunakan consecutive sampling, dari data pasien dihitung nilai sensitivitas, spesifisitas, nilai prediksi positif, nilai prediksi negatif, dan akurasi.Didapatkan akurasi pemeriksaan potong beku untuk menentukan potensi keganasan tumor ovarium sebesar 90%. Sebanyak 29 kasus dengan perbedaan diagnosis, yaitu 17 kasus negatif palsudan 12 kasus positif palsu. Tumor ganas memiliki sensitivitas paling besar yaitu 91% dengan spesifisitas 94%, untuk tumor jinak didapatkan sensitivitas 90% dan spesifisitas 95%, sedangkan pada tumor borderline didapatkan sensitivitas paling rendah yaitu 78% dengan spesifisitas 97%. Akurasi pemeriksaan potong beku untuk tumor ovarium tipe musinosum sebesar 87% sedangkan untuk tipe non-musinosum sebesar 91%.Penelitian ini menunjukkan bahwa pemeriksaan potong beku cukup akurat untuk menentukan potensi keganasan tumor ovarium, walaupun sensitivitasnya untuk menentukan tumor borderline lebih rendah dibandingkan untuk tumor jinak dan ganas.

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“…10,15,16 Several factors can affect the accuracy of frozen section diagnosis, such as patient characteristics, tumor size, histological type, and the pathologist's experience. 10,15 Histological typing of ovarian neoplasm followed the International Federation of Gynecology and Obstetrics (FIGO) recommendations. 17 The accuracy of frozen section for ovarian neoplasm has not been reported yet in our hospital, so we would like to evaluate the accuracy of frozen section for ovarian neoplasm in our hospital.…”

Section: Introductionmentioning

confidence: 99%

Accuracy of Intraoperative Frozen Section in Diagnosing Malignancy of Ovarian Neoplasm

Utami

Iskandar

Tanamas

et al. 2016

Indones J Obstet Gynecol

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Objective: To evaluate the accuracy of frozen section for ovarian neoplasm in our hospital. Method: A retrospective evaluation was conducted on medical records of patients with ovarian neoplasms who underwent a frozen section laparotomy between the years 2008 and 2013 at Dr. Cipto Mangunkusumo Hospital. Records with incomplete data on frozen section or paraffin block report were excluded. Criteria for frozen section laparotomy in our facility was based on a malignancy score of equal to or more than 6. Frozen section reports were compared to paraffin block report based on benign, borderline, or malignant cases. Result: From 139 patients with ovarian neoplasm, only 91 patients fulfilled the inclusion and exclusion criteria. Frozen section examination revealed benign cases was 15.4%, borderline cases was 15.4%, and malignant cases was 69.2%. Based on histopathological type, clear cell cystoadenocarcinoma was the most commonly observed histotype (19.8%). The sensitivity of frozen section for benign, borderline, and malignancy cases respectively was 81.8%, 76.9%, 91.0%. The specificity of frozen section for benign, borderline, and malignancy case respectively was 93.8%, 94.8%, 91.6%. Conclusion: We found that the accuracy of intraoperative frozen section in our facility is adequate to diagnose ovarian neoplasm and can be used to assist in determining the extent of surgical management. [Indones J Obstet Gynecol 2015; 3: 161-164] Keywords: frozen section, ovarian neoplasm, paraffin block, sensitivity, specitificity

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Accuracy rate of frozen section studies in ovarian cancers: A regional cancer institute experience

Abstract: The present study concurs that frozen section is an accurate test for diagnosis of benign and malignant tumors. However, accuracy rates for borderline and mucinous tumors are low.

Cited by 35 publications

References 1 publication

Intraoperative frozen section in ovarian neoplasms; a tertiary center experience

Intraoperative frozen section in ovarian neoplasms; a tertiary center experience

Akurasi Potong Beku Intraoperatif dalam Mendiagnosis Tumor Ovarium di Laboratorium Patologi Anatomi RSUP Dr. Mohammad Hoesin Palembang

Accuracy of Intraoperative Frozen Section in Diagnosing Malignancy of Ovarian Neoplasm

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