Accurate 3D temperature dosimetry during hyperthermia therapy by combining invasive measurements and patient-specific simulations

Verhaart, René F.; Verduijn, Gerda M.; Fortunati, Valerio; Rijnen, Z.; Walsum, Theo van; Veenland, Jifke F.; Paulides, Margarethus M.

doi:10.3109/02656736.2015.1052855

Cited by 46 publications

(61 citation statements)

References 32 publications

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“…HTP tools have been clinically evaluated and validated [75,76]. Recently, Hyperplan predicted both the occurrence of discomfort and its location in a cohort of 30 patients with an error of the temperature prediction lower than 4 °C [77].…”

Section: New Solutions To Guide Laser Ablationmentioning

confidence: 99%

Laser Ablation for Cancer: Past, Present and Future

Schena

Saccomandi

Fong

2017

JFB

144

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Laser ablation (LA) is gaining acceptance for the treatment of tumors as an alternative to surgical resection. This paper reviews the use of lasers for ablative and surgical applications. Also reviewed are solutions aimed at improving LA outcomes: hyperthermal treatment planning tools and thermometric techniques during LA, used to guide the surgeon in the choice and adjustment of the optimal laser settings, and the potential use of nanoparticles to allow biologic selectivity of ablative treatments. Promising technical solutions and a better knowledge of laser-tissue interaction should allow LA to be used in a safe and effective manner as a cancer treatment.

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Section: New Solutions To Guide Laser Ablationmentioning

confidence: 99%

Laser Ablation for Cancer: Past, Present and Future

Schena

Saccomandi

Fong

2017

JFB

144

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“…We studied two temperature models optimised constant values (x const. ) -blood perfusion and thermal conductivity as reported by Verhaart et al [21], optimised to minimise the difference between measured and predicted temperature profiles. temperature dependent perfusion (x Tdep. )…”

Section: Em and Temperature Calculationsmentioning

confidence: 99%

“…Internal air together with metal implants and lung were inactive in the temperature simulations and modelled using mixed boundary condition with heat transfer rate h ¼ 82 W/m 2 ÁK and h ¼ 50 W/m 2 ÁK, respectively and temperatures of 20 C and 37 C. Boundary conditions with h ¼ 8 W/m 2 ÁK and temperatures of 20 C were used for external air and the headrest [21].…”

Section: Em and Temperature Calculationsmentioning

confidence: 99%

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Hyperthermia treatment planning guided applicator selection for sub-superficial head and neck tumors heating

Drizdal

Paulides

Holthe

et al. 2017

International Journal of Hyperthermia

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Purpose: In this study, we investigated the differences in hyperthermia treatment (HT) quality between treatments applied with different hyperthermia systems for sub-superficial tumours in the head and neck (H&N) region. Materials and methods: In 24 patients, with a clinical target volume (CTV) extending up to 6 cm from the surface, we retrospectively analysed the predicted HT quality achievable by two planar applicator arrays or one phased-array hyperthermia system. Hereto, we calculated and compared the specific absorption rate (SAR) and temperature distribution coverage of the CTV and gross tumour volume (GTV) for the Lucite cone applicator (LCA: planar), current sheet applicator (CSA: planar) and the HYPERcollar (phased-array). Results: The HYPERcollar provides better SAR coverage than planar applicators if the target region is fully enclosed by its applicator frame. For targets extending outside the HYPERcollar frame, sufficient SAR coverage (25% target coverage, i.e. TC25 ! 75%) can still be achieved using the LCA when the target is fully under the LCA aperture and not deeper than 50 mm from the patient surface. Conclusion: Simulations predict that the HYPERcollar (hence also its successor the HYPERcollar3D) is to be preferred over planar applicators such as LCA and current sheet applicator in sub-superficial tumours in the H&N region when used within specifications. ARTICLE HISTORY

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“…Temperature sensors used in hyperthermia are mostly thermocouples, even if thermistors (Browman probes 14 ) and fiber optic sensors are also used. 15 However, these sensors allow getting information only in some locations into the body. Other techniques that could be used for monitoring the temperature would be MRI, CT, ultrasound (US).…”

Section: Introductionmentioning

confidence: 99%

Human body models for validation studies of deep hyperthermia

Toseroni

Ciampa²,

Cavagnaro

2017

Int J RF Microw Comput Aided Eng

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Hyperthermia is a therapeutic technique used to enhance the efficacy of radiotherapy and chemotherapy in the treatment of oncological pathologies, by way of a temperature increase of 41–43°C in the target region. To validate hyperthermia devices, as well as the numerical codes used to simulate hyperthermia treatments, simple phantoms are used. This article considers the influence of phantoms’ geometry, dimensions, and considered organs, on the electromagnetic power absorption. Aim of the study was to evaluate the representativeness of such simple phantoms in terms of the power absorbed by the organs target of deep hyperthermia treatments (i.e., uterus and bladder). In particular, attention was posed on the influence of the visceral fat on the distribution of the absorbed power among the different organs. Results show that geometry and dimension does not influence the distribution of the absorbed power among the different tissues/organs (the maximum difference is 4% in the bladder). However, neglecting the presence of visceral fat greatly changes the electromagnetic power absorbed by the target organs, leading to a 23% increase of the percentage power absorbed in the uterus with respect to the complete model. This percent value corresponded to an increase in the volume‐averaged SAR of 140%.

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Accurate 3D temperature dosimetry during hyperthermia therapy by combining invasive measurements and patient-specific simulations

Cited by 46 publications

References 32 publications

Laser Ablation for Cancer: Past, Present and Future

Laser Ablation for Cancer: Past, Present and Future

Hyperthermia treatment planning guided applicator selection for sub-superficial head and neck tumors heating

Human body models for validation studies of deep hyperthermia

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