Accurate and Real-Time Temperature Monitoring during MR Imaging Guided PTT

Abstract

Photothermal therapy (PTT) is an efficient approach for cancer treatment. However, accurately monitoring the spatial distribution of photothermal transducing agents (PTAs) and mapping the real-time temperature change in tumor and peritumoral normal tissue remain a huge challenge. Here, we propose an innovative strategy to integrate T 1 -MRI for precisely tracking PTAs with magnetic resonance temperature imaging (MRTI) for real-time monitoring temperature change in vivo during PTT. NaBiF 4 : Gd@PDA@PEG nanomaterials were synthesized with favorable T 1 -weighted performance to target tumor and localize PTAs. The extremely weak susceptibility (1.04 × 10 −6 emu g −1 Oe 1− ) of NaBiF 4 : Gd@PDA@PEG interferes with the local phase marginally, which maintains the capability of MRTI to dynamically record real-time temperature change in tumor and peritumoral normal tissue. The time resolution is 19 s per frame, and the detection precision of temperature change is approximately 0.1 K. The approach achieving PTT guided by multimode MRI holds significant potential for the clinical application.

Manganese Ferrite Nanoparticles Encapsulated into Vitamin E/Sphingomyelin Nanoemulsions as Contrast Agents for High‐Sensitive Magnetic Resonance Imaging

“…Moreover, besides the common function of anatomical MRI, contrast agents based on nanomaterials can also be exploited for functional MRI applications, such as the real-time monitorization of the tumor temperature induced by photothermal therapy and the detection of specific molecule concentrations present in the tumor microenvironment. [5,6] Taking this into consideration, promising in vitro and preclinical results have been demonstrated, ending up with magnetic nanoparticles for example, already included in clinical programs. [7] When it comes to magnetic nanoparticles, their magnetic moment is capable of inducing field inhomogeneities in the surrounding environment (typically composed by water molecules when the nanoparticles are immersed in tissue) when a radiofrequency pulse is applied.…”

Thermal analysis of laser irradiation-gold nanorod combinations at 808 nm, 940 nm, 975 nm and 1064 nm wavelengths in breast cancer model

“…For instance, it could be assessed by the use of thermocouples and minimally-invasive fiber optic sensors, which have already shown promising results for thermal monitoring during PTT of breast tumor models [20,21]. Additionally, magnetic resonance imaging has been presented to enable the reconstruction of two-and three-dimensional thermal maps to attain an estimation of temperature change of the cancerous region and the surrounding healthy tissue during PTT [57].…”

Inorganic–inorganic nanohybrids for drug delivery, imaging and photo-therapy: recent developments and future scope

“…This approach helps to achieve MRI/guided PTT for a wide variety of relevant clinical applications. 150 Biocompatible PTT agents are of greatest interest as they can facilitate theranosis in a better way than conventional PTT agents. In order to achieve this, a Gd-modified CuS nano-theranostic agent (Gd:CuS@BSA) was prepared with a BSA bio-template ( Fig.…”