ACE deletion allele is associated with susceptibility to SARS-CoV-2 infection and mortality rate: An epidemiological study in the Asian population

Pati, Abhijit; Mahto, Harishankar; Padhi, Sunali; Panda, Aditya K.

doi:10.1016/j.cca.2020.08.008

Cited by 67 publications

(83 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The European population has a lower ACE1 II genotype frequency and a higher prevalence of infected patients and mortality due to COVID-19 than the Asian population [ 78 ]. These data are consistent with an epidemiological study that reported a significant positive correlation of the D allele with SARS-CoV-2 infection prevalence and mortality rate in Asian population [ 79 ]. The DD genotype was also increased in acute respiratory distress syndrome [ 80 ].…”

Section: Genetic Polymorphismsupporting

confidence: 92%

What could explain the late emergence of COVID-19 in Africa?

Lalaoui¹,

Bakour²,

Raoult³

et al. 2020

New Microbes and New Infections

View full text Add to dashboard Cite

At the end of November 2019, a novel coronavirus responsible for respiratory tract infections emerged in China. Despite drastic containment measures, this virus, known as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), spread in Asia and Europe. The pandemic is ongoing with a particular hotspot in southern Europe and America in spring 2020. Many studies predicted an epidemic in Africa similar to that currently seen in Europe and the USA. However, reported data do not confirm these predictions. Several hypotheses that could explain the later emergence and spread of the coronavirus disease 2019 (COVID-19) pandemic in African countries are being discussed, including the lack of health-care infrastructure capable of clinically detecting and confirming COVID-19 cases, the implementation of social distancing and hygiene, international air traffic flows, the climate, the relatively young and rural population, the genetic polymorphism of the angiotensin-converting enzyme 2 receptor, cross-immunity and the use of antimalarial drugs.

show abstract

Section: Genetic Polymorphismsupporting

confidence: 92%

What could explain the late emergence of COVID-19 in Africa?

Lalaoui¹,

Bakour²,

Raoult³

et al. 2020

New Microbes and New Infections

View full text Add to dashboard Cite

show abstract

“…ACE1-DD carriers have higher blood levels of ACE, approximately twice when compared to ACE1-II individuals, and have been associated with hypertension, ARDS, and in-hospital mortality [ 146 – 148 ]. Therefore, the deletion allele is associated with COVID-19 progression [ 89 ] and SARS-CoV-2 infection rate and mortality [ 147 ], while the ACE1-II genotype negatively correlates with infection rate and mortality [ 149 ]. However, a meta-analysis (48,758 healthy subjects from 30 different countries) significantly associated ACE1-I/D allele frequency ratio with the increase in the recovery rate, but not with mortality [ 150 ].…”

Section: Ace1/ace2 Gene Polymorphismsmentioning

confidence: 99%

COVID-19: angiotensin-converting enzyme 2 (ACE2) expression and tissue susceptibility to SARS-CoV-2 infection

Beyerstedt

Casaro

Rangel

2021

Eur J Clin Microbiol Infect Dis

631

481

View full text Add to dashboard Cite

“…According to the available data, the frequency of D allele is positively correlated with the number of SARS-CoV-2 infection cases in Asians and African Americans. 32 , 54 Owing to the combined effect of D allele and SARS-CoV-2 infection, the high ACE levels and decreased ACE2 levels lead to a high amount of Ang II in plasma and tissues and eventually result in severe lung injury and even death.…”

Section: Role Of Ras In Ali Caused By Coronavirus Infectionsmentioning

confidence: 99%

<p>Role of Renin-Angiotensin System in Acute Lung Injury Caused by Viral Infection</p>

Gao¹,

Du²,

Zhang³

et al. 2020

IDR

View full text Add to dashboard Cite

The renin-angiotensin system (RAS) is the most important regulatory system of electrolyte homeostasis and blood pressure and acts through angiotensin-converting enzyme (ACE)/angiotensin II (Ang II)/Ang II type 1 (AT1) receptor axis and angiotensin-converting enzyme 2 (ACE2)/angiotensin (1-7)/MAS receptor axis. RAS dysfunction is related to the occurrence and development of acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) and causes a serious prognosis and even death. ALI/ARDS can be induced by various ways, one of which is viral infections, such as SARS-CoV, SARS-CoV-2, H5N1, H7N9, and EV71. This article reviews the specific mechanism on how RAS dysfunction affects ALI/ARDs caused by viral infections. SARS-CoV and SARS-CoV-2 enter the host cells by binding with ACE2. H5N1 and H7N9 avian influenza viruses reduce the ACE2 level in the body, and EV71 increases Ang II concentration. Treatment with angiotensin-converting enzyme inhibitor and angiotensin AT1 receptor blocker can alleviate ALI/ARDS symptoms. This review provides suggestions for the treatment of lung injury caused by viral infections.

show abstract

ACE deletion allele is associated with susceptibility to SARS-CoV-2 infection and mortality rate: An epidemiological study in the Asian population

Abstract: Highlights Differential distribution of ACE I/D polymorphism observed in Asian countries. Allele D of ACE I/D polymorphism was associated with susceptibility to SARS-CoV-2 infection. The minor allele of ACE I/D was linked with COVID-19 mortality in the Asian population.

Cited by 67 publications

References 24 publications

What could explain the late emergence of COVID-19 in Africa?

What could explain the late emergence of COVID-19 in Africa?

COVID-19: angiotensin-converting enzyme 2 (ACE2) expression and tissue susceptibility to SARS-CoV-2 infection

<p>Role of Renin-Angiotensin System in Acute Lung Injury Caused by Viral Infection</p>

Contact Info

Product

Resources

About