Acetaminophen Hepatotoxicity: Current Management

Tan, Hui Shan; Chang, Charissa; Martin, Paul

doi:10.1002/msj.20065

Cited by 11 publications

(7 citation statements)

References 86 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…There have been no reports of beneficial therapies, other than the use of N-acetylcysteine for acetaminophen hepatotoxicity 44. Corticosteroid therapy may be used in DILI cases with evident hypersensitivity, but it does not have proven benefits.…”

Section: Introductionmentioning

confidence: 99%

Drug-induced liver injury: present and future

2012

View full text Add to dashboard Cite

Liver injury due to prescription and nonprescription medications is a growing medical, scientific, and public health problem. Worldwide, the estimated annual incidence rate of drug-induced liver injury (DILI) is 13.9-24.0 per 100,000 inhabitants. DILI is one of the leading causes of acute liver failure in the US. In Korea, the annual extrapolated incidence of cases hospitalized at university hospital is 12/100,000 persons/year. Most cases of DILI are the result of idiosyncratic metabolic responses or unexpected reactions to medication. There is marked geographic variation in relevant agents; antibiotics, anticonvulsants, and psychotropic drugs are the most common offending agents in the West, whereas in Asia, 'herbs' and 'health foods or dietary supplements' are more common. Different medical circumstances also cause discrepancy in definition and classification of DILI between West and Asia. In the concern of causality assessment, the application of the Roussel Uclaf Causality Assessment Method (RUCAM) scale frequently undercounts the cases caused by 'herbs' due to a lack of previous information and incompatible time criteria. Therefore, a more objective and reproducible tool that could be used for the diagnosis of DILI caused by 'herbs' is needed in Asia. In addition, a reporting system similar to the Drug-Induced Liver Injury Network (DILIN) in the US should be established as soon as possible in Asia.

show abstract

Section: Introductionmentioning

confidence: 99%

Drug-induced liver injury: present and future

2012

View full text Add to dashboard Cite

show abstract

“…There are no reports of beneficial therapies, other than the use of N-acetylcysteine for acetaminophen-induced liver injury. 94 Empiric use of corticosteroids in acute liver failure due to DILI is not recommended due to the lack of benefit in previously reported studies but is still sometimes used in patients with severe DILI. 95 Steroid therapy may be useful in DILI cases associated with hypersensitivity features, such as is the case with carbamazepine-induced hepatotoxicity.…”

Section: Treatmentmentioning

confidence: 99%

Drug Induced Liver Injury: Review with a Focus on Genetic Factors, Tissue Diagnosis, and Treatment Options

Khoury

Rmeileh

Yosha

et al. 2015

JCTH

View full text Add to dashboard Cite

Drug-induced liver injury (DILI) is a rare but potentially life threatening adverse drug reaction. DILI may mimic any morphologic characteristic of acute or chronic liver disease, and the histopathologic features of DILI may be indistinguishable from those of other causes of liver injury, such as acute viral hepatitis. In this review article, we provide an update on causative agents, clinical features, pathogenesis, diagnosis modalities, and outcomes of DILI. In addition, we review results of recently reported genetic studies and updates on pharmacological and invasive treatments.

show abstract

“…Discontinuation of the potentially offending agents is the most important step in the treatment of DILI. No other specific therapies are suggested other than the use of N‐acetylcysteine for acetaminophen hepatotoxicity . Liver‐protective drugs are frequently used in the clinic to prevent further damage of the liver; therefore, inadequate evidence was available to judge the effectiveness and safety of them.…”

Section: Diagnosis and Management Of Dili In Chinamentioning

confidence: 99%