Acetylcholinesterase histochemistry in the macaque thalamus reveals territories selectively connected to frontal, parietal and temporal association cortices

Cavada, Carmen; Hernández-González, Amalia; Reinoso‐Suárez, Fernando

doi:10.1016/0891-0618(95)00050-h

Cited by 45 publications

(41 citation statements)

References 35 publications

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“…Other studies have also noted the connection of the orbital surface of the frontal lobe with PM (Kievit and Kuypers 1977;Morecraft et al, 1992;Cavada et al, 1995). Our findings are also in agreement with Kievit and Kuypers (1977) who reported connections between area 10 and caudomedial PM and between the dorso-lateral surface of the frontal lobe and central/lateral portions of PM.…”

Section: Pm Projections To the Prefrontal Cortexsupporting

confidence: 95%

Topographic organization of medial pulvinar connections with the prefrontal cortex in the rhesus monkey

et al. 1997

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The medial nucleus of the pulvinar complex (PM) has widespread connections with association cortex. We investigated the connections of the PM with the prefrontal cortex (PFC) in macaque monkeys, with tracers placed into the PM and the PFC, respectively. Injections of wheat germ agglutinin-horseradish peroxidase (WGA-HRP) placed into the PM resulted in widespread anterograde terminal labeling in layers III and IV, and retrograde cellular labeling in layer VI of the PFC. Injections of tracers centered on the central/lateral PM resulted in labeling of dorsolateral and orbital regions, whereas injections centered on caudal, medial PM resulted in labeling of dorsomedial and medial PFC. Since injections of the PM included neighboring thalamic nuclei, retrograde tracers were placed into distinct cytoarchitectonic regions of the PFC and retrogradely labeled cells in the posterior thalamus were charted. The results of this series of tracer injections confirmed the results of thalamic injections. Injections placed into areas 8a, 12 (lateral and orbital), 45, 46 and 11, retrogradely labeled neurons in the central/lateral PM, while tracer injections placed into areas 9, 12 (lateral), 10 and 24, labeled medial PM. The connections of the PM with temporal, parietal, insular, and cingulate cortices were also examined. The central/lateral PM has reciprocal connections with posterior parietal areas 7a, 7ip, and 7b, insular cortex, caudal superior temporal sulcus (STS), caudal superior temporal gyrus (STG), and posterior cingulate, whereas medial PM is connected mainly with the anterior STS and STG, as well as the cingulate cortex and the amygdala. These connectional studies suggest that the central/ lateral and medial PM have divergent connections which may be the substrate for distinct functional circuits.

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Section: Pm Projections To the Prefrontal Cortexsupporting

confidence: 95%

Topographic organization of medial pulvinar connections with the prefrontal cortex in the rhesus monkey

et al. 1997

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“…Indeed, distinct AChE staining patterns within PM distinguish sectors that project to orbitofrontal cortex from others with parietal and temporal association cortex connections (Cavada et al, 1995). These findings are compatible with the present observations, based on three different architectonic stains, indicating a division of the medial pulvinar into two broad neurochemical zones, PMl and PMm, each with distinctive patterns of cortical connections.…”

Section: Neurochemical Organization Of the Dorsal Pulvinarsupporting

confidence: 86%

Neurochemical and connectional organization of the dorsal pulvinar complex in monkeys

et al. 2000

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“…Names for the human thalamic nuclei followed the nomenclature by Hirai and Jones (1989); for the monkey thalamic nuclei, we used Olszewski's nomenclature (Olszewski, 1952) with some modifications (Cavada et al, 1995;Rico and Cavada, 1998).…”

Section: Methodsmentioning

confidence: 99%

“…Adjacent series of sections were processed to reveal the cytoarchitecture, myeloarchitecture, and chemoarchitecture of the thalamus using cresyl violet staining, silver myelin staining (Gallyas, 1979), and acetylcholinesterase histochemistry, respectively. The acetylcholinesterase activity, which is particularly useful for identifying the thalamic nuclei, was revealed using the protocol described by Cavada et al (1995).…”

Section: Methodsmentioning

confidence: 99%

The Primate Thalamus Is a Key Target for Brain Dopamine

Sánchez-González

García‐Cabezas²,

Rico³

et al. 2005

J. Neurosci.

283

187

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The thalamus relays information to the cerebral cortex from subcortical centers or other cortices; in addition, it projects to the striatum and amygdala. The thalamic relay function is subject to modulation, so the flow of information to the target regions may change depending on behavioral demands. Modulation of thalamic relay by dopamine is not currently acknowledged, perhaps because dopamine innervation is reportedly scant in the rodent thalamus. We show that dopaminergic axons profusely target the human and macaque monkey thalamus using immunolabeling with three markers of the dopaminergic phenotype (tyrosine hydroxylase, dopamine, and the dopamine transporter). The dopamine innervation is especially prominent in specific association, limbic, and motor thalamic nuclei, where the densities of dopaminergic axons are as high as or higher than in the cortical area with the densest dopamine innervation. We also identified the dopaminergic neurons projecting to the macaque thalamus using retrograde tract-tracing combined with immunohistochemistry. The origin of thalamic dopamine is multiple, and thus more complex, than in any other dopaminergic system defined to date: dopaminergic neurons of the hypothalamus, periaqueductal gray matter, ventral mesencephalon, and the lateral parabrachial nucleus project bilaterally to the monkey thalamus. We propose a novel dopaminergic system that targets the primate thalamus and is independent from the previously defined nigrostriatal, mesocortical, and mesolimbic dopaminergic systems. Investigating this "thalamic dopaminergic system" should further our understanding of higher brain functions and conditions such as Parkinson's disease, schizophrenia, and drug addiction.

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Acetylcholinesterase histochemistry in the macaque thalamus reveals territories selectively connected to frontal, parietal and temporal association cortices

Cited by 45 publications

References 35 publications

Topographic organization of medial pulvinar connections with the prefrontal cortex in the rhesus monkey

Topographic organization of medial pulvinar connections with the prefrontal cortex in the rhesus monkey

Neurochemical and connectional organization of the dorsal pulvinar complex in monkeys

The Primate Thalamus Is a Key Target for Brain Dopamine

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