Achillea millefolium L. s.l. – Is the anti-inflammatory activity mediated by protease inhibition?

The In Vitro Inhibition of Human Neutrophil Elastase Activity by some Yemeni Medicinal Plants

“…The remaining activity of HNE activity (as % of the control) was calculated in comparison to the control without inhibitor, considering the influence of the buffer, substrate, solvent and test extract. The inhibitory effect of the selective HNE inhibitor GW 311616A (IC 50 =0.04 µg/ml) that was already tested by using the same assay [28] was considered as a positive control.…”

“…Since the past decade, natural compounds and plant extracts have been the targets of research as a potential source to explore for efficient elastase inhibitors [24][25][26][27][28]. The aim of this study was therefore to investigate the effects of a variety of extracts from some Yemeni plants on the activity of human neutrophil elastase.…”

Essential oil content and composition ofAchillea biebersteiniiAfan. in different plant parts and phenological stages

“…In traditional systems of medicine, Achillea species have a long history of use as medicinal plants mainly due to their anti-inflammatory, anti-spasmodic, diaphoretic, diuretic, carminative, tunic, vermifugal and emmenagogic properties and are used as a cure for hemorrhage, pneumonia, rheumatic and abdominal pains, stomach-ache and wounds (4,5,6). Nowadays, different medicinal properties of these plants such as spasmolytic, choleretic, anti-inflammatory and wound healing are documented (7). In recent years, anticancer activity of essential oils isolated from some Achillea species has been reported and it has been shown that they can modulate macrophage activities (8).…”

The in vitro inhibition of human neutrophil elastase activity by some Yemeni medicinal plants

“…The validation of this assay was tested by using the selective HNE inhibitor GW 311616A (Positive control, IC 50 =0.04 µg/ml) [28]. Among the plants tested, A.…”