Acid-degradable lactobionic acid-modified soy protein nanogels crosslinked by ortho ester linkage for efficient antitumor in vivo

Cheng, Xu; Qin, Jiejie; Wang, Xin; Zha, Qian; Yao, Weijing; Fu, Shengxiang

doi:10.1016/j.ejpb.2018.05.011

Cited by 23 publications

(7 citation statements)

References 40 publications

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“…Finally, the content of Ca 2+ ions was determined to be 210–230 μg/mL by ICP-MS, as shown in Table S1. The modification degree of glucose was measured to be 43.42 μg/mL and 37.98 μg/mL for GA@HAP-NPs and GA@HAP/ICG-NPs by the phenol/sulfuric acid method, respectively …”

Section: Resultsmentioning

confidence: 99%

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Glucose-Targeted Hydroxyapatite/Indocyanine Green Hybrid Nanoparticles for Collaborative Tumor Therapy

Cheng

Zhang

et al. 2021

ACS Appl. Mater. Interfaces

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Nanoscale hydroxyapatite (nHA) is considered as a promising drug carrier or therapeutic agent against malignant tumors. But the strong agglomeration tendency and lack of active groups seriously hamper their usage in vivo. To address these issues, we fabricated an organic−inorganic hybrid nanosystem composed of poly(acrylic acid) (PAA), nHA, and indocyanine green (ICG), and further modified with glucose to give a targeting nanosystem (GA@HAP/ICG-NPs). These hybrid nanoparticles (∼90 nm) showed excellent storage and physiological stability assisted by PAA and had a sustained drug release in an acidic tumor environment. In vitro cell experiments confirmed that glucose-attached particles significantly promoted cellular uptake and increased intracellular ICG and Ca 2+ concentrations by glucose transporter 1 (GLUT1)-mediated endocytosis. Subsequently, the excessive Ca 2+ induced cell or organelle damage and ICG triggered photothermal and photodynamic effects (PTT/PDT) under laser irradiation, resulting in enhanced cell toxicity and apoptosis. In vivo tests revealed that the hybrid nanosystem possessed good hemocompatibility and biosafety, facilitating in vivo circulation and usage. NIR imaging further showed that tumor tissues had more drug accumulation, resulting in the highest tumor growth inhibition (87.89%). Overall, the glucose-targeted hybrid nanosystem was an effective platform for collaborative therapy and expected to be further used in clinical trials.

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Section: Resultsmentioning

confidence: 99%

“…The modification degree of glucose was measured to be 43.42 μg/mL and 37.98 μg/mL for GA@HAP-NPs and GA@HAP/ICG-NPs by the phenol/sulfuric acid method, respectively. 36 3. the interference of a complicated circulation environment for intravenous administration. Thus, the stability of various particles were evaluated in different environments.…”

Section: Resultsmentioning

confidence: 99%

Glucose-Targeted Hydroxyapatite/Indocyanine Green Hybrid Nanoparticles for Collaborative Tumor Therapy

Cheng

Zhang

et al. 2021

ACS Appl. Mater. Interfaces

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“…Because amide I was not involved in the curing reaction, the flattening of the spectra indicates the cleavage/consumption of the CC bonds during the free radical polymerization. 46,57 Figure 3b shows the tensile stress−strain curves of the MSPI films. The tensile properties of the films were calculated based on the curves and the results are summarized in Table S1.…”

Section: ■ Results and Discussionmentioning

confidence: 99%

“…A lower intensity of this region was noted with a longer curing time (the spectra were increasingly flattened). Because amide I was not involved in the curing reaction, the flattening of the spectra indicates the cleavage/consumption of the CC bonds during the free radical polymerization. , …”

Section: Resultsmentioning

confidence: 99%

UV-Curable Cellulose Nanofiber-Reinforced Soy Protein Resins for 3D Printing and Conventional Molding

Mohawk

Jahani

et al. 2020

ACS Appl. Polym. Mater.

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Plastic wastes pose a serious threat to the environment and there has been strong interest in developing soy protein isolate (SPI)-based plastics to reduce the use of traditional petroleum-based ones. However, the use of SPI plastics has been hindered due to their inferior mechanical properties and poor water resistance compared with traditional plastics. In this work, SPI plastics with significantly improved mechanical properties and water resistance were developed using UV-curable SPI resin and UVcurable cellulose nanofibers. Three UV-curable materials, i.e., methacrylated SPI (MSPI), methacrylated cellulose nanofibrils (MCNF), and methacrylated cellulose nanocrystals (MCNC), were produced through methacrylation of SPI, CNF, and CNC, respectively. Methacrylation of the materials and UV curing of the resins were confirmed using Fourier-transform infrared spectroscopy. Uniform dispersion of CNC, CNF, MCNC, or MCNF in the resin was confirmed by scanning electron microscopy and X-ray diffraction. The tensile properties and water resistance of the resins were found to improve with increasing curing time and degree of methacrylation. The incorporation of CNC, CNF, MCNC, and MCNF further improved the mechanical and water resistance performance of the resins, with the MCNF leading to the largest improvement. UV curing and the cellulose nanofibers evidently worked synergistically to improve the properties of the resins. This study demonstrated a method and formulations to produce the SPI plastics with exceptional properties. Furthermore, the potential of this resin in 3D printing and conventional plastic molding was demonstrated.

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“…As displayed in figure 2(a), compared with PBS (pH 7.4), the release rates of PTX and TET significantly increased at pH 5.5 in the same periods. The results suggest that PT@usNLC exhibits a pH-responsive drug release profile to some extent, thus could hold drugs in a neutral physiological environment while releasing drugs rapidly in the acidic tumor cells [24]. In addition, TET exhibited a faster release rate than PTX in all mediums, possibly because the TET was located in the outer lipid phases of PT@usNLC.…”

Section: The Controlled Release Behavior Of Pt@usnlcmentioning

confidence: 89%

Ultra-small lipid carriers with adjustable release profiles for synergistic treatment of drug-resistant ovarian cancer

et al. 2022

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Multidrug resistance has dramatically compromised the effectiveness of paclitaxel (PTX). The combined application of PTX and tetrandrine (TET) is a promising avenue in drug-resistant cancer therapy. However, poor drug release and limited intracellular drug accumulation greatly impede this combinational antitumor therapy. To address this problem, we successfully developed a tunable controlled release lipid platform (PT@usNLC) for coordinated drug delivery. The drug release rate of PT@usNLC can be tuned by varying the lipid ratio, which has potential to maximize the therapeutic effects of combined drugs. The TET release rate from PT@usNLC was faster than PTX, which could restore the sensitivity of tumor cells to PTX and exert a synergistic antitumor effect. The appropriate size of PT@usNLC could effectively increase the intracellular drug accumulation. Both in vitro and in vivo studies revealed that PT@usNLC significantly enhanced the therapeutic effect compared to conventional therapies. This study provides a new strategy for resistant ovarian cancer therapy.

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Acid-degradable lactobionic acid-modified soy protein nanogels crosslinked by ortho ester linkage for efficient antitumor in vivo

Cited by 23 publications

References 40 publications

Glucose-Targeted Hydroxyapatite/Indocyanine Green Hybrid Nanoparticles for Collaborative Tumor Therapy

Glucose-Targeted Hydroxyapatite/Indocyanine Green Hybrid Nanoparticles for Collaborative Tumor Therapy

UV-Curable Cellulose Nanofiber-Reinforced Soy Protein Resins for 3D Printing and Conventional Molding

Ultra-small lipid carriers with adjustable release profiles for synergistic treatment of drug-resistant ovarian cancer

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