Acid-Labile Poly(glycidyl methacrylate)-Based Star Gene Vectors

Yang, Yanyu; Hu, Hao; Wang, Xing; Yang, Fei; Shen, Hong; Xu, Fu‐Jian; Wu, Decheng

doi:10.1021/acsami.5b02733

Cited by 40 publications

(28 citation statements)

References 46 publications

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“…13 Furthermore, many strategies have been introduced to improve the intelligences of nanoparticles for gene delivery systems, such as biodegraded, PEGylated, targeted, and modified with cell-penetrating peptides or endosomolytic agents. 3 , 81 , 82 …”

Section: Production Of Nanoparticlesmentioning

confidence: 99%

Production and clinical development of nanoparticles for gene delivery

Chen

Guo

Tian

et al. 2016

Molecular Therapy - Methods & Clinical Development

233

158

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Gene therapy is a promising strategy for specific treatment of numerous gene-associated human diseases by intentionally altering the gene expression in pathological cells. A successful clinical application of gene-based therapy depends on an efficient gene delivery system. Many efforts have been attempted to improve the safety and efficiency of gene-based therapies. Nanoparticles have been proved to be the most promising vehicles for clinical gene therapy due to their tunable size, shape, surface, and biological behaviors. In this review, the clinical development of nanoparticles for gene delivery will be particularly highlighted. Several promising candidates, which are closest to clinical applications, will be briefly reviewed. Then, the recent developments of nanoparticles for clinical gene therapy will be identified and summarized. Finally, the development of nanoparticles for clinical gene delivery in future will be prospected.

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Section: Production Of Nanoparticlesmentioning

confidence: 99%

Production and clinical development of nanoparticles for gene delivery

Chen

Guo

Tian

et al. 2016

Molecular Therapy - Methods & Clinical Development

233

158

View full text Add to dashboard Cite

show abstract

“…Thanks to the unique drug encapsulation ability, CD as well as its derivatives have been successfully utilized in pharmaceutical carriers. As a typical examples, Xu and co‐workers has conjugated ethanolamine‐functionalized poly(glycidyl methacrylate) to β‐CD and proved it to be an efficient gene carrier . To be mentioned, we also reported a series of star‐shaped polymers consisting of a beta‐cyclodextrin (β‐CD) core and various functional components in the shell for enhanced therapeutic deliveries .…”

Section: Introductionmentioning

confidence: 99%

Thermoresponsive Supramolecular Chemotherapy by “V”‐Shaped Armed β‐Cyclodextrin Star Polymer to Overcome Drug Resistance

Fan

Cheng

Wang

et al. 2017

Adv Healthcare Materials

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Pump mediated drug efflux is the key reason to result in the failure of chemotherapy. Herein, a novel star polymer β-CD-v-(PEG-β-PNIPAAm) consisting of a β-CD core, grafted with thermo-responsive poly(N-isopropylacrylamide) (PNIPAAm) and biocompatible poly(ethylene glycol) (PEG) in the multiple "V"-shaped arms is designed and further fabricated into supramolecular nanocarriers for drug resistant cancer therapy. The star polymer could encapsulate chemotherapeutics between β-cyclodextrin and anti-cancer drug via inclusion complex (IC). Furthermore, the temperature induced chain association of PNIPAAm segments facilitated the IC to form supramolecular nanoparticles at 37 °C, whereas the presence of PEG impart great stability to the self-assemblies. When incubated with MDR-1 membrane pump regulated drug resistant tumor cells, much higher and faster cellular uptake of the supramolecular nanoparticles were detected, and the enhanced intracellular retention of drugs could lead to significant inhibition of cell growth. Further in vivo evaluation showed high therapeutic efficacy in suppressing drug resistant tumor growth without a significant impact on the normal functions of main organs. This work signifies thermo-responsive supramolecular chemotherapy is promising in combating pump mediated drug resistance in both in vitro and in vivo models, which may be encouraging for the advanced drug delivery platform design to overcome drug resistant cancer.

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“…Hence, a range of synthetic delivery carriers have been developed. 33,[37][38][39][40][41][42] Among them, nanoparticles (NPs) generated from amphiphilic copolymers by self-assembly have gradually attracted increasing attention in gene delivery systems because of the fact that the hydrophobic core and the hydrophilic shell significantly improve their stability and biocompatibility. 43,44 For example, we have synthesized a series of NPs with poly(depsipeptide-co-cyclic diester), polyethyleneimine (PEI) and poly(ethylene glycol) (PEG).…”

Section: Introductionmentioning

confidence: 99%