Acinar cell carcinoma of the pancreas

Kuopio, Teijo; Ekfors, T; Nikkanen, V.; Nevalainen, Timo J.

doi:10.1111/j.1699-0463.1995.tb01081.x

Cited by 52 publications

(17 citation statements)

References 28 publications

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“…Moreover, in three cases CEL showed an immunohistochemical reaction (22). Due to our single case of acinar cell carcinoma, our study does not allow a generalization of CEL's activity in this subtype of pancreatic cancer.…”

Section: Discussionmentioning

confidence: 74%

The expression of the carboxyl ester lipase gene in pancreas and pancreatic adenocarcinomas

Reuß

Aberle²,

Klingel³

et al. 2006

Int J Oncol

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Abstract. Since pancreatic cancer is an aggressive and often incurable malignancy, we investigated if the carboxyl ester lipase gene (CEL) is specifically expressed in pancreatic tissues and its promoter can be used for a specific suicide gene approach. Twenty-five tumor samples, 24 samples of normal pancreatic tissue and control tissues from other organs were examined by radioactive in situ hybridization (ISH) to localize CEL mRNA. Two carcinoma samples and 6 permanent cell lines were examined by reverse transcriptasepolymerase chain reaction (RT-PCR). By ISH, we verified a strong CEL gene expression in acinar cells of the normal pancreas. A minor expression was noted in a single sample of acinar cell carcinoma and adenocarcinomas did not show any expression. By RT-PCR, no specific expression in both tested adenocarcinomas was observed. In summary, these results show that, contrary to notable expression of carboxyl ester lipase in acinar cells of normal pancreatic tissue, this lipase is not significantly active in pancreatic adenocarcinomas and thus not an apt genetic marker for diagnostic or therapeutic approaches.

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Section: Discussionmentioning

confidence: 74%

The expression of the carboxyl ester lipase gene in pancreas and pancreatic adenocarcinomas

Reuß

Aberle²,

Klingel³

et al. 2006

Int J Oncol

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“…Most acinar cell carcinomas are large with a mean size of 10 cm and are easily appreciated on radiologic examination [8]. The mass formed by acinar cell carcinomas is often better defined than those formed by ductal adenocarcinomas, which sometimes help in distinguishing the two entities, but the radiologic findings are non-specific (Fig.…”

Section: Radiologic Featuresmentioning

confidence: 99%

Acinar Cell Carcinoma of the Pancreas: A Literature Review and Update

Chaudhary

2014

Indian J Surg

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Pancreatic acinar cell carcinoma is a rare tumour, accounting for only about 1 % of all pancreatic tumours. The long-term survival for patients with acinar cell carcinoma is significantly better than the long-term survival of patients with pancreatic adenocarcinoma. As no large series of patients with acinar cell carcinomas exist, our understanding of this disease comes mainly from small case series and case reports. Aggressive surgical resection with negative margins is associated with long-term survival in these more favourable pancreatic cancers. There are no clear treatment guidelines for patients in whom complete surgical resection with curative intent is not possible. Acinar cell carcinomas are chemoresponsive to agents that have activity against pancreatic adenocarcinomas and colorectal carcinomas because of the shared genetic alterations between these cancers. The role of neoadjuvant or adjuvant chemoradiotherapy remains unproven. The aim of this article is to present current knowledge on acinar cell carcinoma and comprehensive review of available literature.

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“…7 Time-resolved immunofluorometric assay uses mouse monoclonal (MBPO405) capture and rabbit polyclonal (PBP0101) signal anti-PSA antibodies (Medix Biotech, Foster City, CA). Molecular size characterization analysis of this serum sample was performed.…”

Section: Serum Analysismentioning

confidence: 99%