Acne Vulgaris and Free Fatty Acids

Voss, J. G.

doi:10.1001/archderm.1974.01630060070020

Cited by 35 publications

(6 citation statements)

References 59 publications

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“…Cutaneous anaerobic and microaerophilic propionibacteria have been reported as facultative pathogenic organisms [1][2][3][4][5][6][7]. Particularly, in acne vulgaris lipase production by P. acnes has been regarded as a major etiological factor, releasing free fatty acids from sebum triglycerides [8][9][10]. The possible pathophysiological role of further enzymes and toxins has also been discussed [10,11 ].…”

Section: Introductionmentioning

confidence: 99%

“…Particularly, in acne vulgaris lipase production by P. acnes has been regarded as a major etiological factor, releasing free fatty acids from sebum triglycerides [8][9][10]. The possible pathophysiological role of further enzymes and toxins has also been discussed [10,11 ]. Among them production of neuraminidase (mucopolysacchandeoN-acetylneuraminylhydrolase, EC 3.2.1.18) and aldolase (acylneurammate pyruvate-lyase, EC 4.1.3.3) by P. acnes was first demonstrated by Muller [12].…”

Section: Introductionmentioning

confidence: 99%

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Neuraminidase production of Propionibacterium acnes and related bacteria

HOFFLER

1978

FEMS Microbiology Letters

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Neuraminidase production of Propionibacterium acnes and related bacteria

HOFFLER

1978

FEMS Microbiology Letters

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“…The authors proposed to reevaluate the role of free fatty acids in the pathogenesis of acne [78]. Voss [79] underlined the difficulty to say that changes caused by external application of great amounts of free fatty acids can be reproduced by the smaller amounts of free fatty acids liberated within the follicle.…”

Section: Seborrhea and Acne: Inseparable Players Of The Pathogenic Prmentioning

confidence: 99%

Acne Pathogenesis: History of Concepts

Tilles¹

2014

Dermatology

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From the first reliable descriptions of acne in the early 19th century, dermatologists recognized it as a disease of the pilosebaceous follicle. Until the middle of the 20th century, they hypothesized that seborrhoea, follicular keratosis and microorganisms could be individually responsible for the acne lesions. Inflammation was only regarded as the final and inescapable step of the acne process. Although the importance of these factors has been reevaluated, recent works still regarded them as mandatory. In the 1970s, the onset of isotretinoin dramatically improved acne management. It also provided great opportunities for a better understanding of the pathogenic factors of acne. This study analyzes their genesis and development from the seminal contributions until recent advances.

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“…The efficacy of tetracyclines was first related to the reduction of free fatty acid levels in sebum through direct inhibition of bacterial lipase activity (1-3) and to their bacteriostatic activity (4,5). In 1982, Leyden (6) endorsed this hypothesis to explain the efficacy of minocycline in tetracycline-resistant acnes (7).…”

Section: Introductionmentioning

confidence: 99%

Absence of Minocycline in Sebum?

Aubin

Blanc

Guinchard

et al. 1989

The Journal of Dermatology

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The authors studied the bioavailability of minocycline in sebum and serum. Blood and sebum samples were collected weekly for 6 weeks from ten healthy volunteers taking 200 mg of minocycline every day for 4 weeks. Sebum was collected by direct extraction with petroleum ether from the forehead. After evaporation, sebum was weighed on a scale accurate to 10 micrograms. Determination of minocycline in serum and sebum was performed using a high performance liquid chromatography technique (HPLC), with a better detection limit at 352 nm than at 400 nm (20 ng/ml and 0.324 microgram/ml respectively). Our results contrast with other studies since no minocycline was detected in the sebum samples of treated subjects and microbiological assays of minocycline in sebum were also negative. In our opinion, the current hypothesis claiming that the effectiveness of minocycline in the treatment of acne vulgaris is based on sebaceous secretion should be reconsidered.

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Acne Vulgaris and Free Fatty Acids

Cited by 35 publications

References 59 publications

Neuraminidase production of Propionibacterium acnes and related bacteria

Neuraminidase production of Propionibacterium acnes and related bacteria

Acne Pathogenesis: History of Concepts

Absence of Minocycline in Sebum?

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