BackgroundBrugada syndrome (SBr) is an arrhythmic condition characterized by ST-T
segment abnormalities in the right precordial leads associated with a high
risk of ventricular arrhythmias and sudden death. Local data regarding the
clinical characteristics of patients with a typical electrocardiographic
(ECG) pattern undergoing electrophysiological study are scarce.ObjectiveTo evaluate patients with an ECG pattern suggestive of SBr referred for
electrophysiological evaluation in a specialized center.MethodsCohort study of patients referred for electrophysiological study because of
an ECG pattern compatible with SBr between January 1998 and March 2017.ResultsOf the 5506 procedures, 35 (0.64%) were for SBr investigation, 25 of which
(71.42%) were performed in men. The mean age was 43.89 ± 13.1 years.
The ECG patterns were as follows: type I, 22 (62.85%); type II, 12 (34.30%);
and type III, 1 (2.85%). Twenty-three patients (65.7%) were asymptomatic, 6
(17.14%) had palpitations, 5 (14.3%) had syncope, and 3 (8.6%) had a family
history of sudden death. Electrophysiological study induced ventricular
tachyarrhythmias in 16 cases (45.7%), the mean ventricular refractory period
being 228 ± 36 ms. Ajmaline / procainamide was used in 11 cases
(31.4%), changing the ECG pattern to type I in 7 (63.6%). Sixteen cases
(45.7%) received an implantable cardioverter defibrillator (ICD). In a mean
5-year follow-up, 1 of the 16 patients (6.25%) with ICD had appropriate
therapy for ventricular fibrillation. There was no death. Other arrhythmias
occurred in 4 (11.4%) cases.ConclusionsMost patients are men, and a type I ECG pattern is the main indication for
electrophysiological study. Class IA drugs have a high ECG conversion rate.
The ICD event rate was 6%.