Acoustic radiation force elasticity imaging in diagnostic ultrasound

Doherty, Joshua R.; Trahey, Gregg E.; Nightingale, Kathryn R.; Palmeri, Mark L.

doi:10.1109/tuffc.2013.2617

Cited by 282 publications

(238 citation statements)

References 140 publications

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“…The speed of shear wave propagation (shear wave velocity [SWV], meters per second) is directly related to tissue elasticity and tissue stiffness. 16 The shear wave moves faster if the tissue is stiffer, whereas it moves slower if the tissue is softer.…”

mentioning

confidence: 99%

Shear Wave Elastography of the Spleen for Monitoring Transjugular Intrahepatic Portosystemic Shunt Function

Gao¹,

Xiao

Zheng

et al. 2016

J of Ultrasound Medicine

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A Pilot Studyhe transjugular intrahepatic portosystemic shunt (TIPS) is used for management of refractory acute variceal hemorrhage and intractable ascites in late-stage liver diseases with portal hypertension. 1 In addition to monitoring the clinical status, it is important to monitor TIPS hemodynamic function objectively. 2,3 Although the portosystemic pressure gradient (PPG) and hepatic venous pressure gradient are still considered the reference standards for diagnosis and monitoring of portal hypertension, they Jing Gao, MD, Xiao Zheng, MS, Yuan-Yi Zheng, MD, Guo-Qing Zuo, MD, Hai-Tao Ran, MD, Yong Ho Auh, MD, Levi Waldron, PhD, Tiffany Chan, MS, Zhi-Gang Wang, MD Received July 6, 2015, Objectives-To assess the feasibility of splenic shear wave elastography in monitoring transjugular intrahepatic portosystemic shunt (TIPS) function.Methods-We measured splenic shear wave velocity (SWV), main portal vein velocity (PVV), and splenic vein velocity (SVV) in 33 patients 1 day before and 3 days to 12 months after TIPS placement. We also measured PVV, SVV, and SWV in 10 of 33 patients with TIPS dysfunction 1 day before and 3 to 6 days after TIPS revision. Analyses included differences in portosystemic pressure gradient (PPG), PVV, SVV, and mean SWV before and after TIPS procedures; comparison of median SWV before and after TIPS procedures; differences in PVV, SVV, and SWV before and at different times up to 12 months after TIPS placement; accuracy of PVV, SVV, and SWV in determining TIPS dysfunction; and correlation between PPG and SWV.Results-During 12 months of follow-up, 23 of 33 patients had functioning TIPS, and 10 had TIPS dysfunction. The median SWV was significantly different before and after primary TIPS placement (3.60 versus 3.05 m/s; P = .005), as well as before and after revision (3.73 versus 3.06 m/s; P = .003). The PPG, PVV, and SVV were also significantly different before and after TIPS placement and revision (P < .001). The PPG and SWV decreased, whereas PVV and SVV increased, after successful TIPS procedures. A positive correlation was observed between PPG and SWV (r = 0.70; P < .001), and a negative correlation was observed between PPG and PVV and SVV (r = -0.65; P < .001). The areas under the receiver operating characteristic curve for PVV, SVV, and SWV in determining TIPS dysfunction were 0.82, 0.84, and 0.81, respectively.Conclusions-Splenic SWV is compatible with splenoportal venous velocity in quantitatively monitoring TIPS function and determining TIPS dysfunction.

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mentioning

confidence: 99%

Shear Wave Elastography of the Spleen for Monitoring Transjugular Intrahepatic Portosystemic Shunt Function

Gao¹,

Xiao

Zheng

et al. 2016

J of Ultrasound Medicine

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“…This equation may be solved for f x ¼ nk s /2p, the detected cycles per unit length, where the additional factor of n is due to the spatial frequency multiplication in Eq. (10). The resulting expressions for f x are…”

Section: Swipe Lateral Spatial Frequency Response Under Constraintsmentioning

confidence: 99%

“…7 This property enables the wide variety of shear wave elasticity imaging methods. [8][9][10] It is likely that there are additional useful combinations of multiple wave types for imaging. 11 We have recently presented a method in which lateral resolution of the target is obtained by using traveling shear waves to encode the lateral position of the scatters in the phase of the received echo.…”

Section: Introductionmentioning

confidence: 99%

Analysis and measurement of the modulation transfer function of harmonic shear wave induced phase encoding imaging

McAleavey

2014

The Journal of the Acoustical Society of America

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Shear wave induced phase encoding (SWIPE) imaging generates ultrasound backscatter images of tissue-like elastic materials by using traveling shear waves to encode the lateral position of the scatters in the phase of the received echo. In contrast to conventional ultrasound B-scan imaging, SWIPE offers the potential advantages of image formation without beam focusing or steering from a single transducer element, lateral resolution independent of aperture size, and the potential to achieve relatively high lateral resolution with low frequency ultrasound. Here a Fourier series description of the phase modulated echo signal is developed, demonstrating that echo harmonics at multiples of the shear wave frequency reveal target k-space data at identical multiples of the shear wavenumber. Modulation transfer functions of SWIPE imaging systems are calculated for maximum shear wave acceleration and maximum shear constraints, and compared with a conventionally focused aperture. The relative signal-to-noise ratio of the SWIPE method versus a conventionally focused aperture is found through these calculations. Reconstructions of wire targets in a gelatin phantom using 1 and 3.5 MHz ultrasound and a cylindrical shear wave source are presented, generated from the fundamental and second harmonic of the shear wave modulation frequency, demonstrating weak dependence of lateral resolution with ultrasound frequency.

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“…Initially, shear waves were generated with a transient vibration originating from an external mechanical vibrator [3,4]. However, as these vibrators were challenging to integrate in daily clinical practice, the excitation source was changed into a remote palpation induced by a radiation force of focused ultrasonic beam(s), unifying the shear wave excitation source and ultrafast imaging modality together in the ultrasound transducer [5,[7][8][9]. At the beginning, the ultrafast frame rates came at the cost of reduced image contrast and resolution compared to conventional transmissions as the transmit focusing step is skipped in the ultrafast imaging modality.…”

Section: Introductionmentioning

confidence: 99%

Effect of Ultrafast Imaging on Shear Wave Visualization and Characterization: An Experimental and Computational Study in a Pediatric Ventricular Model

et al. 2017

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Plane wave imaging in Shear Wave Elastography (SWE) captures shear wave propagation in real-time at ultrafast frame rates. To assess the capability of this technique in accurately visualizing the underlying shear wave mechanics, this work presents a multiphysics modeling approach providing access to the true biomechanical wave propagation behind the virtual image. This methodology was applied to a pediatric ventricular model, a setting shown to induce complex shear wave propagation due to geometry. Phantom experiments are conducted in support of the simulations. The model revealed that plane wave imaging altered the visualization of the shear wave pattern in the time (broadened front and negatively biased velocity estimates) and frequency domain (shifted and/or decreased signal frequency content). Furthermore, coherent plane wave compounding (effective frame rate of 2.3 kHz) altered the visual appearance of shear wave dispersion in both the experiment and model. This mainly affected stiffness characterization based on group speed, whereas phase velocity analysis provided a more accurate and robust stiffness estimate independent of the use of the compounding technique. This paper thus presents a versatile and flexible simulation environment to identify potential pitfalls in accurately capturing shear wave propagation in dispersive settings.

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Acoustic radiation force elasticity imaging in diagnostic ultrasound

Cited by 282 publications

References 140 publications

Shear Wave Elastography of the Spleen for Monitoring Transjugular Intrahepatic Portosystemic Shunt Function

Shear Wave Elastography of the Spleen for Monitoring Transjugular Intrahepatic Portosystemic Shunt Function

Analysis and measurement of the modulation transfer function of harmonic shear wave induced phase encoding imaging

Effect of Ultrafast Imaging on Shear Wave Visualization and Characterization: An Experimental and Computational Study in a Pediatric Ventricular Model

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