Acquired cold urticaria symptoms can be safely prevented by ebastine

Włodarczyk

J Neurogastroenterol Motil

et al. 2017

Irritable bowel syndrome is a group of functional gastrointestinal disorders with not yet fully clarified etiology. Recent evidence suggesting that mast cells may play a central role in the pathogenesis of irritable bowel syndrome paves the way for agents targeting histamine receptors as a potential therapeutic option in clinical treatment. In this review, the role of histamine and histamine receptors is debated. Moreover, the clinical evidence of anti-histamine therapeutics in irritable bowel syndrome is discussed.

Section: Possible Application Of Anti-histamine Drugs In Irritable Bomentioning

confidence: 99%

Targeting Histamine Receptors in Irritable Bowel Syndrome: A Critical Appraisal

Włodarczyk

J Neurogastroenterol Motil

et al. 2017

A Comprehensive Review of Urticaria and Angioedema

“…Siebenhaar et al claimed that high dose of desloratadine is better in controlling CCU when compared with the standard dose [37]. Likewise, Magerl et al reported that H1 antihistamine up-dosing increases the success rate in the treatment of CCU [38].…”

Section: Len)/mentioning

confidence: 99%

Chronic Inducible Urticaria: Part II

Borlu¹,

Çınar²,

Kartal³

2017

Physical urticaria (PU) is a subgroup of acquired, chronic inducible urticaria which is associated with a known physical trigger. In PU, the symptoms are induced by exogenous physical triggers, such as friction, pressure, vibration, cold, heat, or solar radiation. All the PUs may manifest with both wheals and angioedema at the sites of the triggers with the exceptions that urticaria factitia (UF) (symptomatic dermatographism) presents with wheals only and pressure urticaria presents with angioedema only. More than one form of physically induced urticarias can be present in one patient.

“…Hier nehmen nicht sedierende Antihistaminika eine zentrale Rolle ein. Diese haben sich in verschiedenen Studien als effektiv und gut verträglich in der Therapie der Kältekontakturtika-ria erwiesen [9,11,21,33,39,51] und werden von den internationalen EAACI/GA-2 LEN/EDF/WAO-Leitlinien als Standardtherapie empfohlen [61]. …”

Section: Kältekontakturtikariaunclassified

Kälteinduzierte Quaddeln und Angioödeme

et al. 2010

Self Cite

The onset of wheals and/or angioedema following the exposure to cold may be associated with a number of different diseases. Most frequently this occurs in cold contact urticaria, a type of physical urticaria, which is characterized by a positive cold stimulation test. The clinical symptoms are based on cold-dependent mast cell activation with subsequent release of proinflammatory mediators. In cases of negative or atypical reaction to cold stimulation testing rare acquired atypical or familiar cold urticaria forms may be suspected. Strict avoidance of cold should be recommended as far as possible. As the underlying causes of cold contact urticaria are widely unknown, the symptomatic use of non-sedating antihistamines is the treatment of first choice. The very rare familiar cold auto-inflammatory syndrome (FCAS) is based on CIAS1/NLRP3 mutations and may be treated effectively by neutralization of pathogenic interleukin 1beta.