2022
DOI: 10.3390/foods11111590
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Acrolein Promotes Aging and Oxidative Stress via the Stress Response Factor DAF-16/FOXO in Caenorhabditis elegans

Abstract: For this investigation, Caenorhabditis elegans (C. elegans) served, for the first time, as a model organism to evaluate the toxic effect and possible underlying mechanisms under acrolein (ACR) exposure. The results showed that ACR exposure (12.5–100 μM) shortened the lifespan of C. elegans. The reproductive capacity, body length, body width, and locomotive behavior (head thrash) of C. elegans were diminished by ACR, especially the doses of 50 and 100 μM. Furthermore, ACR significantly enhanced the endogenous R… Show more

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Cited by 13 publications
(12 citation statements)
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“…The theoretical basis for the toxic effects of acrolein and its potential mechanism of oxidative stress induction is provided by a recent study on Caenorhabditis elegans by Hong et al [ 89 ]. Excessive acrolein-dependent production of ROS is associated with a decrease in the activity of ROS scavenging enzyme superoxide dismutase (SOD) and catalase (CAT) and concomitant activation of oxidative-stress-related pathways DAF-16/FOXO.…”
Section: Acrolein Is One Of the Main Risk Factors For Chronic Obstruc...mentioning
confidence: 99%
See 1 more Smart Citation
“…The theoretical basis for the toxic effects of acrolein and its potential mechanism of oxidative stress induction is provided by a recent study on Caenorhabditis elegans by Hong et al [ 89 ]. Excessive acrolein-dependent production of ROS is associated with a decrease in the activity of ROS scavenging enzyme superoxide dismutase (SOD) and catalase (CAT) and concomitant activation of oxidative-stress-related pathways DAF-16/FOXO.…”
Section: Acrolein Is One Of the Main Risk Factors For Chronic Obstruc...mentioning
confidence: 99%
“…Excessive acrolein-dependent production of ROS is associated with a decrease in the activity of ROS scavenging enzyme superoxide dismutase (SOD) and catalase (CAT) and concomitant activation of oxidative-stress-related pathways DAF-16/FOXO. The research undoubtedly contributed to enriching the toxicological evaluation of acrolein [ 89 ].…”
Section: Acrolein Is One Of the Main Risk Factors For Chronic Obstruc...mentioning
confidence: 99%
“…Oxygen radicals generated by ROS are normal products of cellular metabolism and are “double-edged swords” within the cell [ 47 , 48 , 49 ]. During cellular stress and injury, the cell response is regulated by some levels of superoxide dismutase (SOD), glutathione (GSH), and vitamins through enzymatic and non-enzymatic reactions, and these can reduce the production of ROS [ 50 ].…”
Section: Resultsmentioning
confidence: 99%
“…To measure changes in nematode body length, nematodes treated with or without 1 × 10 7 particles/ml dauer EVs were photographed on 2% agar after anesthesia on days 5, 8, and 11, and their body length was quantified using ImageJ (Hong et al 2022 ). The experiment was repeated three times independently with at least 20 nematodes in each group.…”
Section: Methodsmentioning
confidence: 99%