ACTH and Grooming Behaviour in the Rat

Spruijt, Berry M.; Gispen, W.H.

doi:10.1007/978-3-642-69216-1_9

Cited by 8 publications

(3 citation statements)

References 85 publications

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“…Self-grooming is primarily mediated centrally by ACTH and CRF (Dunn, Berridge, Lai, Yachabach, & File, 1988;Spruijt & Gispen, 1983); other stress-mediating peptides such as oxytocin, prolactin, endorphins, and vasopressin modulate this system (Colbern & Gispen, 1988;Dunn, 1988). Both behaviors are influenced by anxiolytic and anxiogenic drugs in directions consistent with hypotheses that they reflect anxiety (File, 1992).…”

Section: Discussionmentioning

confidence: 65%

Development of ultrasonic vocalization responses in genetically heterogeneous National Institute of Health (N:NIH) rats. II. Associations among variables and behaviors

Brunelli

Hofer

1996

Dev. Psychobiol.

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Section: Discussionmentioning

confidence: 65%

Development of ultrasonic vocalization responses in genetically heterogeneous National Institute of Health (N:NIH) rats. II. Associations among variables and behaviors

Brunelli

Hofer

1996

Dev. Psychobiol.

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“…ACTH induces excessive grooming in which the various grooming elements are more or less equally involved (Gispen and Isaacson, 1981;Spruijt and Gispen, 1983;Van Wimersma Greidanus et al, 1985a;in press) whereas the excessive grooming induced by bombesin is completely different, with excessive scratching as the most pronounced element (Van Wimersma Greidanus et al, 1985a,b;Spruijt et al, 1986b). fl-Endorphin-induced excessive grooming is also characterized by a predominant display of scratching (Aloyo et al, 1983;Spruijt et al, 1986a;Van Wimersma Greidanus et al, in press).…”

Section: Introductionmentioning

confidence: 99%

Excessive grooming induced by somatostatin or its analog SMS 201-995

Greidanus

Maigret

Krechting

1987

European Journal of Pharmacology

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Intracerebroventricular (i.c.v.) administration of somatostatin or SMS 201-995 induces excessive grooming behavior in rats. The grooming inducing effect of somatostatin is rather weak, as doses of 300 ng or less did not result in increased total grooming scores. In contrast a dose of 10 ng SMS 201-995 already significantly increased the total grooming scores. However, doses of 100 ng and more did not further increase the total grooming scores reached with a 50 ng dose of this peptide. Systemic administration of SMS 201-995 in doses up to 900 ~tg did not result in excessive grooming behavior. Fhe patterns of excessive grooming induced by i.c.v. SMS 201-995 and somatostatin were characterized by a predominant display of scratching. Since peptide-induced scratching is mainly due to activation of opiate receptor systems it is suggested that opiate receptors are involved in the behavioral response to SMS 201-995 and somatostatin administration. This suggestion is further supported by the suppressive effect of naloxone on excessive grooming induced by these peptides. Haloperidol and neurotensin also suppress the excessive grooming induced by somatostatin but not that induced by SMS 201-995. Finally, tolerance developed to the grooming-inducing effect of SMS 201-995 and somatostatin. In addition there was cross tolerance between somatostatin and SMS 201-995.Somatostatin; SMS 201-995; Grooming behavior

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“…Self-grooming in response to novelty was initially observed by Bindra and Spinner (1958) and by Bolles (1960). Subsequently, the experimental demonstration that exogenous or endogenous adrenocorticotropic hormone also induces excessive self-grooming behavior (for reviews see Gispen & Isaacson, 1981; Spruijt & Gispen, 1983) stimulated broad research efforts to identify hormone, drug, and neurotransmitter interactions that affect the self-grooming response (for a recent and comprehensive overview see Colbern & Gispen, 1988).…”

mentioning

confidence: 99%

Sex differences in investigatory and grooming behaviors of laboratory rats (Rattus norvegicus) following exposure to novelty.

Thor¹,

Harrison²,

Schneider³

et al. 1988

Journal of Comparative Psychology

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Prior research suggested that during exposure to novel stimuli, rodent investigation and self-grooming behaviors may be sexually dimorphic and interact with ambient illumination. To test this notion we compared the behavior of adult male and female groups of Long-Evans hooded rats in normal room lighting (860 lx) and in very dim, red light (0.2 lx) following exposure to a novel juvenile conspecific. Illuminance level had little or no effect, but investigatory and subsequent self-grooming behaviors of males were substantially greater than those of females, and females engaged in greater ambulatory activity than did males. In a second experiment adult males and females were exposed to a novel inanimate object. No reliable sex differences were observed. We conclude that social novelty, as provided by exposure to a juvenile conspecific, stimulates greater investigation and postinvestigatory self-grooming than exposure to a novel inanimate object and that exposure to novel conspecifics presents a useful method for the investigation of sex differences, gonadal hormone effects, and interactions of hormones with neurotransmitter systems governing motor control systems.

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ACTH and Grooming Behaviour in the Rat

Cited by 8 publications

References 85 publications

Development of ultrasonic vocalization responses in genetically heterogeneous National Institute of Health (N:NIH) rats. II. Associations among variables and behaviors

Development of ultrasonic vocalization responses in genetically heterogeneous National Institute of Health (N:NIH) rats. II. Associations among variables and behaviors

Excessive grooming induced by somatostatin or its analog SMS 201-995

Sex differences in investigatory and grooming behaviors of laboratory rats (Rattus norvegicus) following exposure to novelty.

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