Action of histamine on eustachian tube function

Downs, Brian W.; Butehorn, Henry F.; Prazma, Jiri; Rose, Austin S.; Stamat, Jocelyn C.; Pillsbury, Harold C.

doi:10.1067/mhn.2001.113943

Cited by 31 publications

(28 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Various murine studies have supported this theory, demonstrating the role of allergen‐induced inflammation in eustachian tube abnormalities. Downs et al demonstrated that transtympanic exposure to histamine resulted in ETD. Hardy et al showed that late‐stage, allergen‐induced inflammation of sensitized rats’ middle ears led to ETD and subsequent effusion.…”

Section: Discussionmentioning

confidence: 99%

Sinonasal risk factors for eustachian tube dysfunction: Cross‐sectional findings from NHANES 2011‐2012

Juszczak¹,

Aubin-Pouliot

Sharon

et al. 2019

Int Forum Allergy Rhinol

View full text Add to dashboard Cite

Background: Sinonasal pathology is frequently cited as a cause of eustachian tube dysfunction (ETD), despite a lack of evidence. Using a large, nationally representative sample, we investigated whether abnormal tympanometry, an objective marker of ETD, was associated with infectious, allergic, and exposure-related sinonasal risk factors. Methods:Relevant data were extracted from the 2011-2012 National Health and Nutrition Examination Survey (NHANES). Tympanometric types (A, B, and C) were determined using peak pressure and compliance values. Participants with a type B or C tympanogram in at least one ear were classified as having ETD. Demographic and clinicopathologic risk factors with putative associations with ETD were determined. Statistical analysis, including regression modeling, was performed using Stata (version 15.1) to determine the correlation between sinonasal factors and ETD. Results:The final analysis included 1253 subjects and 19 variables. We controlled for demographic data including age, gender, race, and income. In both univariate and multivariate logistic regression, statistically significant correlations were found between abnormal tympanometric values and: (1) having a persistent cold/flu in the last 12 months (univariate: adjusted odds ratio [OR], 2.42; p = 0.006; multivariate: adjusted OR, 2.15; p = 0.006); and (2) experiencing "hay fever" (ie, allergic rhinitis) within the last 12 months (univariate: adjusted OR, 1.95; p = 0.021; multivariate: adjusted OR, 1.71; p = 0.039). Conclusion:Using a large, representative data set, we identified significant correlations between ETD and (1) persistent cold/flu symptoms and (2) self-reported allergic rhinitis. C 2019 ARS-AAOA, LLC.

show abstract

Section: Discussionmentioning

confidence: 99%

Sinonasal risk factors for eustachian tube dysfunction: Cross‐sectional findings from NHANES 2011‐2012

Juszczak¹,

Aubin-Pouliot

Sharon

et al. 2019

Int Forum Allergy Rhinol

View full text Add to dashboard Cite

show abstract

“…This is despite extensive research into animal models for eustachian tube dysfunction. 45,46,81,83,87,[96][97][98][99][100][101][102][103][104][105][106][107][108][109][110] One study demonstrated a role for the eustachian tube in tympanic membrane healing. 3 Blockage of the eustachian tube did not cause delayed closure of pars tensa perforations when the two procedures were performed at the same time.…”

Section: Discussionmentioning

confidence: 99%

Chronic tympanic membrane perforation: a better animal model is needed

Maria

Atlas

Ghassemifar

2007

Wound Repair Regeneration

View full text Add to dashboard Cite

Developments in the treatment of chronic tympanic membrane perforation have been hindered by the lack of an ideal animal model. It is not appropriate to test such treatments on acute perforations as the majority of these heal spontaneously. An ideal animal model would be one that most closely resembles the human clinical situation. It should be inexpensive, readily available, and easy to create. There have been a number of attempts to create a chronic tympanic membrane perforation model with limited success. All published attempts at chronic tympanic membrane perforations have been reviewed and the limitations of each model are discussed. A number of areas for research exist for further developing a chronic tympanic membrane perforation model. These areas include a perforation model in the presence of bacteria and eustachian tube dysfunction. Understanding the molecular and genetic mechanisms of chronic otitis media and potential treatments will also be useful.

show abstract

“…Data from several animal studies have suggested a link between nasal allergic inflammation and ET dysfunction. For example, an intranasal pollen antigen challenge significantly compromised ET function in 23 passively sensitized juvenile rhesus monkeys (24), while a histamine challenge impeded the clearance and pressure‐mediating functions of the ET in rats (25). A nasal allergen challenge in rats resulted in ET inflammation, negative pressure, and hindrance of mucociliary clearance that was mitigated by pretreatment with immune modulatory oligonucleotides (26).…”

Section: Pathophysiology Of Ome and Armentioning

confidence: 99%

“…The frequency of OME in British preschool children was reported from participants in the Avon Longitudinal Study of Pregnancy and Childhood (ALSPAC). Midgley et al selected a random sample of children (10%, n = 1400) who were examined at 8,12,18,25,31,37,43,49, and 61 months. Sex had no effect, but there was a decrease in prevalence of OME with increasing age and a marked seasonal effect on the frequency of OME.…”

Section: Epidemiology: Ome and Atopymentioning

confidence: 99%

The link between otitis media with effusion and allergy: A potential role for intranasal corticosteroids

Lack

Caulfield

Penagos

2011

Pediatric Allergy Immunology

View full text Add to dashboard Cite

We reviewed the evidence linking otitis media with effusion (OME) and atopy, with the goal of clarifying the possible role of intranasal corticosteroids (INSs) in OME treatment. In August 2009, the MEDLINE database was searched for primary studies on OME epidemiology, pathophysiology, and treatment. Relevant clinical guidelines were obtained. Interpreting OME research is complicated by variable disease definitions, patient populations, methodologies, and outcomes assessments, along with the possibility of spontaneous resolution. However, evidence links OME with atopic conditions including allergic rhinitis; observed prevalence of allergic rhinitis in patients with chronic or recurrent OME ranges from 24% to 89%. Such findings have prompted evaluations of common allergy medications for OME treatment. While short-term use of INSs alone or combined with antibiotics has shown benefit in some studies, more prolonged treatment protocols and long-term clinical outcomes will require critical assessment. Evidence suggesting epidemiologic and pathophysiologic links between allergy and OME has prompted investigation into a potential role for INSs in OME management, with promising initial results. Benefits of considering medical treatment in patients with OME prior to surgery include both the potential reductions in allergic inflammation and the naturally occurring spontaneous resolution of OME in these patients.

show abstract

Action of histamine on eustachian tube function

Abstract: Transtympanic histamine exposure causes eustachian tube dysfunction in the rat by increasing passive opening and closing pressures of the eustachian tube and impairing mucociliary clearance time.

Cited by 31 publications

References 24 publications

Sinonasal risk factors for eustachian tube dysfunction: Cross‐sectional findings from NHANES 2011‐2012

Sinonasal risk factors for eustachian tube dysfunction: Cross‐sectional findings from NHANES 2011‐2012

Chronic tympanic membrane perforation: a better animal model is needed

The link between otitis media with effusion and allergy: A potential role for intranasal corticosteroids

Contact Info

Product

Resources

About