Actions of Cardiac Glycosides on the Vessels of the Forearm and Hand

Glover, W. E.; Hanna, M. J. D.; Speden, R. N.

doi:10.1093/cvr/1.4.341

Cited by 7 publications

(5 citation statements)

References 16 publications

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“…The acute intravenous administration of the digitalis glycosides digoxin or ouabain caused either a small and transient increase in blood pressure [19,20] or had no effect on blood pressure [21,22]. The acute intravenous administration of the digitalis glycosides digoxin or ouabain caused either a small and transient increase in blood pressure [19,20] or had no effect on blood pressure [21,22].…”

Section: Discussionmentioning

confidence: 99%

“…Correspondingly, disparate reports on the acute and chronic effects of digitalis glycosides on blood pressure in healthy subjects and in patients with heart disease have been published. The acute intravenous administration of the digitalis glycosides digoxin or ouabain caused either a small and transient increase in blood pressure [19,20] or had no effect on blood pressure [21,22]. Chronic administration of digoxin had no effect on casual blood pressure measurements in normal subjects [23,24] or caused a slight increase in systolic blood pressure without effects on dynamic exercise [25].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Effects of digoxin and digitoxin on circadian blood pressure profile in healthy volunteers

Großmann

Jamieson

Kirch

1998

Eur J Clin Investigation

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Effects of digoxin and digitoxin on circadian blood pressure profile in healthy volunteers

Großmann

Jamieson

Kirch

1998

Eur J Clin Investigation

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“…Some investigators (4,6,7) found evidence for a direct venoconstrictor effect of digitalis glycosides, but this was not confirmed by other workers (5,8).…”

Section: Additional Abstract Acetylstrophanthidin and Veins Digoxin mentioning

confidence: 89%

“…• Although there is agreement that digitalis glycosides have a direct constrictor effect on resistance vessels of the systemic circulation (1)(2)(3)(4)(5), opinions differ on the action of these drugs on veins. Some investigators (4,6,7) found evidence for a direct venoconstrictor effect of digitalis glycosides, but this was not confirmed by other workers (5,8).…”

Section: Additional Abstract Acetylstrophanthidin and Veins Digoxin mentioning

confidence: 99%

Potentiation of Adrenergic Venomotor Responses in Dogs by Cardiac Glycosides

Brender

Vanhoutte

Shepherd

1969

Circulation Research

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Acetylstrophanthidin, 0.3 to 10 /xg/ml, caused contraction of helical strips of the dog cutaneous vein in an organ bath at 37°C. A latent period of 12 to 60 minutes preceded the contraction. During this time, the vein exhibited a progressive increase in response to transmural electric stimulation and added norepinephrine. As the dose of acetylstrophanthidin was increased, the latent period shortened and the increased response during the latent period was potentiated. When the contraction caused by 10 /xg/ml was maximal, no additional contraction occurred with electric stimulation; the response to electric stimulation was only partially restored by the repeated washing out of the drug, despite relaxation of the strip to almost base-line tension. Since transmural electric stimulation causes contraction by release of tissue catecholamines, these experiments demonstrate that digitalis glycosides sensitize the cutaneous veins of the dog to adrenergic stimulation. This was confirmed in dogs anesthetized with pentobarbital. Intravenous injections of acetylstrophanthidin and digoxin, in doses too small (12.5 to 15.5 /xg/kg) to cause direct constriction of the lateral saphenous vein, potentiated the constriction of this vein caused by electric stimulation of the lumbar sympathetic chain.

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“…Furthermore, altered fluid shifts cannot explain the unchanged [K + ] with digoxin, since arterio‐venous ΔPV or ΔBV were unchanged by digoxin, in both FF or LC trials. Early studies in healthy males found that intravenous ouabain infusion of 0.05 mg min −1 for 10 min did not affect forearm or hand blood flow (Glover et al., 1967). We found slightly lower forearm blood flow during FF with digoxin, but this seems unlikely to explain the lack of effect of digoxin on the [K + ] a‐v and K + fluxes during FF.…”

Section: Discussionmentioning

confidence: 99%

Oral digoxin effects on exercise performance, K⁺ regulation and skeletal muscle Na⁺,K⁺‐ATPase in healthy humans

Sostaric

Petersen

Goodman

et al. 2022

The Journal of Physiology

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We investigated whether digoxin lowered muscle Na + ,K + -ATPase (NKA), impaired muscle performance and exacerbated exercise K + disturbances. Ten healthy adults ingested digoxin (0.25 mg; DIG) or placebo (CON) for 14 days and performed quadriceps strength and fatiguability, finger flexion (FF, 105% peak-workrate , 3 × 1 min, fourth bout to fatigue) and leg cycling (LC, 10 min at 33% V O 2 peak and 67% V O 2 peak , 90% V O 2 peak to fatigue) trials using a double-blind, crossover, randomised, counter-balanced design. Arterial (a) and antecubital venous (v) blood was sampled (FF, LC) and muscle biopsied (LC, rest, 67% V O 2 peak , fatigue, 3 h after exercise). In DIG, in resting muscle, [ 3 H]-ouabain binding site content (OB-F ab ) was unchanged; however, bound-digoxin removal with Digibind revealed total ouabain binding (OB+F ab ) increased (8.2%, P = 0.047), indicating 7.6% NKA-digoxin occupancy. Quadriceps muscle strength declined in DIG (−4.3%, P = 0.010) but fatiguability was unchanged. During LC, in DIG (main effects), time to fatigue and [K + ] a were unchanged, whilst [K + ] v was lower (P = 0.042) and [K + ] a-v greater (P = 0.004) than in CON; with exercise (main effects), muscle OB-F ab was increased at 67% V O 2 peak (per wet-weight, P = 0.005; per protein P = 0.001) and at fatigue (per protein, P = 0.003), whilst [K + ] a , [K + ] v and [K + ] a-v were each increased at fatigue (P = 0.001). During FF, in DIG (main effects), time to fatigue, [K + ] a , [K + ] v and [K + ] a-v were unchanged; with exercise (main effects), plasma [K + ] a , [K + ] v , [K + ] a-v and muscle K + efflux were all increased at fatigue (P = 0.001). Thus, muscle strength declined, but functional muscle NKA content was preserved during DIG, despite elevated plasma digoxin and muscle NKA-digoxin occupancy, with K + disturbances and fatiguability unchanged.

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Actions of Cardiac Glycosides on the Vessels of the Forearm and Hand

Cited by 7 publications

References 16 publications

Effects of digoxin and digitoxin on circadian blood pressure profile in healthy volunteers

Effects of digoxin and digitoxin on circadian blood pressure profile in healthy volunteers

Potentiation of Adrenergic Venomotor Responses in Dogs by Cardiac Glycosides

Oral digoxin effects on exercise performance, K⁺ regulation and skeletal muscle Na⁺,K⁺‐ATPase in healthy humans

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Actions of Cardiac Glycosides on the Vessels of the Forearm and Hand

Cited by 7 publications

References 16 publications

Effects of digoxin and digitoxin on circadian blood pressure profile in healthy volunteers

Effects of digoxin and digitoxin on circadian blood pressure profile in healthy volunteers

Potentiation of Adrenergic Venomotor Responses in Dogs by Cardiac Glycosides

Oral digoxin effects on exercise performance, K+ regulation and skeletal muscle Na+,K+‐ATPase in healthy humans

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Product

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Oral digoxin effects on exercise performance, K⁺ regulation and skeletal muscle Na⁺,K⁺‐ATPase in healthy humans