Effects of digoxin and digitoxin on circadian blood pressure profile in healthy volunteers

Abstract

Both digoxin and digitoxin, within therapeutic steady-state plasma concentrations, reduced diastolic blood pressure and heart rate during overnight sleep, presumably because of increased parasympathetic activity or decreased sympathetic activity.

Selective association of endogenous ouabain with subclinical organ damage in treated hypertensive patients

“…Endogenous ouabain and organ damage G Nagy et al patients with heart failure treated by exogenous cardiac glycoside presuming an elevated sympathetic tone in this population. [18][19][20] In our study, the excreted level of norepinephrine assessed in morning fresh urine, positively correlates with urinary level of EO. These observations support the theory that the level of plasma EO may have a regulatory role in nighttime blood pressure profile, probably with increased sympathetic activation in hypertensive patients untreated with cardiac glycosides.…”

“…17 The orally administered cardiac glycoside (digoxin) in the therapeutic range decreased the nighttime diastolic blood pressure in healthy volunteers as well as it had in patients with heart failure a diminishing effect on the nighttime diastolic blood pressure and elevated the nighttime systolic blood pressure but it did not have an effect on daytime blood pressure profile because it is overregulated by sympathetic effects of daytime activities. [18][19][20] Production of EDLF in humans is not constant; a decreased nighttime urinary EDLF excretion has been shown in healthy volunteers. 21 Our goal was to analyse associations between plasma and urinary EO and several markers of cardiovascular status including results of echocardiography, echo-tracking and ABPM as well as other parameters as brain natriuretic peptide (BNP), nighttime catecholamines excretion, intima-media thickness (IMT) in patients with treated primary hypertension (HT), type 2 diabetes mellitus (DM) and/or chronic kidney disease (CKD).…”

Effect of digoxin on circadian blood pressure values in patients with congestive heart failure

“…In healthy normotensive subjects we found a significant negative chronotropic effect of cardiac glycosides compared to placebo [7]. In healthy normotensive subjects we found a significant negative chronotropic effect of cardiac glycosides compared to placebo [7].…”

Effects of cardiac glycosides on 24‐h ambulatory blood pressure in healthy volunteers and patients with heart failure

“…In two randomized double‐blind, placebo‐controlled cross‐over protocols, we studied 12 healthy normotensive subjects (24 ± 2 years old, 70 ± 10 kg body weight) in either study [4]. The subjects were screened to be normotensive by three consecutive sphygmomanometric blood‐pressure measurements (systolic pressure, 121 ± 8 mmHg; diastolic pressure, 77 ± 7 mmHg).…”