Activation of hypoxia-inducible factor-1 regulates human histidine decarboxylase expression

Jeong, Hyun‐Ja; Moon, Phil‐Dong; Kim, S. J.; Seo, Jae-Uk; Kang, Taehee; Kim, J. J.; Kang, In‐Cheol; Um, Jae‐Young; Kim, H. M.; Hong, Seung‐Heon

doi:10.1007/s00018-009-9001-1

Cited by 45 publications

(37 citation statements)

References 32 publications

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“…It is supposed that hypoxia might be an important factor to induce muscle fatigue. Indeed, a recent report has demonstrated that hypoxia-inducible factor-1 (HIF) has an HDC-inducing activity, 34) suggesting that the less PW-endurance of H1-KO mice might be due to a larger production of HIF due to hypoxia. Collectively, the results obtained by the present study may also support the idea that (i) histamine or HDC induction may be important to reduce exercise-induced fatigue as a protective mechanism, and (ii) mice with a lower PW-endurance may need more HDC induction against hypoxia due to PW.…”

Section: Discussionmentioning

confidence: 99%

Roles of Histamine in Exercise-Induced Fatigue: Favouring Endurance and Protecting against Exhaustion

Yaoita

Tsuchiya

Ohtsu

et al. 2012

Biological & Pharmaceutical Bulletin

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Exercise necessitates a large supply of O 2 and nutrients and rapid removal of CO 2 and waste products. Histamine is a regulator of the microcirculation (which performs these exchanges), suggesting a possible involvement of histamine in exercise. Histamine is released from either mast cells or non-mast cells. In the latter, histamine is newly formed via the induction of histidine decarboxylase (HDC) in response to an appropriate stimulus, and it is released without being stored. Here, in mice, we examined the role of histamine or HDC induction in exercise. Prolonged walking (PW) (in a cylindrical cage turned electrically) increased HDC mRNA and HDC activity in quadriceps femoris muscles. Mice given a histamine H1-receptor antagonist [fexofenadine (peripherally acting) or pyrilamine (peripherally and centrally acting)] or an irreversible HDC inhibitor (α-fluoromethylhistidine) displayed less PW endurance than control mice. Ranitidine (H2-receptor antagonist) tended to reduce endurance. Other histamine-receptor (H3 and H4) antagonists had no significant effects on endurance. Mice deficient in HDC or histamine H1-receptors displayed markedly less endurance than control mice, and HDC activity in the quadriceps femoris of H1-deficient mice was rapidly elevated by PW. Fexofenadine significantly reduced the muscle levels of nitric oxide (NO) metabolites and glycogen after PW. The results support the ideas that (i) histamine is involved in protecting against exerciseinduced fatigue or exhaustion, (ii) histamine exerts its protective effect via H1 receptors and the ensuing production of NO in skeletal muscle, and (iii) histamine is provided, at least in part, by HDC induction in skeletal muscles during prolonged exercise.

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Section: Discussionmentioning

confidence: 99%

Roles of Histamine in Exercise-Induced Fatigue: Favouring Endurance and Protecting against Exhaustion

Yaoita

Tsuchiya

Ohtsu

et al. 2012

Biological & Pharmaceutical Bulletin

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“…AR is characterized by a two-phase allergic reaction. In the early-phase inflammatory response, the allergen-IgE dependent activation of mast cells and basophils results in the production of pharmacologically active mediators such as histamine, prostaglandins, leukotrienes, and cytokines which produce sneezing, rhinorrhea, and itching (Jeong et al, 2009). The late-phase of AR shows accumulations of mast cells, eosinophils, and basophils in the epithelium and an accumulation of eosinophils in the deeper lamina propria (Fuentes-Beltrán et al, 2009).…”

Section: Discussionmentioning

confidence: 99%

Therapeutic effects of traditional Korean medicine, Jeechool-Whan in allergic rhinitis model

Oh¹,

Ryu²,

Cha³

et al. 2012

TANG [HUMANITAS MEDICINE]

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Jeechool-Whan (JW) is a prescription of Ponciri Fructus Immaturus and Atractylodis Rhizoma Alba and improves the functions of the stomach and the spleen. Although it is said in Korean Medicine that the spleen and the stomach are the roots of the body's resistance, the meaning of 'improving the spleen and the stomach' is very comprehensive. Moreover, there are lots of drugs that are said to improve the spleen and the stomach, and the number of prescriptions using these drugs is huge. In this study, we focused on the new effect and mechanism of the JW on the ovalbumin (OVA)-induced allergic rhinitis (AR) model. The increased number of rubs and the increased levels of IgE and histamine in the OVA-sensitized mice were inhibited by JW administration. The balance of Th1/Th2 cytokine level was regulated by JW administration. The levels inflammatory proteins were decreased by JW administration in the nasal mucosa of the OVA-sensitized mice. Eosinophils and mast cells infiltration increased by OVAsensitization was also decreased in the JW-administered mice. In addition, JW inhibited caspase-1 activity in the same nasal mucosa tissue. In activated human mast cells, JW inhibited the receptor interacting protein-2, IκB kinase-β, nuclear factor-κB/Rel A, and caspase-1 activation. In conclusion, this study will be support the clear understanding of the concept of the spleen and the stomach in traditional Korean medicine as well as for a possibility of finding a cure for this AR in traditional medical treatments.

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“…AR is characterized by a two-phase allergic reaction. In the early-phase inflammatory response, allergenIgE-dependent activation of mast cells and basophils results in the production of pharmacologically active mediators, such as histamine, prostaglandins, leukotrienes, and cytokines that produce sneezing, rhinorrhea, and itching (Jeong et al, 2009). The late-phase of AR shows accumulations of mast cells, eosinophils, and basophils in the epithelium and an accumulation of eosinophils in the deeper lamina propria (Fuentes-Beltrán et al, 2009).…”

Section: Discussionmentioning

confidence: 99%

Distinct Effects of Imperatorin on Allergic Rhinitis: Imperatorin Inhibits Caspase-1 Activity In Vivo and In Vitro

Oh¹,

Kim²,

Jeong³

2011

J Pharmacol Exp Ther

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Because imperatorin (IPT), the furanocoumarins exhibits antiinflammatory activity, we reasoned that IPT might modulate the allergic rhinitis (AR). The aim of this study was to analyze the regulation of AR by IPT. Here, we show the effect and mechanism of IPT in an ovalbumin (OVA)-induced AR model. The number of rubs after the OVA challenge in the OVA-sensitized mice was significantly higher than that in the OVA-unsensitized mice. The increased number of rubs was inhibited by the oral administration of IPT. The increased levels of IgE and histamine in the OVA-sensitized mice were reduced by IPT administration. The levels of interferon-␥ were enhanced, whereas the levels of interleukin (IL)-4 were reduced on the spleen tissue of the IPT-administered AR mice. Protein levels of IL-1␤, macrophage inflammatory protein-2, intercellular adhesion molecule-1, and cyclooxygenase-2 were reduced by IPT administration in the nasal mucosa of the OVA-sensitized mice. In the IPT-administered mice, the number of eosinophils and mast cells infiltration increased by OVA-sensitization were also decreased. In addition, IPT inhibited caspase-1 activity in the same nasal mucosa tissue. In activated human mast cells, the receptor-interacting protein 2 (RIP2), IB kinase (IKK)-␤, nuclear factor-B (NF-B)/ RelA, and caspase-1 activation were increased, but increased RIP2, IKK-␤, NF-B/RelA, and caspase-1 activation were inhibited by the treatment of IPT. In addition, IPT inhibited caspase-1 activity and IL-1␤ production in IgE-stimulated bone marrowderived mast cells. We can conclude that IPT exerts significant effects by regulating of caspase-1 activation in AR animal and in vitro models.

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Activation of hypoxia-inducible factor-1 regulates human histidine decarboxylase expression

Cited by 45 publications

References 32 publications

Roles of Histamine in Exercise-Induced Fatigue: Favouring Endurance and Protecting against Exhaustion

Roles of Histamine in Exercise-Induced Fatigue: Favouring Endurance and Protecting against Exhaustion

Therapeutic effects of traditional Korean medicine, Jeechool-Whan in allergic rhinitis model

Distinct Effects of Imperatorin on Allergic Rhinitis: Imperatorin Inhibits Caspase-1 Activity In Vivo and In Vitro

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