Activation of Leukopoiesis in Rat Blood with Trimecaine-Based Ionic Compounds

Baktybayeva, L. K.; Yu, V. К.; Zazybin, Alexey; Zolotareva, Darya; Dauletbakov, Anuar

doi:10.1155/2020/7636290

Cited by 5 publications

(3 citation statements)

References 5 publications

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“…At the same time, ionic compounds based on trimecaine have not been studied sufficiently, especially in terms of their pharmacological activity. The first reports on the leucopoiesis-stimulating and plant-growth-regulating activities of the ionic compounds based on trimecaine were published in [ 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 ].…”

Section: Introductionmentioning

confidence: 99%

Stimulation of B-Lymphopoiesis by Administration of a Trimecaine-Based Ionic Compound in Cyclophosphamide-Induced Hematopoietic-Depressive Model

et al. 2023

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According to the WHO, the secondary form of hematopoietic-depressive status increases the risk of death in people with oncological, infectious, and hormonal diseases. The choice of drugs that stimulate the hematopoietic activity of B-lymphopoiesis is limited. The current leucopoiesis drugs have a number of side effects: thymic preparations stimulate the production of PGE2, which causes chronic inflammation and various autoimmune diseases through the differentiation of T helper 1 (Th1) cells, the proliferation of Th17 cells, and the production of IL-22 from Th22 cells through EP2 and EP4 receptors; cytokine preparations can cause uncontrolled immune reactions and impaired contractility of smooth and cardiac muscles; drugs based on nucleic acids can stimulate the division of all cells, including bacterial and cancerous ones. The use of oligonucleotides such as ribozymes and antisense oligodeoxynucleotides (AS-ODNs) shows promise as therapeutic moieties, but faces a number of challenges such as nuclease sensitivity, off-target effects, and efficient delivery. The search for substances that stimulate B-lymphopoiesis among ionic compounds was motivated by the discovery of the unique properties of lidocaine docusate, one of the first ionic liquid forms of the known drugs. The lidocaine docusate (protonated form of lidocaine (2-(diethylamino)-N-(2,6-dimethylphenyl) acetamide + docusate-anion (dioctylsulfosuccinate))) suppresses the division of pheochromocytoma cells and activates immunity in rats. The trimecaine-based ionic compound (TIC) demonstrates high B-lymphopoiesis-stimulating activity. The TIC compound stimulates an increase in the volume of transitional B cells, which play an important role for further differentiation and formation of a sufficient number of mature B1 cells and mature B2 cells, where mature B2 cells make up the bulk of the functional population of B lymphocytes. The TIC compound most strongly stimulated the restoration of the number of marginal zone B cells, follicular B cells, and activated germinal center B cells after the cytotoxic emptying of the follicular centers of the spleen induced cyclophosphamide. It significantly exceeds the activity of the comparison drug methyluracil. The TIC compound does not affect the level of pro-B, pre-B-I, or pre-B-II bone marrow cells, which prevents the risk of the formation of immature functionally defective cells.

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Section: Introductionmentioning

confidence: 99%

Stimulation of B-Lymphopoiesis by Administration of a Trimecaine-Based Ionic Compound in Cyclophosphamide-Induced Hematopoietic-Depressive Model

et al. 2023

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“…Recently it was found that some of the compounds exhibiting mielostimulating activity [14,15] also show growth stimulating activity [16], moreover, most of these ionic compounds were found to be non-toxic towards A. Fischeri which make them promising sustainable and environmentally friendly growth stimulants. Herein we report about the synthesis and growth regulating activity of new ionic compound obtained via N-alkylation of trimecaine.…”

Section: Introductionmentioning

confidence: 99%

Conventional and Nonconventional Methods of Synthesis and Growth-Stimulating Activity of 3-Chloro-N,n-Diethyl-N-(2-(Mesitylamino)-2-Oxoethyl)propan-1-Aminium Iodide

Dauletbakov¹,

Belyankova²,

Tursynbek³

et al. 2021

Chem. J. of Kaz.

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Synthesis of 3-chloro-N,N-diethyl-N-(2-(mesitylamino)-2-oxoethyl)propan-1-aminium iodide (1) was performed by via N-alkylation in conventional conditions and using microwave irradiation and ultrasound activation. The synthesized ionic compound was characterized using IR, 1H and 13C NMR, growth-stimulating activity had been tested for ten varieties and hybrids of sweet sorghum seeds.

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“…[15][16][17] In the present study, new ionic compounds were prepared via N-alkylation of tolperisone, diphenhydramine and trimecaine with alkyl halides (Scheme 1, Table 1). Since some of the synthesized ionic compounds have been proven to stimulate plant growth, [18,19] the ecotoxicity and myelostimulating [20] data for these substances is of great importance.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Ecotoxicological Studies of Ionic Compounds Based on Tolperisone, Diphenhydramine and Trimecaine

et al. 2020

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Ionic compounds have been of global interest since stepping into a mature field of research. The aim of this study was to synthesize novel and known ionic compounds via the N‐alkylation process and fully characterize them by elemental analysis and infrared (IR) and nuclear magnetic resonance (NMR) spectroscopy. Investigation of the influence of the alkyl chain length and the charge of the cation on the ecotoxicity of 11 new and known ionic compounds based on tolperisone, diphenhydramine and trimecaine was investigated with the use of luminescence inhibition assay. To give information about the ecotoxicity of these new ionic compounds, the acute toxicity dataset of each compound was determined using Aliivibrio fischeri bacteria as a biomodel. According to the obtained results, the studied compounds could be considered non‐harmful to Aliivibrio fischeri. A quantitative structure–activity relationship (QSAR) study was carried out with the aim of modelling the observed behaviour and providing a prediction basis for ecotoxicity towards Aliivibrio fischeri.

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Activation of Leukopoiesis in Rat Blood with Trimecaine-Based Ionic Compounds

Cited by 5 publications

References 5 publications

Stimulation of B-Lymphopoiesis by Administration of a Trimecaine-Based Ionic Compound in Cyclophosphamide-Induced Hematopoietic-Depressive Model

Stimulation of B-Lymphopoiesis by Administration of a Trimecaine-Based Ionic Compound in Cyclophosphamide-Induced Hematopoietic-Depressive Model

Conventional and Nonconventional Methods of Synthesis and Growth-Stimulating Activity of 3-Chloro-N,n-Diethyl-N-(2-(Mesitylamino)-2-Oxoethyl)propan-1-Aminium Iodide

Synthesis and Ecotoxicological Studies of Ionic Compounds Based on Tolperisone, Diphenhydramine and Trimecaine

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