Activation of Nrf2 target enzymes conferring protection against oxidative stress in PC12 cells by ginger principal constituent 6-shogaol

Peng, Shoujiao; Yao, Juan; Liu, Yaping; Duan, Dongzhu; Zhang, Xiaolong; Fang, Jianguo

doi:10.1039/c5fo00214a

Cited by 77 publications

(52 citation statements)

References 59 publications

(119 reference statements)

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“…The compounds containing Michael acceptors are usually precluded in the process of traditional drug design due to Michael acceptors have the ability to react with various electron‐rich biomolecules. However, growing evidences have supported that drugs with Michael acceptors can become effective activators of Nrf2 signaling pathway , highlighting that Michael acceptor is a promising pharmacophore in parts of cytoprotective drugs. As shown in Fig.…”

Section: Discussionmentioning

confidence: 99%

Neuroprotection of mangiferin against oxidative damage via arousing Nrf2 signaling pathway in PC12 cells

et al. 2019

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Accumulating evidence demonstrates that oxidative stress is involved in the pathogenesis and progression of neurodegeneration. As NF-E2-related factor 2 (Nrf2) plays a crucial role in maintaining cellular redox homeostasis, small molecules with the ability in activation of Nrf2 pathway are promising neuroprotective agents. Mangiferin (Mg) is a xanthone glucoside extracted from mangoes and papayas, and has been reported to possess multiple pharmacological activities. In this study, we investigated neuroprotective effects of Mg in the neuron-like rat pheochromocytoma cell line (PC12 cells). Mg scavenges different kinds of free radicals in vitro and attenuates hydrogen peroxide-or 6-hydroxydopamine-induced cell death. After treatment with Mg, a range of antioxidant genes governed by Nrf2 were upregulated, and the expressions and activities of these gene products were also elevated. Moreover, knockdown of Nrf2 antagonized the protective effect of Mg, indicating that Nrf2 is an essential factor in this cytoprotective process. In summary, our study demonstrates that Mg is a potent antioxidant that can provide neuroprotection against oxidative stress-mediated damage of PC12 cells. © 2019 BioFactors, 45(3):381-392, 2019

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Section: Discussionmentioning

confidence: 99%

Neuroprotection of mangiferin against oxidative damage via arousing Nrf2 signaling pathway in PC12 cells

et al. 2019

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“…Study by Moon et al (2014) [20] revealed that administration of 6-shogaol significantly enhanced learning and memory in both memory-impaired and normal mice. A recent study by Peng et al (2015) [21] reported that 6-shogaol possessed anti-oxidant and cytoprotective effects against oxidative stress-induced cell damage in PC-12 cells. Peng et al (2015) [21] further suggested that 6-shogaol may be a potential candidate for the prevention of oxidative stress-mediated neurodegenerative disorders.…”

Section: Introductionmentioning

confidence: 99%

“…A recent study by Peng et al (2015) [21] reported that 6-shogaol possessed anti-oxidant and cytoprotective effects against oxidative stress-induced cell damage in PC-12 cells. Peng et al (2015) [21] further suggested that 6-shogaol may be a potential candidate for the prevention of oxidative stress-mediated neurodegenerative disorders. However, to date, there are limited reports on the neuritogenic activity of the chemical compounds isolated from common ginger, notably 6-shogaol.…”

Section: Introductionmentioning

confidence: 99%

6-shogaol, a neuroactive compound of ginger (jahe gajah) induced neuritogenic activity via NGF responsive pathways in PC-12 cells

Seow

Hong

Lee

et al. 2017

BMC Complement Altern Med

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Background: Ginger is a popular spice and food preservative. The rhizomes of the common ginger have been used as traditional medicine to treat various ailments. 6-Shogaol, a pungent compound isolated from the rhizomes of jahe gajah (Zingiber officinale var officinale) has shown numerous pharmacological activities, including neuroprotective and anti-neuroinflammatory activities. The aim of this study was to investigate the potential of 6-shogaol to mimic the neuritogenic activity of nerve growth factor (NGF) in rat pheochromocytoma (PC-12) cells.

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“…Furthermore, age-related impairments ultimately converge to negatively impact cell respiration, which manifests as the overproduction of reactive oxygen species (ROS). Oxidative stress is defined as an imbalance between the production of ROS or reactive nitrogen species (RNS) and the production of antioxidants (2). For this reason, oxidative stress has become the one of the main targets for the treatment of neurological diseases (3).…”

Section: Introductionmentioning

confidence: 99%

“…It has been reported to exert antioxidant protective effects against Pb-induced hepatotoxicity (11), and to exert significant beneficial effects on sperm viability, motility and serum total testosterone levels due to its antioxidant effects (12). [6]-Shogaol is a novel small molecule activator of nuclear factor (erythroid-derived 2)-like 2 (Nrf2) in PC12 cells, and therefore, it is a potential candidate for the prevention of oxidative stress-mediated neurodegenerative disorders (2). Furthermore, cysteine-conjugated shogaols in ginger have been found to induce apoptosis via an oxidative stress-mediated p53 pathway in human colon cancer cells (13).…”

Section: Introductionmentioning

confidence: 99%

Effects of ginger and its pungent constituents on transient receptor potential channels

Kim¹,

Hong²,

Lee³

et al. 2016

International Journal of Molecular Medicine

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Ginger extract is used as an analeptic in herbal medicine and has been reported to exert antioxidant effects. Transient receptor potential (TRP) canonical 5 (TRPC5), TRP cation channel, subfamily M, member 7 (TRPM7; melastatin 7), and TRP cation channel, subfamily A, member 1 (TRPA1; ankyrin 1) are non-selective cation channels that are modulated by reactive oxygen/nitrogen species (ROS/RNS) and subsequently control various cellular processes. The aim of this study was to evaluate whether ginger and its pungent constituents modulate these channels and exert antioxidant effects. It was found that TRPC5 and TRPA1 currents were modulated by ginger extract and by its pungent constituents, [6]-gingerol, zingerone and [6]-shogaol. In particular, [6]-shogaol markedly and dose-dependently inhibited TRPC5 currents with an IC50 of value of ~18.3 µM. Furthermore, the strong dose-dependent activation of TRPA1 currents by [6]-shogaol was abolished by A‑967079 (a selective TRPA1 inhibitor). However, ginger extract and its pungent constituents had no effect on TRPM7 currents. These results suggest the antioxidant effects of ginger extract and its pungent constituents are mediated through TRPC5 and TRPA1, and that [6]-shogaol is predominantly responsible for the regulation of TRPC5 and TRPA1 currents by ginger extract.

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Activation of Nrf2 target enzymes conferring protection against oxidative stress in PC12 cells by ginger principal constituent 6-shogaol

Cited by 77 publications

References 59 publications

Neuroprotection of mangiferin against oxidative damage via arousing Nrf2 signaling pathway in PC12 cells

Neuroprotection of mangiferin against oxidative damage via arousing Nrf2 signaling pathway in PC12 cells

6-shogaol, a neuroactive compound of ginger (jahe gajah) induced neuritogenic activity via NGF responsive pathways in PC-12 cells

Effects of ginger and its pungent constituents on transient receptor potential channels

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