Activation of platelet-rich plasma using thrombin receptor agonist peptide

Landesberg, Regina; Burke, Andrea; Pinsky, David J.; Katz, Ronald W.; Vo, Jennifer; Eisig, Sidney B.; Lu, Helen H.

doi:10.1016/j.joms.2004.12.007

Cited by 62 publications

(58 citation statements)

References 21 publications

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“…At a minimum, any procedure developed to concentrate platelets should be able to show a sufficiently high concentrate of platelets to affect a clinical outcome and demonstrate high percentage of growth factor in the resulting concentrate, as well as a variable platelet population [3,21]. So in our study PRP was prepared from 10cc of patient's blood and centrifuged twice in a clinical tabletop digital centrifuge as advocated by Aron Gonshor [21], Regina Landesberg et al [24], Rick C Tsay et al [25].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Efficacy of platelet rich plasma in bone regeneration after surgical removal of impacted bilateral mandibular third molars: pilot study

Gawande

Halli

2009

J. Maxillofac. Oral Surg.

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Section: Discussionmentioning

confidence: 99%

“…PRP can be activated with calcium chloride alone [15], calcium chloride along with bovine thrombin [4,25,26], human thrombin, autologous bone or autologous blood containing thrombin [21], TRAP (Thrombin Receptor Activator Peptide) [24,25] or ITA gelling agent [24].…”

Section: Discussionmentioning

confidence: 99%

Efficacy of platelet rich plasma in bone regeneration after surgical removal of impacted bilateral mandibular third molars: pilot study

Gawande

Halli

2009

J. Maxillofac. Oral Surg.

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“…Większość dostępnej literatury sugeruje konieczność aktywowania osocza bogatopłytkowego, głównie przez dodanie do uzyskanego PRP chlorku wapnia i/lub trombiny bydlęcej (rzadziej autogennej) (13). Innymi proponowanymi sposobami aktywacji trombocytów w PRP są: jego mrożenie (2) lub stosowanie syntetycznego peptydu podobnego do trombiny, nazywanego TRAP-6 (Thrombin Receptor Activator Peptide 6) (17,24).…”

Section: Osocze Bogatopłytkoweunclassified

“…Jej stosowanie w niektórych przypadkach powoduje powstanie przeciwciał przeciwko czynnikom krzepnięcia: V, XI i trombinie, co może prowadzić do rozwoju koagulopatii (4,11,17,24,27).…”

Section: Osocze Bogatopłytkoweunclassified

Autogenic platelet-rich plasma: Types, activation methods, and applications

Prządka¹,

Kiełbowicz²,

Skrzypczak³

2016

Medycyna Weterynaryjna

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SummaryPlatelet-rich plasma (PRP) is an autogenic source of many growth factors that are a part of the healing process and tissue regeneration, which is the cause of its growing popularity in regenerative medicine. In this paper, we present a definition and characteristics of PRP, as well as ways of extracting it. We also present the issue of thrombocyte activation and the impact of thrombocytes on PRP. We explain how to obtain the optimal density of platelets in PRP, as well as its influence on tissues. Additionally, we describe some of the applications of PRP in experimental and clinical work.

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“…It comprises of 0.2% by volume of whole blood, which converts to an insoluble fibrin meshwork in the presence of thrombin [2]. There has always been a demand by surgeons for natural substances that would assist in arrest of bleeding and perfect closure of wound margins.…”

Section: Introductionmentioning

confidence: 99%

Efficacy of Blood and Its Products-boon for Oral Surgeons: Review

Fareed¹,

Tandon²,

Z³

et al. 2017

J Univer Surg

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A set of scientific researches has focused its attention on discussing the possibility that platelet derivatives are not only coherent for haemostasis, but also have gained popularity in the field of tissue healing. Products obtained from whole blood as a result of centrifugation have wide applications in this field. Various materials are commercially available that are used locally to achieve haemostasis; however platelets and fibrinogen are the natural blood components that exists as a source in coagulation process. Platelets carry platelet-derived growth factors which, when introduced into an injured region, may stimulate a healing response through the recruitment of stem cells, increased vascularization and the production of collagen enhancing both soft and hard tissue healing. Injection of collected venous blood could be a scaffold for new bone formation which is helpful in restricting mouth opening in TMJ subluxation. Injections are inexpensive, simple to acquire, accord minimal trauma with minimal risk for allergic reactions. The purpose of this paper is to provide collective information regarding the various centrifuged products obtained from blood and their application in different ways.

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Activation of platelet-rich plasma using thrombin receptor agonist peptide

Cited by 62 publications

References 21 publications

Efficacy of platelet rich plasma in bone regeneration after surgical removal of impacted bilateral mandibular third molars: pilot study

Efficacy of platelet rich plasma in bone regeneration after surgical removal of impacted bilateral mandibular third molars: pilot study

Autogenic platelet-rich plasma: Types, activation methods, and applications

Efficacy of Blood and Its Products-boon for Oral Surgeons: Review

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